Zobrazeno 1 - 10
of 133
pro vyhledávání: '"NIH/NCI"'
Autor:
Tukiainen, Taru, Villani, Alexandra-Chloé, Yen, Angela, Rivas, Manuel A, Marshall, Jamie L, Satija, Rahul, Aguirre, Matt, Gauthier, Laura, Fleharty, Mark, Kirby, Andrew, Cummings, Beryl B, Castel, Stephane E, Karczewski, Konrad J, Aguet, François, Byrnes, Andrea, GTEx Consortium, Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group, Statistical Methods groups—Analysis Working Group, Enhancing GTEx (eGTEx) groups, NIH Common Fund, NIH/NCI, NIH/NHGRI, NIH/NIMH, NIH/NIDA, Biospecimen Collection Source Site—NDRI, Biospecimen Collection Source Site—RPCI, Biospecimen Core Resource—VARI, Brain Bank Repository—University of Miami Brain Endowment Bank, Leidos Biomedical—Project Management, ELSI Study, Genome Browser Data Integration &Visualization—EBI, Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz, Lappalainen, Tuuli, Regev, Aviv, Ardlie, Kristin G, Hacohen, Nir, MacArthur, Daniel G
Publikováno v:
Nature, vol 550, iss 7675
X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to one-third of X-chromosomal g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::0a24cb9a9dc84dd453f14933ec92f26e
https://escholarship.org/uc/item/3j47t40b
https://escholarship.org/uc/item/3j47t40b
Autor:
Li, Xin, Kim, Yungil, Tsang, Emily K, Davis, Joe R, Damani, Farhan N, Chiang, Colby, Hess, Gaelen T, Zappala, Zachary, Strober, Benjamin J, Scott, Alexandra J, Li, Amy, Ganna, Andrea, Bassik, Michael C, Merker, Jason D, GTEx Consortium, Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group, Statistical Methods groups—Analysis Working Group, Enhancing GTEx (eGTEx) groups, NIH Common Fund, NIH/NCI, NIH/NHGRI, NIH/NIMH, NIH/NIDA, Biospecimen Collection Source Site—NDRI, Biospecimen Collection Source Site—RPCI, Biospecimen Core Resource—VARI, Brain Bank Repository—University of Miami Brain Endowment Bank, Leidos Biomedical—Project Management, ELSI Study, Genome Browser Data Integration &Visualization—EBI, Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz, Hall, Ira M, Battle, Alexis, Montgomery, Stephen B
Publikováno v:
Nature, vol 550, iss 7675
Rare genetic variants are abundant in humans and are expected to contribute to individual disease risk. While genetic association studies have successfully identified common genetic variants associated with susceptibility, these studies are not pract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::1bf49e01e92b38495418fe06bd9eb268
https://escholarship.org/uc/item/8n25b8s7
https://escholarship.org/uc/item/8n25b8s7
Autor:
GTEx Consortium, Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group, Statistical Methods groups—Analysis Working Group, Enhancing GTEx (eGTEx) groups, NIH Common Fund, NIH/NCI, NIH/NHGRI, NIH/NIMH, NIH/NIDA, Biospecimen Collection Source Site—NDRI, Biospecimen Collection Source Site—RPCI, Biospecimen Core Resource—VARI, Brain Bank Repository—University of Miami Brain Endowment Bank, Leidos Biomedical—Project Management, ELSI Study, Genome Browser Data Integration &Visualization—EBI, Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz, Lead analysts, Laboratory, Data Analysis &Coordinating Center (LDACC), NIH program management, Biospecimen collection, Pathology, eQTL manuscript working group, Battle, Alexis, Brown, Christopher D, Engelhardt, Barbara E, Montgomery, Stephen B
Publikováno v:
Nature, vol 550, iss 7675
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a32888571103653ffb9f933e5a25b832
https://escholarship.org/uc/item/24r749n7
https://escholarship.org/uc/item/24r749n7
Autor:
Davalos, Verónica, Lovell, Claudia, von Itter, Richard, Dolgalev, Igor, Agrawal, Praveen, Baptiste, Gillian, Kahler, David, Sokolova, Elena, Moran, Sebastian, Piqué, Laia, Vega-Saenz de Miera, Eleazar, Fontanals-Cirera, Barbara, Karz, Alcida, Tsirigos, Aristotelis, Yun, Chi, Darvishian, Farbod, Etchevers, Heather, Osman, Iman, Esteller, Manel, Schober, Markus, Hernando, Eva
Publikováno v:
Nature Communications
Nature Communications, In press, 14 (1), pp.1867. ⟨10.1038/s41467-023-36967-2⟩
