Zobrazeno 1 - 10
of 362
pro vyhledávání: '"NR4A"'
Autor:
Jian Liu, Min Wu, Yifan Yang, Xinyu Mei, Liming Wang, Jingyu Wang, Zixuan Wang, Shan He, Hangyu Liu, Han Jiang, Shen Qu, Yuwei Zhang, Ying Chen, Xun Tian, Yafei Huang, Hui Wang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Clinical trials have shown that immunotherapy based on Vγ9Vδ2 T cells (Vδ2 T cells) is safe and well-tolerated for various cancers including cervical cancer (CC), but its overall treatment efficacy remains limited. Therefore, e
Externí odkaz:
https://doaj.org/article/55b102c0746543a88b6f2bc28deb4dd8
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract Background Investigating the underlying molecular mechanisms responsible for endometrial dysfunction in women with PCOS is essential, particularly focusing on the role of hyperinsulinemia. Methods We explored the role of insulin in the decid
Externí odkaz:
https://doaj.org/article/b5c9175309c64611b0e1ce8ba49a15fb
Autor:
Maryam Mohammadi, Hossein Asgarian-Omran, Behnam Najafi, Ahmad Najafi, Reza Valadan, Hossein Karami, Mohammad Naderisoraki, Maryam Alizadeforutan, Ramin Shekarriz, Mohsen Tehrani
Publikováno v:
Iranian Journal of Immunology, Vol 20, Iss 4, Pp 438-445 (2023)
Background: Thymocyte selection-associated high mobility group box protein (TOX) and members of the nuclear receptor 4A (NR4A) are known as transcription factors involved in T cell exhaustion.Objective: To evaluate the mRNA expression of TOX and NR4A
Externí odkaz:
https://doaj.org/article/9e1db0fc3a11477aa3f681d560a42aa6
Autor:
Francesca Montarolo, Serena Martire, Fabiana Marnetto, Paola Valentino, Sabdi Valverde, Marco Alfonso Capobianco, Antonio Bertolotto
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 3, Pp 1247-1256 (2022)
Fingolimod (FTY720) and siponimod (BAF312) are selective agonists for sphingosine-1-phosphate (S1P) receptors approved for the treatment of relapsing–remitting (RR) and secondary progressive (SP) multiple sclerosis (MS), respectively. BAF312 exerts
Externí odkaz:
https://doaj.org/article/29b5a292c9e84dbc8f52e6e530a4106f
Akademický článek
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Akademický článek
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Autor:
Mansour Haddad
Publikováno v:
Pathophysiology, Vol 28, Iss 4, Pp 457-470 (2021)
Cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two G-protein-coupled cannabinoid receptors, CB1 and CB2. One suggested theory is that cannabinoids regulate a variety of physiologi
Externí odkaz:
https://doaj.org/article/906b4717289d4b81848952897ce780de
Akademický článek
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Autor:
Evelyn P. Murphy, Daniel Crean
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The development and progression of immune-mediated rheumatic disease (IMRD) involves dysfunction of innate and adaptive immune cell populations leading to altered responses including inflammasome activation, dysregulated cytokine networks, increased
Externí odkaz:
https://doaj.org/article/600746eb950a44258c528b2e49acdf42
Autor:
Takashi Sekiya
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Although the “lymphoid” function of regulatory T (Treg) cells is crucial for organismal homeostasis, these cells are also known to suppress the antitumor immune response in the tumor microenvironments. Thus, a detailed understanding of Treg cell
Externí odkaz:
https://doaj.org/article/449bd3bb1b824481835c221b5090162c