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Akademický článek

Histological evaluation of the possible role of Na+/ H+ entiporter and anion exchanger in endochondral ossification activities of secondary bone healing in rats

Autor: Sahar Ibrahim, Thana’a M Ibrahim, Kareem Handool, Abubakar Abdul, jalila abu, Sabri Yusof, Mehdi Ibrahimmi, Loqman Yusof

Publikováno v: Iraqi Journal of Veterinary Sciences, Vol 34, Iss 2, Pp 233-240 (2020)

In secondary fracture healing, callus proliferate, undergo hypertrophy and the extracellular matrix becomes calcified. This step to some extent, recapitulates the embryological bone development with a combination of cellular proliferation and differe

Externí odkaz: https://doaj.org/article/11c0233a508c47f09115dec3dce0dc3b

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Akademický článek

Guanidine Derivatives of Quinazoline-2,4(1H,3H)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents

Autor: Alexander Spasov, Alexander Ozerov, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Alexander Borisov, Elena Sokolova, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Nadezhda Ovsyankina, Alexey Smirnov, Yulia Velikorodnaya

Publikováno v: Life, Vol 12, Iss 10, p 1647 (2022)

Quinazolines are a rich source of bioactive compounds. Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for a series of quinazoline-2,4(1H,3H)-diones and quinazoline-4(

Externí odkaz: https://doaj.org/article/6046407ded4c4c97915720eb3c4bddcd

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Increased NHE1 expression is targeted by specific inhibitor cariporide to sensitize resistant breast cancer cells to doxorubicin in vitro and in vivo

Autor: Qi Chen, Yueqin Liu, Xiao-lan Zhu, Fan Feng, Hui Yang, Wenlin Xu

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)

Abstract Background The Na+/H+ exchanger (NHE1) plays a crucial role in cancer cell proliferation and metastasis. However, the mechanism underlying chemotherapeutic resistance in cancer cells has not been completely elucidated. The NHE1 inhibitor car

Externí odkaz: https://doaj.org/article/25c02605b7a04444815043d2f3c10c20

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Akademický článek

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Akademický článek

High Glucose Concentration Stimulates NHE-1 Activity in Distal Nephron Cells: the Role of the Mek/Erk1/2/p90RSK and p38MAPK Signaling Pathways

Autor: Juliana Martins da Costa-Pessoa, Rosélia Santos Damasceno, Ubiratan Fabres Machado, Olívia Beloto-Silva, Maria Oliveira-Souza

Publikováno v: Cellular Physiology and Biochemistry, Vol 33, Iss 2, Pp 333-343 (2014)

Aims: In models of diabetes, distal nephron cells contribute to glucose uptake and oxidation. How these cells contribute to the use of glucose for the regulation of H+ extrusion remains unknown. We used Madin-Darby Canine Kidney (MDCK) cells to inves

Externí odkaz: https://doaj.org/article/15fad43d355a4f479696c1f9bd3b3de3

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