Nature Communications, In press, 14 (1), pp.1867. ⟨10.1038/s41467-023-36967-2⟩
International audience; Metastatic melanoma develops once transformed melanocytic cells begin to de-differentiate into migratory and invasive melanoma cells with neural crest cell (NCC)-like and epithelial-tomesenchymal transition (EMT)-like features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3430::84b36dc97288bc875930599b2fd98021
https://hal-amu.archives-ouvertes.fr/hal-04007075
https://hal-amu.archives-ouvertes.fr/hal-04007075
Autor:
Mehmet Kemal Samur, Hervé Avet-Loiseau, Kristen Cowens, Randie E White, Gullu Gorgun, Florence Magrangeas, Giada Bianchi, David M. Dorfman, Jacob P. Laubach, Rikio Suzuki, Noopur Raje, Ahaana Singh, Nikhil C. Munshi, Stephane Minvielle, Steven Paula, Teru Hideshima, Shohei Kikuchi, Julie E. Anderson, Yu-Tzu Tai, Paul G. Richardson, Kenneth C. Anderson, Takeshi Harada, Hiroto Ohguchi
Publikováno v:
Clinical Cancer Research
Clinical Cancer Research, 2015, 21, pp.4607-4625. ⟨10.1158/1078-0432.CCR-15-0200⟩
Clinical Cancer Research, American Association for Cancer Research, 2015, 21, pp.4607-4625. ⟨10.1158/1078-0432.CCR-15-0200⟩
Clinical Cancer Research, 2015, 21, pp.4607-4625. ⟨10.1158/1078-0432.CCR-15-0200⟩
Clinical Cancer Research, American Association for Cancer Research, 2015, 21, pp.4607-4625. ⟨10.1158/1078-0432.CCR-15-0200⟩
Purpose: PD-1/PD-L1 signaling promotes tumor growth while inhibiting effector cell–mediated antitumor immune responses. Here, we assessed the impact of single and dual blockade of PD-1/PD-L1, alone or in combination with lenalidomide, on accessory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5373debfd8ef9fac6d6b54024a2ef4
https://www.hal.inserm.fr/inserm-02536335/file/Magrangeas2015Eq11.pdf
https://www.hal.inserm.fr/inserm-02536335/file/Magrangeas2015Eq11.pdf
Autor:
Le Tong, Carlos Jiménez-Cortegana, Apple H.M. Tay, Stina Wickström, Lorenzo Galluzzi, Andreas Lundqvist
Publikováno v:
Molecular cancer. 21(1)
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic activity, have recently attracted attention as potential anticancer therapeutics. While NK cells mediate encouraging responses in patients with leukemia, the therap
Autor:
Ribault, Alexandre, Benadjaoud, Mohamed Amine, Squiban, Claire, Arnaud, Laurent, Judicone, Coralie, Leroyer, Aurélie, Rousseau, Alexandra, Huet, Christelle, Guha, Chandan, Benderitter, Marc, Lacroix, Romaric, Flamant, Stephane, Chen, Emily, Simon, Jean-Marc, Tamarat, Radia
Publikováno v:
Scientific Reports
Scientific Reports, 2023, 13 (1), pp.2033. ⟨10.1038/s41598-022-21726-y⟩
Scientific Reports, 2023, 13 (1), pp.2033. ⟨10.1038/s41598-022-21726-y⟩
In a large retrospective study, we assessed the putative use of circulating microvesicles (MVs), as innovative biomarkers of radiation toxicity in a cohort of 208 patients with prostate adenocarcinoma overexposed to radiation. The level of platelet (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b3d301d09d928519af7beec5f17af9
https://doi.org/10.21203/rs.3.rs-1733631/v1
https://doi.org/10.21203/rs.3.rs-1733631/v1
Autor:
Chen, Hongjie, Fan, Shaoqi, Stone, Jennifer, Thompson, Deborah J, Douglas, Julie, Li, Shuai, Scott, Christopher, Bolla, Manjeet K, Wang, Qin, Dennis, Joseph, Michailidou, Kyriaki, Li, Christopher, Peters, Ulrike, Hopper, John L, Southey, Melissa C, Nguyen-Dumont, Tu, Nguyen, Tuong L, Fasching, Peter A, Behrens, Annika, Cadby, Gemma, Murphy, Rachel A, Aronson, Kristan, Howell, Anthony, Astley, Susan, Couch, Fergus, Olson, Janet, Milne, Roger L, Giles, Graham G, Haiman, Christopher A, Maskarinec, Gertraud, Winham, Stacey, John, Esther M, Kurian, Allison, Eliassen, Heather, Andrulis, Irene, Evans, D Gareth, Newman, William G, Hall, Per, Czene, Kamila, Swerdlow, Anthony, Jones, Michael, Pollan, Marina, Fernandez-Navarro, Pablo, McConnell, Daniel S, Kristensen, Vessela N, NBCS Investigators, Rothstein, Joseph H, Wang, Pei, Habel, Laurel A, Sieh, Weiva, Dunning, Alison M, Pharoah, Paul, Easton, Douglas F, Gierach, Gretchen L, Tamimi, Rulla M, Vachon, Celine M, Lindström, Sara
