Výsledky vyhledávání - "NQO1, NAD(P)H: quinone oxidoreductase 1"

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

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Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Autor: Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303

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HEATR1 deficiency promotes pancreatic cancer proliferation and gemcitabine resistance by up-regulating Nrf2 signaling

Autor: Keke Wang, Yaxin Chen, Yang Zhou, Rui Wang, Tao Li, Rong Hu, Mengran Cao, Mengdi Yang, Yunjiang Zhou

Publikováno v: Redox Biology, Vol 29, Iss, Pp-(2020)
Redox Biology

The human HEAT repeat-containing protein 1 (HEATR1), consisting of 2144 amino acids, is a member of the UTP10 family and contains one HEAT repeat at its C-terminal. HEATR1 has been reported to regulate cytotoxic T lymphocytes and rRNA synthesis, whil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e05750c9088c8fa20275c4fdf10c40
http://www.sciencedirect.com/science/article/pii/S2213231719309498

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A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity

Autor: Mengjie Xiao, Yufeng Tang, Jie Wang, (a), Guangping Lu, Jianlou Niu, Jie Wang, (b), Jiahao Li, Qingbo Liu, Zhaoyun Wang, Zhifeng Huang, Yuanfang Guo, Ting Gao, Xiaohui Zhang, Shouwei Yue, Junlian Gu

Publikováno v: Redox Biology
Redox Biology, Vol 49, Iss, Pp 102219-(2022)

A cumulative and progressively developing cardiomyopathy induced by adriamycin (ADR)-based chemotherapy is a major obstacle for its clinical application. However, there is a lack of safe and effective method to protect against ADR-induced cardiotoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117dd84ba405e2dbdd1e828959acff0c
https://doi.org/10.1016/j.redox.2021.102219

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Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

Autor: Rui-Qing Jiao, Xiao-Juan Zhao, Lin-Lin Kang, Han-Wen Yu, Ling-Dong Kong, Yan-Zi Yang, Wen-Yuan Wu, Ke-Ke Jia, Tian-Yu Chen

Publikováno v: Redox Biology, Vol 18, Iss, Pp 124-137 (2018)
Redox Biology

Oxidative stress is a critical factor in nonalcoholic fatty liver disease pathogenesis. MicroRNA-200a (miR-200a) is reported to target Kelch-like ECH-associated protein 1 (Keap1), which regulates nuclear factor erythroid 2-related factor 2 (Nrf2) ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483b832538db0d06f516c7947b302ae8
https://doi.org/10.1016/j.redox.2018.07.002

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Redox control of cancer cell destruction

Autor: Hegedűs, Csaba, Kovács, Katalin, Polgár, Zsuzsanna, Regdon, Zsolt, Szabó, Éva, Robaszkiewicz, Agnieszka, Forman, Henry Jay, Martner, Anna, Virág, László

Publikováno v: Redox Biology, Vol 16, Iss, Pp 59-74 (2018)
Redox Biology

Redox regulation has been proposed to control various aspects of carcinogenesis, cancer cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As cancer has many faces, the role of redox control in different cancers and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::153be7bc8a9501b142b779dbaf4a96d6
http://www.sciencedirect.com/science/article/pii/S2213231717309424

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Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Autor: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)

Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the acetylenic tricyclic bis(cyano enone) TBE-31 would suppress NASH becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012
https://doi.org/10.1016/j.jcmgh.2017.11.016

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Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats

Autor: Stiborová, Marie, Dračínská, Helena, Bořek-Dohalská, Lucie, Klusoňová, Zuzana, Holecová, Jana, Martínková, Markéta, Schmeiser, Heinz H., Arlt, Volker M.

Publikováno v: Toxicology

Graphical abstract Effects of 17α-ethinylestradiol (EE2) and estradiol (ESTRA) on DNA adducts formed by benzo[a]pyrene (BaP).
Highlights • 17α-ethinylestradiol (EE2) and estradiol affect genotoxicity of benzo[a]pyrene (BaP) in rats. • Cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1f71ff44ca27ad36f725ddc115059dc
http://europepmc.org/articles/PMC6593260

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Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

Autor: Antonio Cuadrado, Marta Pajares, Ana I. Rojo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Redox Biology, Vol 11, Iss, Pp 543-553 (2017)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology

Neurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of proteostasis. Proteostasis refers to all the processes by which cells control the abundance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f92176ef6df1b38f56b20a10b5b1ad8

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(-)-Epicatechin attenuates hepatic sinusoidal obstruction syndrome by inhibiting liver oxidative and inflammatory injury

Autor: Zhengtao Wang, Yuchen Sheng, Zhanxia Hao, Lili Ji, Xiaoqi Jing, Zhenlin Huang, Jiaqi Zhang

Publikováno v: Redox Biology
Redox Biology, Vol 22, Iss, Pp-(2019)

Hepatic sinusoidal obstruction syndrome (HSOS) is a rare liver disease with considerable morbidity and mortality. (-)-Epicatechin (EPI) is a natural flavonol. This study aims to investigate the protection of EPI against monocrotaline (MCT)-induced HS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10399ed0ce5ab7a59c41310ef32ed9c1
http://europepmc.org/articles/PMC6395886

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