Zobrazeno 1 - 10
of 68
pro vyhledávání: '"NK cell engager"'
Autor:
Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTNatural killer (NK) cells emerged as a promising effector population that can be harnessed for anti-tumor therapy. In this work, we constructed NK cell engagers (NKCEs) based on NKp30-targeting single domain antibodies (sdAbs) that redirect t
Externí odkaz:
https://doaj.org/article/dab9f66e27944e228e065c4ff4d03f51
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-20 (2023)
Abstract Immune cell engagers are engineered antibodies with at least one arm binding a tumor-associated antigen and at least another one directed against an activating receptor in immune effector cells: CD3 for recruitment of T cells and CD16a for N
Externí odkaz:
https://doaj.org/article/753183316192449f81abf0e45f4814e5
Autor:
Xinghui Xiao, Ying Cheng, Xiaodong Zheng, Yuhang Fang, Yu Zhang, Rui Sun, Zhigang Tian, Haoyu Sun
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/d72bcd9a1eee4b7f890a00448e117f9f
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 2 (2023)
Monoclonal antibody-based targeted therapies have greatly improved treatment options for patients by binding to the innate immune system. However, the long-term efficacy of such antibodies is limited by mechanisms of drug resistance. Over the last 50
Externí odkaz:
https://doaj.org/article/ce115b5436b949848bb82934ebb799f4
Publikováno v:
Molecules, Vol 29, Iss 5, p 1140 (2024)
Valued for their ability to rapidly kill multiple tumor cells in succession as well as their favorable safety profile, NK cells are of increasing interest in the field of immunotherapy. As their cytotoxic activity is controlled by a complex network o
Externí odkaz:
https://doaj.org/article/68cfee385c1a47cf8094176669399c9c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in immunity by killing virally infected or tumor cells and secreting cytokines and chemokines. NK cell-mediated immunotherapy has emerged as a promising approach f
Externí odkaz:
https://doaj.org/article/2c9f247d1d2f47a99b7f3431d5c96bd2
Autor:
Xinghui Xiao, Ying Cheng, Xiaodong Zheng, Yuhang Fang, Yu Zhang, Rui Sun, Zhigang Tian, Haoyu Sun
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Bispecific antibodies have attracted more attention in recent years for the treatment of tumors, in which most of them target CD3, which mediates the killing of tumor cells by T cells. However, T-cell engager may cause serious side effects, including
Externí odkaz:
https://doaj.org/article/6ca2841a6efa48daa92da9074a85e59b
Autor:
Julia Harwardt, Stefania C. Carrara, Jan P. Bogen, Katrin Schoenfeld, Julius Grzeschik, Björn Hock, Harald Kolmar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules. Here we report for the first time the construction of t
Externí odkaz:
https://doaj.org/article/9fb531027f17410a9441b28858737aba
Autor:
Desislava Yanakieva, Lukas Pekar, Andreas Evers, Markus Fleischer, Stephan Keller, Dirk Mueller-Pompalla, Lars Toleikis, Harald Kolmar, Stefan Zielonka, Simon Krah
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by t
Externí odkaz:
https://doaj.org/article/b8dabdca29ac45818daecc26e6f0571c
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