Zobrazeno 1 - 10
of 30 997
pro vyhledávání: '"NK-cells"'
Autor:
Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt, Wolfgang Merkt
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-8 (2024)
Abstract Objective The high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on the disappearance of autoantibodies. Here we investigated effects of CAR-T cells on the innate immune system
Externí odkaz:
https://doaj.org/article/36e1a80569564abc9a7e8ecb3eb2ee95
Autor:
Mohamad K. Hammoud, Celina Meena, Raimund Dietze, Nathalie Hoffmann, Witold Szymanski, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract Background High levels of the polyunsaturated fatty acid arachidonic acid (AA) within the ovarian carcinoma (OC) microenvironment correlate with reduced relapse-free survival. Furthermore, OC progression is tied to compromised immunosurveill
Externí odkaz:
https://doaj.org/article/b5b59f79e7714241a2f9d27ed2f57ac0
Autor:
I. G. Vorobyova, E. V. Abakushina
Publikováno v:
Медицинская иммунология, Vol 26, Iss 6, Pp 1163-1176 (2024)
A major issue in treatment of solid malignancies is associated with multiplicity and rapid adaptation of immunosuppressive effects exerted by immune cells reprogrammed by the tumor. Tumor-associated macrophages (TAM), neutrophils, and tumor-infiltrat
Externí odkaz:
https://doaj.org/article/3f55b6b0dc884e71b5f269ef1823e71e
Autor:
A. A. Davydova, V. A. Mikhailova, A. A. Kovaleva, P. V. Grebenkina, E. V. Tyshchuk, M. S. Zementova, O. N. Bespalova, D. I. Sokolov, S. A. Selkov
Publikováno v:
Медицинская иммунология, Vol 26, Iss 6, Pp 1301-1308 (2024)
Natural killer cells (NK cells) are a population of innate immune lymphocytes capable of cytolysis of infected or transformed cells without prior sensitization. Natural killers are detected in various organs and tissues and may differ in phenotypic a
Externí odkaz:
https://doaj.org/article/acacd701813f42f9b894b6591d7f756b
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Gastrointestinal (GI) cancers represent a significant health burden worldwide. Their incidence continues to increase, and their management remains a clinical challenge. Chimeric antigen receptor (CAR) natural killer (NK) cells hav
Externí odkaz:
https://doaj.org/article/87463dc37a534759965370afa0d40bae
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract The serine/threonine/tyrosine kinase 1 (STYK1) is a receptor protein-tyrosine kinase (RPTK)-like molecule that is detected in several human organs. STYK1 plays an important role in promoting tumorigenesis and metastasis in various cancers. B
Externí odkaz:
https://doaj.org/article/dc5503756b1941199e25a65e1aab4472
Publikováno v:
Cancer Management and Research, Vol Volume 16, Pp 1425-1433 (2024)
Ji Yang,1,* Zhenyu Ding,2,* Ying Yu,1 Junde Liu,1 Shuang Song,1 Zhendong Zheng,2 Huiying Yu1 1Basic Medicine Laboratory, General Hospital of Northern Theater Command, Shenyang, 110016, People’s Republic of China; 2Department of Clinical Onc
Externí odkaz:
https://doaj.org/article/a252a2a254ed4661a979861fec15c2bd
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 891-896 (2024)
During infection with cytomegalovirus (HCMV), the content of so-called adaptive NK cells with the CD57+NKG2C+ phenotype increases in the peripheral blood, capable of exhibiting specialized functional activity aimed at controlling the infection upon r
Externí odkaz:
https://doaj.org/article/6e05e1788a984c39bb3b433c479837ba
Autor:
Zilin Tan, Liangjie Tian, Yang Luo, Kexin Ai, Xuehua Zhang, Haitao Yuan, Jinfan Zhou, Guangyao Ye, Shuofei Yang, Ming Zhong, Gaohua Li, Yanan Wang
Publikováno v:
Bioactive Materials, Vol 44, Iss , Pp 236-255 (2025)
Colorectal cancer (CRC) recurrence post-surgery remains a major challenge. While Chimeric Antigen Receptor (CAR)-engineered natural killer (NK) cells hold immense therapeutic potential, their intratumoral infiltration ability remains limited, hamperi
Externí odkaz:
https://doaj.org/article/8c14feec8a474790a1e702c2b275fdd9
