Zobrazeno 1 - 10
of 3 682
pro vyhledávání: '"NOEL R"'
Autor:
Maxwell P. Gold, Winnie Ong, Andrew M. Masteller, David R. Ghasemi, Julie Anne Galindo, Noel R. Park, Nhan C. Huynh, Aneesh Donde, Veronika Pister, Raul A. Saurez, Maria C. Vladoiu, Grace H. Hwang, Tanja Eisemann, Laura K. Donovan, Adam D. Walker, Joseph Benetatos, Christelle Dufour, Livia Garzia, Rosalind A. Segal, Robert J. Wechsler-Reya, Jill P. Mesirov, Andrey Korshunov, Kristian W. Pajtler, Scott L. Pomeroy, Olivier Ayrault, Shawn M. Davidson, Jennifer A. Cotter, Michael D. Taylor, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized that the heterogeneity observed in MBs with sonic hed
Externí odkaz:
https://doaj.org/article/7e7b389f322c4aed99ee994b5589418d
Autor:
Cheyne Kurokawa, Sonia Agrawal, Abhisek Mitra, Elena Galvani, Shannon Burke, Ankita Varshine, Raymond Rothstein, Kevin Schifferli, Noel R. Monks, Johann Foloppe, Nathalie Silvestre, Eric Quemeneur, Christelle Demeusoit, Patricia Kleinpeter, Puja Sapra, Carl Barrett, Scott A. Hammond, Elizabeth J. Kelly, Jason Laliberte, Nicholas M. Durham, Michael Oberst, Maria A.S. Broggi
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 1, Pp 200758- (2024)
Oncolytic viruses are engineered to selectively kill tumor cells and have demonstrated promising results in early-phase clinical trials. To further modulate the innate and adaptive immune system, we generated AZD4820, a vaccinia virus engineered to e
Externí odkaz:
https://doaj.org/article/451f421c29ac474f8695a5be66804ebc
Autor:
Yuriy Baglaenko, Catriona Wagner, Vijay G. Bhoj, Petter Brodin, M. Eric Gershwin, Daniel Graham, Pietro Invernizzi, Kenneth K. Kidd, Ilya Korsunsky, Michael Levy, Andrew L. Mammen, Victor Nizet, Francisco Ramirez-Valle, Edward C. Stites, Marc S. Williams, Michael Wilson, Noel R. Rose, Virginia Ladd, Marina Sirota
Publikováno v:
Cambridge Prisms: Precision Medicine, Vol 1 (2023)
Precision Medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Autoimmune diseases are those in which the body’s natural defense system loses disc
Externí odkaz:
https://doaj.org/article/bcf797b4c46e41e2bed7e76f1a48f825
Autor:
W. Charles Kerfoot, Gary Swain, Luis M. Verissimo, Erin Johnston, Carol A. MacLennan, Daniel Schneider, Noel R. Urban
Publikováno v:
Journal of Marine Science and Engineering, Vol 11, Iss 7, p 1447 (2023)
Over a century ago, copper mills on the Keweenaw Peninsula of Lake Superior sluiced 64 million metric tonnes (MMT) of tailings into coastal waters, creating a metal-rich “halo”. Here we show that relatively small discharges can spread widely in t
Externí odkaz:
https://doaj.org/article/9872913a5d0d4675a22dc129159de314
Publikováno v:
EJVES Vascular Forum, Vol 53, Iss , Pp 30-35 (2021)
Introduction: Isolated iliac artery aneurysms are an uncommon occurrence in the absence of concurrent aortic disease in the adult population and are a rare entity in children and adolescents. Paediatric patients may present with false aneurysms less
Externí odkaz:
https://doaj.org/article/cc78f4e535d2476895ae33958e226de4
Autor:
Pierre Echaubard, Chea Thy, Soun Sokha, Set Srun, Claudia Nieto-Sanchez, Koen Peters Grietens, Noel R. Juban, Jana Mier-Alpano, Sucelle Deacosta, Mojgan Sami, Leo Braack, Bernadette Ramirez, Jeffrey Hii
Publikováno v:
Infectious Diseases of Poverty, Vol 9, Iss 1, Pp 1-12 (2020)
Abstract Background The social-ecological systems theory, with its unique conception of resilience (social-ecological systems & resilience, SESR), provides an operational framework that currently best meets the need for integration and adaptive gover
Externí odkaz:
https://doaj.org/article/e9f6f5f0ed664556923c80f17a52e5ab
Publikováno v:
Applied Sciences, Vol 12, Iss 23, p 12076 (2022)
This research bridges the gap between the quasi-static and high-strain-rate loading regimes in cross-laminated timber (CLT) by investigating two areas that have remained unstudied or elusive, i.e., rolling shear failure of CLT under impulsive, blast-
Externí odkaz:
https://doaj.org/article/c745efdac6c445cd8d43d995094c453c
Autor:
Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith, Simon J. Cook
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
BRAF or MEK1/2 inhibitors are cytostatic in melanoma and the surviving cells develop drug resistance. This study shows that the pro-survival pool is biased towards MCL1 in melanoma so that BRAF or MEK1/2 inhibitors are synthetic lethal with the MCL1
Externí odkaz:
https://doaj.org/article/03dfbb8e162440b8bfec0b14545e606c
Autor:
Mary Ann D Lansang, Marissa M Alejandria, Irwin Law, Noel R Juban, Maria Lourdes E Amarillo, Olivia T Sison, Jose Rene B Cruz, Concepcion F Ang, Joseph Adrian L Buensalido, Johanna Patricia A Cañal, Nina T Castillo-Carandang, Cynthia P Cordero, Donna Mae G Gaviola, Mary Ann J Ladia, Jacinto Blas V Mantaring, Myrna T Mendoza, Maria Sonia S Salamat, Hilton Y Lam, Marina Tadolini, Anna Marie Celina G Garfin, Philippine NTPS 2016 Group
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252240 (2021)
SettingThe 3rd national tuberculosis (TB) survey in the Philippines in 2007 reported a significant decline in the prevalence of TB. Since then, more significant investments for TB control have been made, yet TB burden estimates from routine surveilla
Externí odkaz:
https://doaj.org/article/aa206b87b30e435789890e057498d23a
Publikováno v:
Canine Genetics and Epidemiology, Vol 4, Iss 1, Pp 1-12 (2017)
Abstract Background The German Shepherd Dog (GSD) has been widely used for a variety of working roles. However, concerns for the health and welfare of the GSD have been widely aired and there is evidence that breed numbers are now in decline in the U
Externí odkaz:
https://doaj.org/article/0090aa4360a04305b89ca20c99c999b6