Adiponectin, leptin, cortisol, neuropeptide Y and profile of mood states in athletes participating in an ultramarathon during winter: An observational study

Autor: Camilla Kienast, Katharina Biere, Robert H. Coker, Nikolai N. Genov, Marc Jörres, Martina Anna Maggioni, Lea Mascarell-Maricic, Adriane Schalt, Magdalena Genov, Hanns-Christian Gunga, Mathias Steinach

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Background: The Montane® Yukon Arctic Ultra (YAU) is one of the longest (690 km) and coldest (+10.6°C–43.9°C) ultramarathons worldwide. Taking part in an ultramarathon is associated with great physiological and psychological stress, which can af

Externí odkaz: https://doaj.org/article/8a4fd794c9eb4ed6bd353fbc34cc05b8

NPY1R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression

Autor: Nora Klöting, Stefanie Wittrisch, Annette G. Beck-Sickinger, Matthias Blüher, Karin Mörl, Rima Chakaroun

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 31, Iss, Pp 163-180 (2020)
Mol. Metab. 31, 163-180 (2020)

Objective PPARα/γ dual agonists have been in clinical development for the treatment of metabolic diseases including type 2 diabetes and dyslipidemia. However, severe adverse side effects led to complications in clinical trials. As most of the benef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8a5984d3babe4cd79f900f950e2c37
https://doi.org/10.1016/j.molmet.2019.11.009

Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

Autor: Fanny Langlet, Bernard Thorens, Antoine Rohrbach, Irina Kolotuev, Emilie Caron, Roxane Pasquettaz, Federico Santoni, Rafik Dali, Maxime Brunner

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101311-(2021)

Objectives Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of GCK-expressing tanycytes in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c27ff32b82421b71e5764fb0b90600
https://pubmed.ncbi.nlm.nih.gov/34325016

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice

Autor: Estefanía P. Bello, Ramiro Alsina, Viviana Florencia Bumaschny, María B. Tavella, Milagros Trotta, José Luis Ferran, Marcelo Rubinstein

Publikováno v: Molecular Metabolism, Vol 37, Iss, Pp 100985-(2020)
Molecular Metabolism
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Objective Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis, and stress-induced analgesia. Since these neurons heterogeneously e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed00f6a11823c774341490a25507dc2
http://www.sciencedirect.com/science/article/pii/S2212877820300594

A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord

Autor: Boyle, Kieran A., Gutierrez-Mecinas, Maria, Polgár, Erika, Mooney, Nicole, O'Connor, Emily, Furuta, Takahiro, Watanabe, Masahiko, Todd, Andrew J.

Publikováno v: Neuroscience

Highlights • Neurochemistry of lamina I–II inhibitory neurons in mouse is similar to that in rat. • Five neurochemical classes account for all lamina I–II inhibitory neurons in mouse. • Excitatory dynorphin cells are largely restricted to g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f0b1b7c121133e0f8096dafa483657a
http://europepmc.org/articles/PMC5648048