Zobrazeno 1 - 10
of 97
pro vyhledávání: '"NK cell expansion"'
Autor:
Jhih-Ni Lin, Che-Yung Kuan, Chia-Ting Chang, Zhi-Yu Chen, Wei-Ting Kuo, Jason Lin, Yu-Ying Lin, I.-Hsuan Yang, Feng-Huei Lin
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract The NK-92MI cell line has displayed significant promise in clinical trials for cancer treatment. However, challenges persist in obtaining sufficient cell quantities and achieving optimal cytotoxicity. The proliferation of natural killer (NK)
Externí odkaz:
https://doaj.org/article/66ae74cd7e604985826b4b94472c96b9
Autor:
David S.J. Allan, Chuanfeng Wu, Ryland D. Mortlock, Mala Chakraborty, Katayoun Rezvani, Jan K. Davidson-Moncada, Cynthia E. Dunbar, Richard W. Childs
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 74-87 (2023)
Multiple clinical trials exploring the potential of adoptive natural killer (NK) cell therapy for cancer have employed ex vivo expansion using feeder cells to obtain large numbers of NK cells. We have previously utilized the rhesus macaque model to c
Externí odkaz:
https://doaj.org/article/1edf27f82c9247a59d26f5b1e82ee10b
Autor:
Nadezhda A. Alekseeva, Maria A. Streltsova, Julia D. Vavilova, Maria O. Ustiuzhanina, Anastasia I. Palamarchuk, Anna A. Boyko, Nikita D. Timofeev, Alexey I. Popodko, Elena I. Kovalenko
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 133 (2024)
Human cytomegalovirus (HCMV)-specific adaptive NK cells are capable of recognizing viral peptides presented by HLA-E on infected cells via the NKG2C receptor. Using retroviral transduction, we have generated a K562-cell-based line expressing HLA-E in
Externí odkaz:
https://doaj.org/article/ef8f40aa4c99438caa2fcae9d7d248cb
Akademický článek
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Autor:
Maryam Hejazi, Congcong Zhang, Sabrina B. Bennstein, Vera Balz, Sarah B. Reusing, Melissa Quadflieg, Keven Hoerster, Stefan Heinrichs, Helmut Hanenberg, Sebastian Oberbeck, Marcus Nitsche, Sophie Cramer, Rita Pfeifer, Pranav Oberoi, Heiko Rühl, Johannes Oldenburg, Peter Brossart, Peter A. Horn, Florian Babor, Winfried S. Wels, Johannes C. Fischer, Nina Möker, Markus Uhrberg
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The generation and expansion of functionally competent NK cells in vitro is of great interest for their application in immunotherapy of cancer. Since CD33 constitutes a promising target for immunotherapy of myeloid malignancies, NK cells expressing a
Externí odkaz:
https://doaj.org/article/4c25f962481b401c9f9ed4e85508f881
Autor:
Erica L. Heipertz, Evan R. Zynda, Tor Espen Stav-Noraas, Andrew D. Hungler, Shayne E. Boucher, Navjot Kaur, Mohan C. Vemuri
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily located in peripheral circulation and lymphoid tissues. They kill virally infected and malignant cells through a balancing play of inhibitory and stimul
Externí odkaz:
https://doaj.org/article/2d689492b6a441a5a28169b487703b68
Autor:
Meng Guo, Chen Sun, Yuping Qian, Liye Zhu, Na Ta, Guangjian Wang, Jianming Zheng, Fengfu Guo, Yanfang Liu
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Adoptive natural killer (NK) cell transfer has been demonstrated to be a promising immunotherapy approach against malignancies, but requires the administration of sufficient activated cells for treatment effectiveness. However, the paucity of clinica
Externí odkaz:
https://doaj.org/article/bc390b4e149a4f7bbb7fc9b907fd555c
Autor:
Enli Liu, Sonny O. T. Ang, Lucila Kerbauy, Rafet Basar, Indreshpal Kaur, Mecit Kaplan, Li Li, Yijiu Tong, May Daher, Emily L. Ensley, Nadima Uprety, Ana Karen Nunez Cortes, Ryan Z. Yang, Ye Li, Hila Shaim, Francia Reyes Silva, Paul Lin, Vakul Mohanty, Sunil Acharya, Mayra Shanley, Luis Muniz-Feliciano, Pinaki P. Banerjee, Ken Chen, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer (NK) cells are innate lymphocytes recognized for their important role against tumor cells. NK cells expressing chimeric antigen receptors (CARs) have enhanced effector function against various type of cancer and are attractive contende
Externí odkaz:
https://doaj.org/article/84d792fb6aac47afad9d795bd2fc9ffe
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Mira M. Shenouda, Amy Gillgrass, Tina Nham, Richard Hogg, Amanda J. Lee, Marianne V. Chew, Mahsa Shafaei, Craig Aarts, Dean A. Lee, John Hassell, Anita Bane, Sukhbinder Dhesy-Thind, Ali A. Ashkar
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-14 (2017)
Abstract Background Natural killer (NK) cells play a critical role in cancer immunosurveillance. Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of activated NK cells from a small volume of peripheral blood. We
Externí odkaz:
https://doaj.org/article/e54463b04cb049b2a8ca924521f7ce2a