Zobrazeno 1 - 10
of 248
pro vyhledávání: '"NKp44"'
NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma
Autor:
Yudai Murayama, Yasushi Kasahara, Nobuhiro Kubo, Chansu Shin, Masaru Imamura, Naoki Oike, Takashi Ariizumi, Akihiko Saitoh, Minori Baba, Tomohiro Miyazaki, Yuko Suzuki, Yiwei Ling, Shujiro Okuda, Keichiro Mihara, Akira Ogose, Hiroyuki Kawashima, Chihaya Imai
Publikováno v:
Translational Oncology, Vol 25, Iss , Pp 101521- (2022)
Background: T-cell receptor-engineered T-cell therapies have achieved promising response rates against synovial sarcoma in clinical trials, but their applicability is limited owing to the HLA matching requirement. Chimeric antigen receptor (CAR) can
Externí odkaz:
https://doaj.org/article/c609994a7bb64a339226a58c982ae86f
Akademický článek
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Autor:
Kerstin H. Mair, Assiatu J. Crossman, Bettina Wagner, Susanna Babasyan, Leela Noronha, Patricia Boyd, Dante Zarlenga, Maria Stadler, Katinka A. van Dongen, Wilhelm Gerner, Armin Saalmüller, Joan K. Lunney
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cells have been studied extensively in humans and mice for their vital role in the vertebrate innate immune system. They are known to rapidly eliminate tumors or virus infected cells in an immune response utilizing their lytic pro
Externí odkaz:
https://doaj.org/article/33c01f50dd4f46d682191de566333d6c
Akademický článek
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Autor:
Muhammed Iraqi, Priyanka Bolel, Rhitajit Sarkar, Baisali Bhattacharya, Muhammad Abu Ahmad, Avishay Edri, Laila C. Roisman, Moshe Elkabets, Walid Shalata, Nir Peled, Angel Porgador
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14054 (2022)
Lung cancer cells in the tumor microenvironment facilitate immune evasion that leads to failure of conventional chemotherapies, despite provisionally decided on the genetic diagnosis of patients in a clinical setup. The current study follows three lu
Externí odkaz:
https://doaj.org/article/249f0a43fe804b55809a5a0dfe4339ae
Autor:
Muhammed Iraqi, Avishay Edri, Yariv Greenshpan, Oron Goldstein, Noa Ofir, Priyanka Bolel, Muhammad Abu Ahmad, Miri Zektser, Kerry S. Campbell, Ory Rouvio, Roi Gazit, Angel Porgador
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4717 (2022)
Multiple Myeloma (MM) is a devastating malignancy that evades immune destruction using multiple mechanisms. The NKp44 receptor interacts with PCNA (Proliferating Cell Nuclear Antigen) and may inhibit NK cells’ functions. Here we studied in vitro th
Externí odkaz:
https://doaj.org/article/f163f63997ee48638e6fe3a7bfd223c8
Autor:
Yasushi Kasahara, Chansu Shin, Nobuhiro Kubo, Keichiro Mihara, Haruko Iwabuchi, Takayuki Takachi, Masaru Imamura, Akihiko Saitoh, Chihaya Imai
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 7, Pp n/a-n/a (2020)
Abstract Objectives One of the reasons as to why chimeric antigen receptors (CAR)‐T cell therapy for malignancies other than CD19‐ or BCMA‐positive tumors has yet to produce remarkable progress is the paucity of targetable antigens. NKp44 is on
Externí odkaz:
https://doaj.org/article/2c263e5bfe4048dc925fc78e6bafae1d
Autor:
Yotam E. Bar-Ephraim, Ferry Cornelissen, Natalie Papazian, Tanja Konijn, Remco M. Hoogenboezem, Mathijs A. Sanders, Bart A. Westerman, Mehmet Gönültas, Jaap Kwekkeboom, Joke M.M. Den Haan, Rogier M. Reijmers, Reina E. Mebius, Tom Cupedo
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 823-833 (2017)
A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood. Here, we employed an unbiased cross-tissue transcriptomic app
Externí odkaz:
https://doaj.org/article/2052fe975f11466bbffd54387d2953fa
Akademický článek
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Autor:
Robert J. Canter, William J. Murphy
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-3 (2018)
Abstract Immunotherapy is rapidly becoming the fourth arm of cancer treatment, and breakthrough successes have been observed in multiple malignancies. However, despite the potential for impressive anti-tumor effects, on average, only 25% of patients
Externí odkaz:
https://doaj.org/article/0af1e88149d941758a5e8db5fb361d8b