Zobrazeno 1 - 10
of 92
pro vyhledávání: '"NORIKO TOYAMA-SORIMACHI"'
Autor:
Tsubasa Tanaka, Tamaki Yano, Shingo Usuki, Yoko Seo, Kento Mizuta, Maho Okaguchi, Maki Yamaguchi, Kazuko Hanyu-Nakamura, Noriko Toyama-Sorimachi, Katja Brückner, Akira Nakamura
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract RNA interference (RNAi) is a gene-silencing mechanism triggered by the cytosolic entry of double-stranded RNAs (dsRNAs). Many animal cells internalize extracellular dsRNAs via endocytosis for RNAi induction. However, it is not clear how the
Externí odkaz:
https://doaj.org/article/07329bdfa98a45bfa711d24abbdee6c2
Autor:
Motoyoshi Nagai, Takuma Okawa, Kazuaki Nakata, Daisuke Takahashi, Reina Miyajima, Hiroaki Shiratori, Daisuke Yamanaka, Atsuo Nakamura, Chinatsu Oyama, Shin-Ichiro Takahashi, Noriko Toyama-Sorimachi, Koichiro Suzuki, Wakana Ohashi, Taeko Dohi, Yuki I. Kawamura, Koji Hase
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114490- (2024)
Summary: Although oral tolerance is a critical system in regulating allergic disorders, the mechanisms by which dietary factors regulate the induction and maintenance of oral tolerance remain unclear. To address this, we explored the differentiation
Externí odkaz:
https://doaj.org/article/55b12c9964a04ec7ade407251c127f30
Autor:
Hitomi Karyu, Takahiro Niki, Yuriko Sorimachi, Shoji Hata, Shiho Shimabukuro-Demoto, Tetsuya Hirabayashi, Kojiro Mukai, Kohji Kasahara, Keiyo Takubo, Nobuhito Goda, Koichi Honke, Tomohiko Taguchi, Hiroyuki Sorimachi, Noriko Toyama-Sorimachi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Inhibitory natural killer (NK) cell receptors recognize MHC class I (MHC-I) in trans on target cells and suppress cytotoxicity. Some NK cell receptors recognize MHC-I in cis, but the role of this interaction is uncertain. Ly49Q, an atypical Ly49 rece
Externí odkaz:
https://doaj.org/article/70ff05ea7c2b4300b918de175f128002
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Amino acid transporters are generally recognized as machinery that transport amino acids from the extracellular environment into the cytoplasm. Although their primary function is the uptake of amino acids to supply the cell with nutrients and energy,
Externí odkaz:
https://doaj.org/article/2af25208b06741bbbaa9c691377f8ef3
Autor:
Dat Nguyen-Tien, Takehiro Suzuki, Toshihiko Kobayashi, Noriko Toyama-Sorimachi, Naoshi Dohmae
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101263- (2022)
Summary: The purpose of this protocol is to screen and identify the physiologically relevant interactors of a lysosomal protein in living cells. Here, we describe how to identify solute carrier family 15 member 4 (SLC15A4)-interacting proteins by Bio
Externí odkaz:
https://doaj.org/article/6a3f67a7896f48efa024528684f2c7dc
Publikováno v:
PLoS Biology, Vol 17, Iss 11, p e3000530 (2019)
Type I interferon (IFN-I) is a family of multifunctional cytokines that modulate the innate and adaptive immunity and are used to treat mastocytosis. Although IFN-I is known to suppress mast cell function, including histamine release, the mechanisms
Externí odkaz:
https://doaj.org/article/704fe1740be747ce83c42967ca3121d0
Publikováno v:
Bio-Protocol, Vol 5, Iss 16 (2015)
The endosome/lysosome systems play important roles in immune cell functions as signaling platforms. Immune cells utilize these endosome/lysosome for signal transduction or intercellular communication to elicit the proper immune responses, regulating
Externí odkaz:
https://doaj.org/article/16b2112e587f446eb2e2491c60f3a603
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0123223 (2015)
Macrophages play critical roles in the onset of various diseases and in maintaining homeostasis. There are several functional subsets, of which M1 and M2 macrophages are of particular interest because they are differentially involved in inflammation
Externí odkaz:
https://doaj.org/article/81b185c9760d46f3945c10533dc64a83
Autor:
Hirotake Imanishi, Gaku Takibuchi, Toshihiko Kobayashi, Kaori Ishikawa, Kazuto Nakada, Masayuki Mori, Yoshiaki Kikkawa, Keizo Takenaga, Noriko Toyama-Sorimachi, Jun-Ichi Hayashi
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75981 (2013)
In mammalian species, mitochondrial DNA (mtDNA) with pathogenic mutations that induce mitochondrial respiration defects has been proposed to be involved in tumor phenotypes via induction of enhanced glycolysis under normoxic conditions (the Warburg e
Externí odkaz:
https://doaj.org/article/3f956d1b06b14a1ea8aabea631650e76
Autor:
Shoji Hata, Manabu Abe, Hidenori Suzuki, Fujiko Kitamura, Noriko Toyama-Sorimachi, Keiko Abe, Kenji Sakimura, Hiroyuki Sorimachi
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001040 (2010)
Calpains constitute a superfamily of Ca2+-dependent cysteine proteases, indispensable for various cellular processes. Among the 15 mammalian calpains, calpain 8/nCL-2 and calpain 9/nCL-4 are predominantly expressed in the gastrointestinal tract and a
Externí odkaz:
https://doaj.org/article/fcc147a94f8b4dc5bc62ab06d08b9fb7