Spatial Insights into Drought Severity: Multi-Index Assessment in Małopolska, Poland, via Satellite Observations

Autor: Jakub Staszel, Michał Lupa, Katarzyna Adamek, Michał Wilkosz, Adriana Marcinkowska-Ochtyra, Adrian Ochtyra

Publikováno v: Remote Sensing, Vol 16, Iss 5, p 836 (2024)

This study focuses on the assessment of drought severity, employing a comparative analysis between the normalized multi-band drought index (NMDI; calculated using Sentinel-2 imagery) and the combined drought indicator (CDI). The research aims to pinp

Externí odkaz: https://doaj.org/article/faa8a8c2bcde4f99a701239058f0588a

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Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers

Autor: Jing Wang, Pan Tong, Monique B. Nilsson, Tina Cascone, Erik P. Sulman, Alissa Poteete, Piyada Sitthideatphaiboon, Faye M. Johnson, Shaohua Peng, Li Shen, John V. Heymach, Naoto Morikawa, Qiuyu Wu, Jean-Christophe Bourdon, Phillip Jones, Fahao Zhang, Jayanthi Gudikote, Lerong Li

Publikováno v: The Journal of Biological Chemistry

Inactivation of p53 is present in almost every tumor, and hence, p53-reactivation strategies are an important aspect of cancer therapy. Common mechanisms for p53 loss in cancer include expression of p53-negative regulators such as MDM2, which mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141972075328430857ff8891a8eb428e
http://europepmc.org/articles/PMC8569473

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Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies

Autor: Sébastien Durand, Edouard Bertrand, David S. Grierson, Florence Mahuteau-Betzer, Fabrice Lejeune, Nicolas Cougot, Jamal Tazi, Chi-Hung Nguyen

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2007, 178 (7), pp.1145-60. ⟨10.1083/jcb.200611086⟩
Journal of Cell Biology, Rockefeller University Press, 2007, 178 (7), pp.1145-1160. ⟨10.1083/jcb.200611086⟩

International audience; In mammals, nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs harboring a premature termination codon, in order to prevent the synthesis of truncated proteins. To gain insight into NMD mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659300eb1b00e4cbf3ee64b0f7ab8359
http://europepmc.org/articles/PMC2064650