Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture

Autor: LJ Smith, JA Chiaro, NL Nerurkar, DH Cortes, SD Horava, NM Hebela, RL Mauck, GR Dodge, DM Elliott

Publikováno v: European Cells & Materials, Vol 22, Pp 291-301 (2011)

Intervertebral disc degeneration is characterized by a cascade of cellular, biochemical and structural changes that may lead to functional impairment and low back pain. Interleukin-1 beta (IL-1β) is strongly implicated in the etiology of disc degene

Externí odkaz: https://doaj.org/article/70a26d867f1e4194b50076758347ab54

Hox gene activity directs physical forces to differentially shape chick small and large intestinal epithelia.

Autor: Gill HK; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Yin S; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA., Nerurkar NL; The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA., Lawlor JC; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Lee C; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Huycke TR; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA., Mahadevan L; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: lm@seas.harvard.edu., Tabin CJ; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: tabin@genetics.med.harvard.edu.

Publikováno v: Developmental cell [Dev Cell] 2024 Aug 01. Date of Electronic Publication: 2024 Aug 01.

Application of tissue-scale tension to avian epithelia in vivo to study multiscale mechanical properties and inter-germ layer coupling.

Autor: Oikonomou P; Department of Biomedical Engineering, Columbia University, New York NY 10027., Calvary L; Department of Biomedical Engineering, Columbia University, New York NY 10027., Cirne HC; Department of Biomedical Engineering, Columbia University, New York NY 10027., Welch AE; Department of Biomedical Engineering, Columbia University, New York NY 10027., Durel JF; Department of Biomedical Engineering, Columbia University, New York NY 10027., Powell O; Department of Biomedical Engineering, Columbia University, New York NY 10027., Nerurkar NL; Department of Biomedical Engineering, Columbia University, New York NY 10027.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 06. Date of Electronic Publication: 2024 Apr 06.

Elastic fibers define embryonic tissue stiffness to enable buckling morphogenesis of the small intestine.

Autor: Loffet EA; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Durel JF; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Gao J; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Kam R; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Lim H; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA., Nerurkar NL; Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA. Electronic address: nln2113@columbia.edu.

Publikováno v: Biomaterials [Biomaterials] 2023 Dec; Vol. 303, pp. 122405. Date of Electronic Publication: 2023 Nov 17.

Editorial: Special issue on synthetic developmental biology.

Autor: Nerurkar NL; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. Electronic address: nln2113@columbia.edu.

Publikováno v: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2023 May 30; Vol. 141, pp. 1-2. Date of Electronic Publication: 2022 Aug 11.