A novel common variant in DCST2 is associated with length in early life and height in adulthood

Autor: Rj, Valk, Kreiner-Møller E, Mn, Kooijman, Guxens M, Stergiakouli E, Sääf A, Jp, Bradfield, Geller F, Mg, Hayes, Dl, Cousminer, Körner A, Thiering E, Ja, Curtin, Myhre R, Huikari V, Joro R, Kerkhof M, Nm, Warrington, Pitkänen N, Ntalla I, Horikoshi M, Veijola R, Rm, Freathy, Yy, Teo, Sj, Barton, Dm, Evans, Jp, Kemp, St Pourcain B, Sm, Ring, Gd, Smith, Bergström A, Kull I, Hakonarson H, Fd, Mentch, Bisgaard H, Chawes B, Stokholm J, Waage J, Eriksen P, Sevelsted A, Melbye M, Cm, Duijn, Medina-Gomez C, Hofman A, Jc, Jongste, Hr, Taal, Ag, Uitterlinden, Ll, Armstrong, Eriksson J, Palotie A, Bustamante M, Estivill X, Jr, Gonzalez, Llop S, Kiess W, Mahajan A, Flexeder C, Cm, Tiesler, Cs, Murray, Simpson A, Magnus P, Sengpiel V, Al, Hartikainen, Keinanen-Kiukaanniemi S, Lewin A, Da Silva Couto Alves A, Ai, Blakemore, Jl, Buxton, Kaakinen M, Rodriguez A, Sebert S, Vaarasmaki M, Lakka T, Lindi V, Gehring U, Ds, Postma, Ang W, Jp, Newnham, Lp, Lyytikäinen, Pahkala K, Ot, Raitakari, Panoutsopoulou K, Zeggini E, Di, Boomsma, Groen-Blokhuis M, Ilonen J, Franke L, Jn, Hirschhorn, Th, Pers, Liang L, Huang J, Hocher B, Knip M, Sm, Saw, Jw, Holloway, Melén E, Sf, Grant, Feenstra B, Wl, Lowe, Widén E, Sergeyev E, Grallert H, Adnan Custovic, Jacobsson B, Jarvelin MR, Atalay M, Gh, Koppelman, Ce, Pennell, Niinikoski H, Gv, Dedoussis, Mi, Mccarthy, Tm, Frayling, Sunyer J, Nj, Timpson, Rivadeneira F, Bønnelykke K, Vw, Jaddoe

Publikováno v: Europe PubMed Central
van der Valk, R J P, Kreiner-Moller, E, Kooijman, M N, Guxens, M, Stergiakouli, E, Saaf, A, Bradfield, J P, Geller, F, Hayes, M G, Cousminer, D L, Koerner, A, Thiering, E, Curtin, J A, Myhre, R, Huikari, V, Joro, R, Kerkhof, M, Warrington, N M, Pitkanen, N, Ntalla, I, Horikoshi, M, Veijola, R, Freathy, R M, Teo, Y, Barton, S J, Evans, D M, Kemp, J P, St Pourcain, B, Ring, S M, Smith, G D, Bergstrom, A, Kull, I, Hakonarson, H, Mentch, F D, Bisgaard, H, Chawes, B, Stokholm, J, Waage, J, Eriksen, P, Sevelsted, A, Melbye, M, van Duijn, C M, Medina-Gomez, C, Hofman, A, de Jongste, J C, Taal, H R, Uitterlinden, A G, Armstrong, L L, Eriksson, J, Palotie, A, Bustamante, M, Estivill, X, Gonzalez, J R, Llop, S, Kiess, W, Mahajan, A, Flexeder, C, Tiesler, C M T, Murray, C S, Simpson, A, Magnus, P, Sengpiel, V, Hartikainen, A, Keinanen-Kiukaanniemi, S, Lewin, A, Alves, A D S C, Blakemore, A I, Buxton, J L, Kaakinen, M, Rodriguez, A, Sebert, S, Vaarasmaki, M, Lakka, T, Lindi, V, Gehring, U, Postma, D S, Ang, W, Newnham, J P, Lyytikainen, L, Pahkala, K, Raitakari, O T, Panoutsopoulou, K, Zeggini, E, Boomsma, D I, Groen-Blokhuis, M M, Ilonen, J, Franke, L, Hirschhorn, J N, Pers, T H, Liang, L, Huang, J, Hocher, B, Knip, M, Saw, S, Holloway, J W, Melen, E, Grant, S F A, Feenstra, B, Lowe, W L, Widen, E, Sergeyev, E, Grallert, H, Custovic, A, Jacobsson, B, Jarvelin, M, Atalay, M, Koppelman, G H, Pennell, C E, Niinikoski, H, Dedoussis, G V, McCarthy, M I, Frayling, T M, Sunyer, J, Timpson, N J, Rivadeneira, F, Bonnelykke, K & Jaddoe, V W V 2015, ' A novel common variant in DCST2 is associated with length in early life and height in adulthood ', Human Molecular Genetics, vol. 24, no. 4, pp. 1155-1168 . https://doi.org/10.1093/hmg/ddu510
Hum. Mol. Genet. 24, 1155-1168 (2015)
Human Molecular Genetics
Human Molecular Genetics, 24(4), 1155-1168. Oxford University Press

Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a16d83a298e23e3af7006697fd3c8c53
http://europepmc.org/abstract/med/25281659

No Evidence of Interaction Between FADS2 Genotype and Breastfeeding on Cognitive or Other Traits in the UK Biobank.

Autor: Centorame G; Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, 306 Carmody Road, St Lucia, QLD, 4072, Australia. g.centorame@uq.edu.au.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. g.centorame@uq.edu.au.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. g.centorame@uq.edu.au., Warrington NM; Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, 306 Carmody Road, St Lucia, QLD, 4072, Australia.; Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia.; Department of Public Health and Nursing, K. G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Wang G; Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, 306 Carmody Road, St Lucia, QLD, 4072, Australia., Davey Smith G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Evans DM; Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, 306 Carmody Road, St Lucia, QLD, 4072, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia.

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DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits.

Autor: Hwang LD; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia. d.hwang@uq.edu.au., Cuellar-Partida G; Gilead Sciences, Inc, Foster City, CA, USA., Yengo L; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia., Zeng J; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia., Toivonen J; Finnish Red Cross Blood Service, Vantaa, Finland., Arvas M; Finnish Red Cross Blood Service, Vantaa, Finland., Beaumont RN; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Freathy RM; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Moen GH; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; The Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia., Warrington NM; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; The Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia., Evans DM; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia. d.evans1@uq.edu.au.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. d.evans1@uq.edu.au.; The Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia. d.evans1@uq.edu.au.

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A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans.

Autor: Moksnes MR; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway. marta.r.moksnes@ntnu.no., Hansen AF; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway., Wolford BN; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway., Thomas LF; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; BioCore-Bioinformatics Core Facility, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Rasheed H; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway., Simić A; Department of Chemistry, NTNU-Norwegian University of Science and Technology, Trondheim, Norway., Bhatta L; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway., Brantsæter AL; Department of Food Safety, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Magnus P; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Njølstad PR; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway., Andreassen OA; NORMENT Centre, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Syversen T; Department of Neuroscience, NTNU-Norwegian University of Science and Technology, Trondheim, Norway., Zheng J; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Shanghai Digital Medicine Innovation Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK., Fritsche LG; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Evans DM; Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia.; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Warrington NM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia.; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Nøst TH; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway., Åsvold BO; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Flaten TP; Department of Chemistry, NTNU-Norwegian University of Science and Technology, Trondheim, Norway., Willer CJ; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Hveem K; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Levanger, Norway., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway. ben.brumpton@ntnu.no.; HUNT Research Centre, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Levanger, Norway. ben.brumpton@ntnu.no.; Clinic of Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway. ben.brumpton@ntnu.no.

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Meta-regression of genome-wide association studies to estimate age-varying genetic effects.

Autor: Pagoni P; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK. panagiota.pagoni@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. panagiota.pagoni@bristol.ac.uk., Higgins JPT; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Stergiakouli E; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Warrington NM; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.; Frazer Institute, University of Queensland, Brisbane, QLD, Australia.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Morris TT; Centre for Longitudinal Studies, Social Research Institute, University College London, London, UK., Tilling K; MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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