Zobrazeno 1 - 10
of 5 181
pro vyhledávání: '"NONMEM"'
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Objective This study aimed to develop a population pharmacokinetic (PPK) model for oral apatinib in Chinese oncology patients and investigate the factors influencing the pharmacokinetics of apatinib. Methods We gathered 199 blood concentrati
Externí odkaz:
https://doaj.org/article/1e9096f01ffd4f5b9f7365060cb85dfe
Autor:
Rančić Aleksandar, Milosavljević Miloš N., Rosić Nikola, Milovanović Dragan, Folić Marko, Zečević Dejana Ružić, Petrović Nemanja, Čorbić Mirjana Milojević, Dabanović Vera, Janković Slobodan M.
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 803-38 (2024)
The pharmacokinetics of meropenem are significantly altered in critically ill patients. A population pharmacokinetic study was designed to estimate typical values of meropenem clearance in critically ill patients and evaluate potential factors of inf
Externí odkaz:
https://doaj.org/article/f65fa220b750478396a1ca7e70102a14
Autor:
Paul Thoueille, Susana Alves Saldanha, Fabian Schaller, Eva Choong, François Veuve, Aline Munting, Matthias Cavassini, Dominique Braun, Huldrych F. Günthard, Jessy J. Duran Ramirez, Bernard Surial, Hansjakob Furrer, Andri Rauch, Pilar Ustero, Alexandra Calmy, Marcel Stöckle, Caroline Di Benedetto, Enos Bernasconi, Patrick Schmid, Catia Marzolini, François R. Girardin, Thierry Buclin, Laurent A. Decosterd, Monia Guidi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe pharmacokinetics of long-acting rilpivirine has mostly been studied in clinical trials, which do not fully address the uncertainties that arise in routine clinical situations.Aims and methodsOur population analysis aims to establish per
Externí odkaz:
https://doaj.org/article/58665483a2d948d0a939985937ee8dc8
Autor:
Yunfang Zhu, Yuxiang Xu, Haopeng Zhao, Hongxin Qie, Xiaonan Gao, Jinglin Gao, Zhangying Feng, Jing Bai, Rui Feng, Mingxia Wang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectivePyrotinb has been approved for the treatment of HER2-positive advanced or metastatic breast cancer in China. However, the plasma concentration of pyrotinb in different patients varies greatly, and in the course of treatment, if patients have
Externí odkaz:
https://doaj.org/article/e19b22ae1ccb4d77b2e13a7ede6a1d92
Autor:
Hinke Siebinga, Berlinda J. de Wit-van der Veen, Daphne M. V. de Vries-Huizing, Wouter V. Vogel, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema
Publikováno v:
EJNMMI Physics, Vol 11, Iss 1, Pp 1-24 (2024)
Abstract Background There is an unmet need for prediction of treatment outcome or patient selection for [177Lu]Lu-PSMA therapy in patients with metastatic castration-resistant prostate cancer (mCRPC). Quantification of the tumor exposure–response r
Externí odkaz:
https://doaj.org/article/8fff240eb4dd480799fca12f85a0fb21
Autor:
Yan Qin, Zheng Jiao, Yan-Rong Ye, Yun Shen, Zhe Chen, Yue-Ting Chen, Xiao-Yu Li, Qian-Zhou Lv
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 35, Iss , Pp 347-353 (2023)
ABSTRACT: Objectives: Several linezolid population pharmacokinetic (popPK) models have been established to facilitate optimal therapy; however, their extrapolated predictive performance to other clinical sites is unknown. This study aimed to external
Externí odkaz:
https://doaj.org/article/3965290b6f8742be9de4f1436b1279d0
Publikováno v:
Acta Pharmaceutica, Vol 73, Iss 2, Pp 175-194 (2023)
The aim of this study was to externally validate the predictive performance of published population pharmacokinetic models of gentamicin in all paediatric age groups, from preterm newborns to adolescents. We first selected published population pharma
Externí odkaz:
https://doaj.org/article/3f9d5a681bcf41a6804ae05f278348d0
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: While vancomycin remains a widely prescribed antibiotic, it can cause ototoxicity and nephrotoxicity, both of which are concentration-associated. Overtreatment can occur when the treatment lasts for an unnecessarily long time. Using a m
Externí odkaz:
https://doaj.org/article/73e1640888414b74a594e7348cb6de80
Autor:
Anning Li, Wen Yao Mak, Tingyi Ruan, Fang Dong, Nan Zheng, Meng Gu, Wei Guo, Jingye Zhang, Haoxuan Cheng, Canjun Ruan, Yufei Shi, Yannan Zang, Xuequan Zhu, Qingfeng He, Xiaoqiang Xiang, Gang Wang, Xiao Zhu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Amisulpride is primarily eliminated via the kidneys. Given the clear influence of renal clearance on plasma concentration, we aimed to explicitly examine the impact of renal function on amisulpride pharmacokinetics (PK) via population P
Externí odkaz:
https://doaj.org/article/7c87345881964870a4c779fa7ade6f3b
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