Zobrazeno 1 - 10
of 54
pro vyhledávání: '"NOBUHIRO SHIMOZAWA"'
Autor:
Yuki Muraoka, Yuto Iida, Hanako O. Ikeda, Sachiko Iwai, Masayuki Hata, Takeshi Iwata, Mao Nakayama, Nobuhiro Shimozawa, Yuko Katakai, Akira Kakizuka, Nagahisa Yoshimura, Akitaka Tsujikawa
Publikováno v:
Heliyon, Vol 4, Iss 5 (2018)
Age-related macular degeneration (AMD) is a leading cause of blindness among elderly people. The appearance of drusen is a clinical manifestation and a harbinger of both exudative and atrophic AMD. Recently, antibody-based medicines have been used to
Externí odkaz:
https://doaj.org/article/91d4eee18f4349b59397b63e4f0237f4
Autor:
Koji M Nishiguchi, Yu Yokoyama, Yusuke Fujii, Kosuke Fujita, Yusuke Tomiyama, Ryo Kawasaki, Toshinori Furukawa, Fumiko Ono, Nobuhiro Shimozawa, Mutsumi Togo, Michihiro Suzuki, Toru Nakazawa
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164899 (2016)
Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the development of age-related macular degeneration (AMD), one of the leading causes of blindness worl
Externí odkaz:
https://doaj.org/article/2698ee08765d4be5b24168389630a683
Autor:
Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Katsuhiko Yanagisawa, Nobuyuki Kimura
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117362 (2015)
Growing evidence suggests that diabetes mellitus (DM) is one of the strongest risk factors for developing Alzheimer's disease (AD). However, it remains unclear why DM accelerates AD pathology. In cynomolgus monkeys older than 25 years, senile plaques
Externí odkaz:
https://doaj.org/article/cab6aefe22be4dd48409f85eacc30175
Autor:
Sana Ando, Masashi Sakurai, Shusaku Shibutani, Nobuyuki Kimura, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Ryotaro Yabe, Takashi Ohama, Koichi Sato
Publikováno v:
The Journal of Biochemistry. 173:435-445
The abnormal activity of PP2A, a dominant member of type 2A serine/threonine protein phosphatase, has been implicated in the development of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). PP2A is a holoenzyme, and protein methylation
Autor:
Tomomi Nishie, Yoshio Ohta, Emi Shirai, Shogo Higaki, Nobuhiro Shimozawa, Keishi Narita, Kotoku Kawaguchi, Hideyuki Tanaka, Chika Mori, Taiga Tanaka, Masumi Hirabayashi, Hirofumi Suemori, Akira Kurisaki, Ikuo Tooyama, Shinji Asano, Sén Takeda, Tatsuyuki Takada
Publikováno v:
Genes to Cells.
Autor:
KAZUHIKO TANABE, ITARU KIMURA, HARU OKAMOTO, ZAI-LONG CHI, MASAKAZU AKAHORI, NOBUHIRO SHIMOZAWA, NOBUYUKI EBIHARA, AKIRA MURAKAMI, TAKESHI IWATA
Publikováno v:
Juntendo Medical Journal. 68:339-351
Autor:
Yoshiko Munesue, Naohide Ageyama, Nobuyuki Kimura, Ichiro Takahashi, Shunya Nakayama, Sachi Okabayashi, Yuko Katakai, Hiroshi Koie, Ken-ichi Yagami, Kazuhiro Ishii, Akira Tamaoka, Yasuhiro Yasutomi, Nobuhiro Shimozawa
Publikováno v:
Experimental Neurology. 363:114381
Publikováno v:
Experimental animals. 71(4)
This study aimed to develop a more suitable ovarian stimulation procedure for cynomolgus macaques (Macaca fascicularis). Macaques were divided into 4 groups, 7AG, 8AG, 7AN, and 8AN, according to the ovarian stimulation procedure administered (i.e., a
Publikováno v:
Journal of the American Association for Laboratory Animal Science. 60:125-132
Intrauterine sperm injection for artificial insemination is difficult in cynomolgus macaques (Macaca fascicularis) and rhesus macaques (M. mulatta) due to the complex structure of the cervical canal, which differs from that of humans. Despite the ava
Autor:
Nobuyuki Kimura, Nobuhiro Shimozawa, Naoya Ueda, Yasuhiro Yasutomi, Keiko Suzuki, Shingo Takeuchi
Publikováno v:
The American Journal of Pathology. 189:391-404
The endocytic membrane trafficking system is altered in the brains of early-stage Alzheimer disease (AD) patients, and endocytic disturbance affects the metabolism of β-amyloid (Aβ) protein, a key molecule in AD pathogenesis. It is widely accepted