Zobrazeno 1 - 10
of 1 311
pro vyhledávání: '"NNRTIs"'
Autor:
Yanying Sun, Zhenzhen Zhou, Zhongling Shi, Fabao Zhao, Minghui Xie, Zongji Zhuo, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3110-3124 (2024)
HIV-1 reverse transcriptase (RT) has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome (AIDS), but the inevitable drug resistance and side effects have always been major challenges faced by non-nucle
Externí odkaz:
https://doaj.org/article/11cdd506ac7a43449abb83e409f2a953
Autor:
Sudhir Kumar Sahoo, Prasanta Kumar Choudhury, P N Murthy, Uma Shankar Mishra, Saroj Kanta Bisoyi, Lokesh Kumar
Publikováno v:
Journal of Applied Pharmaceutical Research, Vol 12, Iss 3, Pp 119-128 (2024)
Background: The crucial aspect to consider during method development and validation, ensuring accurate, precise, and specific estimation of drug substances and drug products, is stability. Various factors, including environmental, instrumental, reage
Externí odkaz:
https://doaj.org/article/2b9149b1616c417ba0f06370a2623450
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 4906-4917 (2023)
Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66 (SI = 2019.80, S = 1.9 μg/mL), a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility
Externí odkaz:
https://doaj.org/article/9fc6b09d87c44d3a900c1f299690c817
Akademický článek
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Autor:
Zongji Zhuo, Zhao Wang, Lanlan Jing, Tao Zhang, Anchao Ge, Zhenzhen Zhou, Ying Liu, Xin Li, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9028 (2024)
Inspired by our previous work on the modification of diarylpyrimidine-typed non-nucleoside reverse transcriptase inhibitors (NNRTIs) and the reported crystallographic studies, a series of novel amino acids (analogues)-substituted thiophene[3,2-d]pyri
Externí odkaz:
https://doaj.org/article/6edd3910ff24434aa0d574a7696157ad
Autor:
Shenghua Gao, Letian Song, Yusen Cheng, Fabao Zhao, Dongwei Kang, Shu Song, Mianling Yang, Bing Ye, Wei Zhao, Yajie Tang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2747-2764 (2023)
Indolylarylsulfones (IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a unique scaffold and possess potent antiviral activity. To address the high cytotoxicity and improve safety profiles of IASs, we introduced
Externí odkaz:
https://doaj.org/article/8964cae7904a4512954b69a8af82c05c
Publikováno v:
Informatics in Medicine Unlocked, Vol 48, Iss , Pp 101512- (2024)
It is estimated that over four decades since the onset of the AIDS epidemic, a significant number of individuals have been impacted by HIV-1 infection. The latest data shows that 165,000 children were among the 1.5 million people who contracted HIV i
Externí odkaz:
https://doaj.org/article/6822581a196e4212af0c30481ad9828c
Autor:
Georgette D. Kanmogne
Publikováno v:
Cells, Vol 13, Iss 8, p 672 (2024)
Endothelial cell activation, injury, and dysfunction underlies the pathophysiology of vascular diseases and infections associated with vascular dysfunction, including human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome. Despite
Externí odkaz:
https://doaj.org/article/5458c0e3ccb34ca987cd40283795bd09
Autor:
Igor A. Khalymbadzha, Ramil F. Fatykhov, Ilya I. Butorin, Ainur D. Sharapov, Anastasia P. Potapova, Nibin Joy Muthipeedika, Grigory V. Zyryanov, Vsevolod V. Melekhin, Maria D. Tokhtueva, Sergey L. Deev, Marina K. Kukhanova, Nataliya N. Mochulskaya, Mikhail V. Tsurkan
Publikováno v:
Biomimetics, Vol 9, Iss 1, p 44 (2024)
We have designed and synthesized a series of bioinspired pyrano[2,3-f]coumarin-based Calanolide A analogs with anti-HIV activity. The design of these new calanolide analogs involved incorporating nitrogen heterocycles or aromatic groups in lieu of ri
Externí odkaz:
https://doaj.org/article/bb4f6881cd7241e0897dfbe5f9b17b6d
Akademický článek
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