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NR3C1 and NR3C2 Genes Increase the Risk of Suicide Attempt in Psychiatric Disorder Patients with History of Childhood Trauma

Autor: Sanabrais-Jiménez MA, Esquivel-López AA, Sotelo-Ramírez CE, Aguilar-García A, Ordoñez-Martínez B, Jiménez-Pavón J, Madrigal-Lara MV, Díaz-Vivanco AJ, Camarena B

Publikováno v: Neuropsychiatric Disease and Treatment, Vol Volume 19, Pp 2561-2571 (2023)

Marco Antonio Sanabrais-Jiménez,1 Ayerim Alma Esquivel-López,2 Carlo Esteban Sotelo-Ramírez,1 Alejandro Aguilar-García,1 Bruno Ordoñez-Martínez,1 Joanna Jiménez-Pavón,3 María Victoria Madrigal-Lara,3 Alan Jair Díaz-Vivanco,3 Beatriz Camaren

Externí odkaz: https://doaj.org/article/b14dc35d73574b7ebce3a60cc8fcba14

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Akademický článek

Autor: Alejandro Lomniczi, Selva L. Luna, Rita Cervera-Juanes, Maria-Luisa Appleman, Steven G. Kohama, Henryk F. Urbanski

Publikováno v: Frontiers in Aging Neuroscience, Vol 16 (2024)

IntroductionThe hippocampus is especially susceptible to age-associated neuronal pathologies, and there is concern that the age-associated rise in cortisol secretion from the adrenal gland may contribute to their etiology. Furthermore, because 11β-h

Externí odkaz: https://doaj.org/article/32e8e7987f654b6eab34aa0fcfdb61e8

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Akademický článek

NR3C2 mediates oxidised low-density lipoprotein-induced human coronary endothelial cells dysfunction via modulation of NLRP3 inflammasome activation

Autor: Xiaofan Chen, Weidong Li, Chengdong Chang

Publikováno v: Autoimmunity, Vol 56, Iss 1 (2023)

Nuclear receptor subfamily 3 group C member 2 (NR3C2) has been revealed to affect the progression of multiple inflammatory diseases, while NR3C2’s efficacy in coronary artery disease (CAD) remains largely unsolved. The study intended to elucidate t

Externí odkaz: https://doaj.org/article/ae66ce596a5643a886ce10ef6018460b

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Akademický článek

Effects of environmental and genetic interactions on job burnout in coal miners: interactions between occupational stress, coping styles, and NR3C2 gene polymorphisms

Autor: Xin Lin, Xiaofan Ma, Xiaoting Yi, Chao Qu, Fuye Li

Publikováno v: Frontiers in Public Health, Vol 11 (2023)

ObjectivesTo investigate the current situation regarding occupational burnout among coal miners, explore the relationship between NR3C2 gene polymorphism and occupational burnout, and analyze the influence of the interaction between environment and g

Externí odkaz: https://doaj.org/article/c0c5a14a31854944aeeb1a9191ef94aa

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Akademický článek

The expression of glucocorticoid and mineralocorticoid receptors in pituitary tumors causing Cushing’s disease and silent corticotroph tumors

Autor: Paulina Kober, Natalia Rusetska, Beata J. Mossakowska, Maria Maksymowicz, Monika Pękul, Grzegorz Zieliński, Andrzej Styk, Jacek Kunicki, Łukasz Działach, Przemysław Witek, Mateusz Bujko

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

ObjectivePituitary neuroendocrine corticotroph tumors commonly cause Cushing’s disease (CD) that results from increased adrenocorticotropic hormone (ACTH) secretion by the pituitary tumor and consequent increase of cortisol levels in blood. However

Externí odkaz: https://doaj.org/article/1a1d87f12f4d44ccbbb3de019e753037

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Akademický článek

Novel linkage and association of the mineralocorticoid receptor gene (NR3C2) with familial type 2 diabetes and depression and their comorbidity

Autor: Mutaz Amin, Shumail Syed, Rongling Wu, Teodor T. Postolache, Claudia Gragnoli

Publikováno v: Aspects of Molecular Medicine, Vol 1, Iss , Pp 100003- (2023)

Introduction: The mineralocorticoid receptor gene (NR3C2) appears to modulate stress and cognitive performance in patients with major depressive disorder (MDD). In addition, abnormalities in NR3C2 are associated in rodents with type 2 diabetes (T2D)

Externí odkaz: https://doaj.org/article/0e2ac63cf94e4f7e939236eac2f78d39

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Akademický článek

CREB1-induced miR-1204 promoted malignant phenotype of glioblastoma through targeting NR3C2

Autor: Xinli Zhao, Fazheng Shen, Jiwei Ma, Shupeng Zhao, Lei Meng, Xiangyang Wang, Shufeng Liang, Jianing Liang, Chaoshuai Hu, Xinzhong Zhang

Publikováno v: Cancer Cell International, Vol 20, Iss 1, Pp 1-10 (2020)

Abstract Background Glioblastoma (GBM) is a subclass of brain malignancy with unsatisfactory prognosis. MicroRNAs (miRNAs) are a group of non-coding RNAs (ncRNAs) that exert key function on tumorigenesis and tumor development. Purposes The purpose of

Externí odkaz: https://doaj.org/article/16243ba0298e45bea6e52b65afe10dbe

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Network Pharmacology–Based Identification of Key Mechanisms of Xihuang Pill in the Treatment of Triple-Negative Breast Cancer Stem Cells

Autor: Yu-Zhu Zhang, Jia-Yao Yang, Rui-Xian Wu, Chen Fang, Hai Lu, Hua-Chao Li, Dong-Mei Li, Hua-Li Zuo, Li-Ping Ren, Xiao-Yuan Liu, Rui Xu, Jia-Huai Wen, Hsien-Da Huang, Ri Hong, Qian-Jun Chen

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Xihuang pill, an approved Chinese medicine formula (state medical permit number. Z11020073), is a commonly used adjuvant drug for cancer patients in China. Xihuang pill has a satisfactory effect in treating breast cancer in clinics, especially triple

Externí odkaz: https://doaj.org/article/a35474bf6ee54fdbb52e02c246097f74

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