Zobrazeno 1 - 10
of 115
pro vyhledávání: '"NORMAN P. CURTHOYS"'
Publikováno v:
Neurochemistry International. 88:10-14
The GLS1 gene encodes a mitochondrial glutaminase that is highly expressed in brain, kidney, small intestine and many transformed cells. Recent studies have identified multiple lysine residues in glutaminase that are sites of N-acetylation. Interesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f6fb8fa4a3e9e42501f9774b3fc486
https://doi.org/10.1016/j.neuint.2014.12.003
https://doi.org/10.1016/j.neuint.2014.12.003
Autor:
Norman P. Curthoys
Publikováno v:
Glutamine ISBN: 9781315373164
Glutamine is the most abundant free amino acid in the human body. With an arterial plasma concentration of 0.5–0.8 mM, the circulating pool of glutamine constitutes 20%–25% of the plasma amino acids. This chapter provides a brief overview of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f141c559060d500161d8cc281e3a56
https://doi.org/10.1201/9781315373164-3
https://doi.org/10.1201/9781315373164-3
Publikováno v:
American Journal of Physiology-Renal Physiology. 307:F1-F11
Ammoniagenesis and gluconeogenesis are prominent metabolic features of the renal proximal convoluted tubule that contribute to maintenance of systemic acid-base homeostasis. Molecular analysis of the mechanisms that mediate the coordinate regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2331620d3ba2ac94ca20155cf753d178
https://doi.org/10.1152/ajprenal.00067.2014
https://doi.org/10.1152/ajprenal.00067.2014
Publikováno v:
American Journal of Physiology-Renal Physiology. 304:F145-F155
Metabolic acidosis is a common clinical condition that is caused by a decrease in blood pH and bicarbonate concentration. Increased extraction and mitochondrial catabolism of plasma glutamine within the renal proximal convoluted tubule generates ammo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dc149ef6ebf549f7ed5f34529173d0
https://doi.org/10.1152/ajprenal.00526.2012
https://doi.org/10.1152/ajprenal.00526.2012
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F1465-F1477
The physiological response to the onset of metabolic acidosis requires pronounced changes in renal gene expression. Adaptations within the proximal convoluted tubule support the increased extraction of plasma glutamine and the increased synthesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa22af3ea23ca10ebf392153e963304
https://doi.org/10.1152/ajprenal.00390.2011
https://doi.org/10.1152/ajprenal.00390.2011
Autor:
Jianqing Ding, Changhai Tian, Kangmu Ma, Beibei Jia, Norman P. Curthoys, Jialin C. Zheng, Lijun Sun
Publikováno v:
Journal of Neuroimmune Pharmacology. 7:619-628
Human immunodeficiency virus (HIV) induces a neurological disease culminating in frank dementia referred to as HIV-associated dementia (HAD). Neurotoxins from HIV-1-infected and activated mononuclear phagocytes contribute to the neuropathogenesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c267b53de7b5c946bfe2f5fe2117475
https://doi.org/10.1007/s11481-012-9364-1
https://doi.org/10.1007/s11481-012-9364-1
Autor:
Judy Mufti, Sachin Hajarnis, Lynn Taylor, Kelly Shepardson, Norman P. Curthoys, Lakshmi Gummadi
Publikováno v:
American Journal of Physiology-Renal Physiology. 301:F1066-F1077
Onset of metabolic acidosis leads to a rapid and pronounced increase in expression of phosphoenolpyruvate carboxykinase (PEPCK) in rat renal proximal convoluted tubules. This adaptive response is modeled by treating a clonal line of porcine LLC-PK1-F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b589fc76400de62f2c532776f15abaa
https://doi.org/10.1152/ajprenal.00303.2011
https://doi.org/10.1152/ajprenal.00303.2011
Publikováno v:
American Journal of Physiology-Renal Physiology. 298:F1323-F1331
The renal proximal convoluted tubule is the primary site of water, electrolyte and nutrient reabsorption and of active secretion of selected molecules. Proteins in the apical brush-border membrane facilitate these functions and initiate some of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206415e570dccf4ddda6349126a2f342
https://doi.org/10.1152/ajprenal.00711.2009
https://doi.org/10.1152/ajprenal.00711.2009
Autor:
Changhai Tian, Jianxing Zhao, Yunlong Huang, Nathan Erdmann, Norman P. Curthoys, Jialin C. Zheng, Shelley Herek
Publikováno v:
Journal of Neurochemistry. 109:551-561
Mononuclear phagocyte (MP, macrophages and microglia) dysfunction plays a significant role in the pathogenesis of HIV-1-associated dementia (HAD) through the production and release of soluble neurotoxic factors including glutamate. Glutamate producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5a440bc9d64328bf9fbed466aece0e
https://doi.org/10.1111/j.1471-4159.2009.05989.x
https://doi.org/10.1111/j.1471-4159.2009.05989.x
Publikováno v:
Kidney International. 73(1):11-18
The renal response to metabolic acidosis is mediated, in part, by increased expression of the genes encoding key enzymes of glutamine catabolism and various ion transporters that contribute to the increased synthesis and excretion of ammonium ions an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ec977c70141f0bf2bf238d0706ad9c