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Akademický článek

Engraftment of human mesenchymal stem cells in a severely immunodeficient mouse

Autor: Yuko Kato, Yusuke Ohno, Ryoji Ito, Takeshi Taketani, Yumi Matsuzaki, Satoru Miyagi

Publikováno v: Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-9 (2024)

Abstract The transplantation of human mesenchymal stromal/stem cells (hMSCs) has potential as a curative and permanent therapy for congenital skeletal diseases. However, the self-renewal and differentiation capacities of hMSCs markedly vary. Therefor

Externí odkaz: https://doaj.org/article/5e17228cd72f4829bb49f02c57a4b432

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Akademický článek

Engineering a non-oxidative glycolysis pathway in escherichia coli for high-level citramalate production

Autor: Tingting Wang, Lijuan Ding, Huiying Luo, Huoqing Huang, Xiaoyun Su, Yingguo Bai, Tao Tu, Yuan Wang, Xing Qin, Honglian Zhang, Yaru Wang, Bin Yao, Jie Zhang, Xiaolu Wang

Publikováno v: Microbial Cell Factories, Vol 23, Iss 1, Pp 1-14 (2024)

Abstract Background Methyl methacrylate (MMA) is a key precursor of polymethyl methacrylate, extensively used as a transparent thermoplastic in various industries. Conventional MMA production poses health and environmental risks; hence, citramalate s

Externí odkaz: https://doaj.org/article/533756918662444d9aa132df2df11510

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Akademický článek

Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice

Autor: Ryoji Ito, Yusuke Ohno, Yunmei Mu, Yuyo Ka, Shuko Ito, Maiko Emi-Sugie, Misa Mochizuki, Kenji Kawai, Motohito Goto, Tomoyuki Ogura, Riichi Takahashi, Akira Niwa, Tatsutoshi Nakahata, Mamoru Ito

Publikováno v: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-7 (2024)

Abstract Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human C

Externí odkaz: https://doaj.org/article/5fb3c7fe2ac54a79a530db9b5302a07c

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Akademický článek

Optimization of trans-4-hydroxyproline synthesis pathway by rearrangement center carbon metabolism in Escherichia coli

Autor: Yu Gong, Ruiqi Wang, Ling Ma, Shuo Wang, Changgeng Li, Qingyang Xu

Publikováno v: Microbial Cell Factories, Vol 22, Iss 1, Pp 1-14 (2023)

Abstract Background trans-4-Hydroxyproline (T-4-HYP) is a promising intermediate in the synthesis of antibiotic drugs. However, its industrial production remains challenging due to the low production efficiency of T-4-HYP. This study focused on desig

Externí odkaz: https://doaj.org/article/5e26f1578fe94cb9a89bb12012b116a9

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Akademický článek

Identification of quantitative trait loci associated with sorghum susceptibility to Asian stem borer damage

Autor: Cyprian Osinde, Wataru Sakamoto, Hiromi Kajiya-Kanegae, Islam S. Sobhy, Arthur K. Tugume, Anthony M. Nsubuga, Ivan Galis

Publikováno v: Journal of Plant Interactions, Vol 18, Iss 1 (2023)

ABSTRACTSorghum (Sorghum bicolor (L.) Moench) is an important crop originated in Africa that shows susceptibility to herbivores. In this study, we identified two sorghum genotypes with highly contrasting levels of stem damage caused by the caterpilla

Externí odkaz: https://doaj.org/article/71fde2286c7d4937bb2aac2b1fcc85bd

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Akademický článek

Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models

Autor: Lukasz Kuryk, Anne-Sophie W. Møller

Publikováno v: Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 158-170 (2023)

Immunotherapy of metastatic melanoma (MM) has vastly improved the longevity of only a minority of patients. To broaden the repertoire of agents against MM, we investigated the effectiveness of locally interrupting tumor blood endothelial cell prolife

Externí odkaz: https://doaj.org/article/61c1a196c2b7448eafc166d8e08ca866

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