Zobrazeno 1 - 10
of 709
pro vyhledávání: '"NOG"'
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-9 (2024)
Abstract The transplantation of human mesenchymal stromal/stem cells (hMSCs) has potential as a curative and permanent therapy for congenital skeletal diseases. However, the self-renewal and differentiation capacities of hMSCs markedly vary. Therefor
Externí odkaz:
https://doaj.org/article/5e17228cd72f4829bb49f02c57a4b432
Autor:
Tingting Wang, Lijuan Ding, Huiying Luo, Huoqing Huang, Xiaoyun Su, Yingguo Bai, Tao Tu, Yuan Wang, Xing Qin, Honglian Zhang, Yaru Wang, Bin Yao, Jie Zhang, Xiaolu Wang
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Methyl methacrylate (MMA) is a key precursor of polymethyl methacrylate, extensively used as a transparent thermoplastic in various industries. Conventional MMA production poses health and environmental risks; hence, citramalate s
Externí odkaz:
https://doaj.org/article/533756918662444d9aa132df2df11510
Autor:
Ryoji Ito, Yusuke Ohno, Yunmei Mu, Yuyo Ka, Shuko Ito, Maiko Emi-Sugie, Misa Mochizuki, Kenji Kawai, Motohito Goto, Tomoyuki Ogura, Riichi Takahashi, Akira Niwa, Tatsutoshi Nakahata, Mamoru Ito
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human C
Externí odkaz:
https://doaj.org/article/5fb3c7fe2ac54a79a530db9b5302a07c
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background trans-4-Hydroxyproline (T-4-HYP) is a promising intermediate in the synthesis of antibiotic drugs. However, its industrial production remains challenging due to the low production efficiency of T-4-HYP. This study focused on desig
Externí odkaz:
https://doaj.org/article/5e26f1578fe94cb9a89bb12012b116a9
Autor:
Cyprian Osinde, Wataru Sakamoto, Hiromi Kajiya-Kanegae, Islam S. Sobhy, Arthur K. Tugume, Anthony M. Nsubuga, Ivan Galis
Publikováno v:
Journal of Plant Interactions, Vol 18, Iss 1 (2023)
ABSTRACTSorghum (Sorghum bicolor (L.) Moench) is an important crop originated in Africa that shows susceptibility to herbivores. In this study, we identified two sorghum genotypes with highly contrasting levels of stem damage caused by the caterpilla
Externí odkaz:
https://doaj.org/article/71fde2286c7d4937bb2aac2b1fcc85bd
Autor:
Lukasz Kuryk, Anne-Sophie W. Møller
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 158-170 (2023)
Immunotherapy of metastatic melanoma (MM) has vastly improved the longevity of only a minority of patients. To broaden the repertoire of agents against MM, we investigated the effectiveness of locally interrupting tumor blood endothelial cell prolife
Externí odkaz:
https://doaj.org/article/61c1a196c2b7448eafc166d8e08ca866
Publikováno v:
Journal of King Saud University: Computer and Information Sciences, Vol 34, Iss 8, Pp 4743-4755 (2022)
Identification of the most prominent bio-markers or genes with high classification accuracy in the high-dimensional cancerous data, is still remained as an emerging challenge for the machine learning researchers. As this challenge has two objectives,
Externí odkaz:
https://doaj.org/article/276efc445b884651830f5bd8b66240de
Autor:
Yayi He, Haoyue Guo, Li Diao, Yu Chen, Junjie Zhu, Hiran C. Fernando, Diego Gonzalez Rivas, Hui Qi, Chunlei Dai, Xuzhen Tang, Jun Zhu, Jiawei Dai, Kan He, Dan Chan, Yang Yang
Publikováno v:
Engineering, Vol 15, Iss , Pp 102-114 (2022)
Patient-derived tumor xenografts (PDXs) are a powerful tool for drug discovery and screening in cancer. However, current studies have led to little understanding of genotype mismatches in PDXs, leading to massive economic losses. Here, we established
Externí odkaz:
https://doaj.org/article/ff5be0d86a244933aa0d0e66330b5f06
Autor:
Paul Lecker, Karanveer Johal, Alexa McGrath, John Spikes, Jake Bernstein, Victoria MacPherson, Rushil Brahmbhatt, Nada Fadl, Edgar Weyback-Liogier, Sarah Adams, Rachel Souza, E-Jine Tsai, Mark Martin, Jacquelyn Gerhart, Grezgorz Gorski, Federica De Cecco, Brian Heist, Sebastian Egberts, Mindy George-Weinstein, Arturo Bravo-Nuevo
Publikováno v:
Applied Sciences, Vol 13, Iss 22, p 12423 (2023)
Glaucoma is one of the leading causes of blindness worldwide. Decreased aqueous humor drainage causes an increase in intraocular pressure (IOP), which in turn damages the ganglion cells of the retina and optic nerve. A mouse model of glaucoma was use
Externí odkaz:
https://doaj.org/article/f291d699c7bc4875ab0ee0ef1309c85a