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Chen, H, Fan, S, Stone, J, Thompson, D J, Douglas, J, Li, S, Scott, C, Bolla, M K, Wang, Q, Dennis, J, Michailidou, K, Li, C, Peters, U, Hopper, J L, Southey, M C, Nguyen-dumont, T, Nguyen, T L, Fasching, P A, Behrens, A, Cadby, G, Murphy, R A, Aronson, K, Howell, A, Astley, S, Couch, F, Olson, J, Milne, R L, Giles, G G, Haiman, C A, Maskarinec, G, Winham, S, John, E M, Kurian, A, Eliassen, H, Andrulis, I, Evans, D G, Newman, W G, Hall, P, Czene, K, Swerdlow, A, Jones, M, Pollan, M, Fernandez-navarro, P, Mcconnell, D S, Kristensen, V N, Rothstein, J H, Wang, P, Habel, L A, Sieh, W, Dunning, A M, Pharoah, P D P, Easton, D F, Gierach, G L, Tamimi, R M, Vachon, C M & Lindström, S 2022, ' Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci ', Breast Cancer Research, vol. 24, no. 1 . https://doi.org/10.1186/s13058-022-01524-0
Instituto de Salud Carlos III (ISCIII)
Chen, H, Fan, S, Stone, J, Thompson, D J, Douglas, J, Li, S, Scott, C, Bolla, M K, Wang, Q, Dennis, J, Michailidou, K, Li, C, Peters, U, Hopper, J L, Southey, M C, Nguyen-dumont, T, Nguyen, T L, Fasching, P A, Behrens, A, Cadby, G, Murphy, R A, Aronson, K, Howell, A, Astley, S, Couch, F, Olson, J, Milne, R L, Giles, G G, Haiman, C A, Maskarinec, G, Winham, S, John, E M, Kurian, A, Eliassen, H, Andrulis, I, Evans, D G, Newman, W G, Hall, P, Czene, K, Swerdlow, A, Jones, M, Pollan, M, Fernandez-navarro, P, Mcconnell, D S, Kristensen, V N, Rothstein, J H, Wang, P, Habel, L A, Sieh, W, Dunning, A M, Pharoah, P D P, Easton, D F, Gierach, G L, Tamimi, R M, Vachon, C M & Lindström, S 2022, ' Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci ', Breast Cancer Research, vol. 24, no. 1 . https://doi.org/10.1186/s13058-022-01524-0
Background: Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4670b79574f09d39343b94248ad70d4
Autor:
Marc J. Gunter, Inger T. Gram, Elisabete Weiderpass, Hilary A. Tindle, Sun-Seog Kweon, Renée T. Fortner, Rudolf Kaaks, Sarah J Lewis, James Yarmolinsky, Stephen B. Gruber, Marije F. Bakker, Li Hsu, Yi Lin, Neil Murphy, Polly A. Newcomb, Konstantinos K. Tsilidis, Noralane M. Lindor, Rosario Tumino, Gianluca Severi, Hermann Brenner, Emmanouil Bouras, Jane C. Figueiredo, Niki Dimou, Richard M. Martin, Bethany Van Guelpen, María-José Sánchez-Pérez
Publikováno v:
Dimou, N L, Yarmolinsky, J, Martin, R M & Lewis, S J 2021, ' Causal effects of lifetime smoking on breast and colorectal cancer risk : Mendelian randomization study ', Cancer Epidemiology, Biomarkers and Prevention, vol. 30, no. 5, pp. 953-964 . https://doi.org/10.1158/1055-9965.EPI-20-1218
Cancer Epidemiology, Biomarkers and Prevention
Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research, 2021, 30 (5), pp.953-964. ⟨10.1158/1055-9965.EPI-20-1218⟩
Cancer Epidemiol Biomarkers Prev
Cancer Epidemiology, Biomarkers and Prevention
Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research, 2021, 30 (5), pp.953-964. ⟨10.1158/1055-9965.EPI-20-1218⟩
Cancer Epidemiol Biomarkers Prev
Background: Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between smoking and risks of breast and colorectal cancer. Methods: Genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d325bb64bd0798de1e121efc54c17f94
https://research-information.bris.ac.uk/ws/files/270309151/MR_smoking_R3.pdf
https://research-information.bris.ac.uk/ws/files/270309151/MR_smoking_R3.pdf
Publikováno v:
Gut
Gut, 2018, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
Gut, In press, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
Gut, BMJ Publishing Group, In press, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
Gut, 2018, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
Gut, In press, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
Gut, BMJ Publishing Group, In press, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
Over the past two decades a growing body of evidence has demonstrated an important role of tight junction (TJ) proteins in the physiology and disease biology of gastrointestinal (GI) and liver disease. On one side, TJ proteins exert their functional