Zobrazeno 1 - 10
of 1 477
pro vyhledávání: '"NIGRA PARS COMPACTA"'
Publikováno v:
Fundamental Research, Vol 4, Iss 4, Pp 806-819 (2024)
In addition to the cardinal motor symptoms, pain is a major non-motor symptom of Parkinson's disease (PD). Neuroinflammation in the substantia nigra pars compacta and dorsal striatum is involved in neurodegeneration in PD. But the polarization of mic
Externí odkaz:
https://doaj.org/article/2ad383ffc61f4b5a90eb48541f11eb9d
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2057-2076 (2024)
Parkinson's disease (PD) is a neurodegeneration disease with α-synuclein accumulated in the substantia nigra pars compacta (SNpc) and most of the dopaminergic neurons are lost in SNpc while patients are diagnosed with PD. Exploring the pathology at
Externí odkaz:
https://doaj.org/article/1dc15eb260194a128499573398bd7bf5
Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival
Publikováno v:
eLife, Vol 12 (2024)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease (PD). However, whether LRRK2 mutations cause PD and degeneration of dopaminergic (DA) neurons via a toxic gain-of-function or a loss-of-funct
Externí odkaz:
https://doaj.org/article/fabed0c9954044a7be4f1170eeaaa540
Autor:
Bianca Vlcek, Sylvie Dumas, Sara Ekmark-Lewén, Eleonora Rubino, Martin Ingelsson, Åsa Wallén-Mackenzie
Publikováno v:
Exploration of Neuroprotective Therapy, Vol 3, Iss 5, Pp 299-327 (2023)
Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)]. The correlation between αSyn pathology and dopamine neuron degeneration remains to be ful
Externí odkaz:
https://doaj.org/article/63b8257196c94393814fe8426fe8ee40
Autor:
Valentina Basso, Máté D. Döbrössy, Lachlan H. Thompson, Deniz Kirik, Heidi R. Fuller, Monte A. Gates
Publikováno v:
Biology, Vol 13, Iss 9, p 690 (2024)
Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain. While both groups of dopaminergic neurons are in close proximity in the midbrai
Externí odkaz:
https://doaj.org/article/46e30ec8a01f413097654b80e2f27a08
Akademický článek
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Akademický článek
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Autor:
Virginie J. Oberto, Jumpei Matsumoto, Marco N. Pompili, Ralitsa Todorova, Francesco Papaleo, Hisao Nishijo, Laurent Venance, Marie Vandecasteele, Sidney I. Wiener
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionDopamine release in the forebrain by midbrain ventral tegmental nucleus (VTA) and substantia nigra pars compacta (SNc) neurons is implicated in reward processing, goal-directed learning, and decision-making. Rhythmic oscillations of neura
Externí odkaz:
https://doaj.org/article/7d42b2fbdd50431585f506e06b663450
Autor:
Xiaoyu Liu, Hao Zhang, Chuanfen Li, Zhibin Chen, Qian Gao, Muxuan Han, Feng Zhao, Dan Chen, Qiuyue Chen, Minghui Hu, Zifa Li, Sheng Wei, Xiwen Geng
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e16921- (2023)
Background: Curcumin is a natural compound with extensive pharmacological effects. This research is to verify the optimal dose and administration duration efficacy of curcumin in alleviating the movement symptoms of Parkinson's disease (PD). Methods:
Externí odkaz:
https://doaj.org/article/607e6831cc5d47a0ac6ec5e1cd08eb33
Autor:
Mojtaba Jokar, Zhijia Jin, Pei Huang, Ying Wang, Youmin Zhang, Yan Li, Zenghui Cheng, Yu Liu, Rongbiao Tang, Xiaofeng Shi, Jihua Min, Fangtao Liu, Shengdi Chen, Naying He, E. Mark Haacke, Fuhua Yan
Publikováno v:
NeuroImage, Vol 266, Iss , Pp 119814- (2023)
Background and purpose: Early diagnosis of Parkinson's disease (PD) is still a clinical challenge. Most previous studies using manual or semi-automated methods for segmenting the substantia nigra (SN) are time-consuming and, despite raters being well
Externí odkaz:
https://doaj.org/article/7d4603e2a25840e2b545b15937f1de3f