Zobrazeno 1 - 10
of 119
pro vyhledávání: '"NH Hendrikse"'
Publikováno v:
Vaalburg, W, Hendrikse, N H, Elsinga, P H, Bart, J & Van Waarde, A 2005, ' P-glycoprotein activity and biological response ', Toxicology and Applied Pharmacology, vol. 207, no. 2 SUPPL. https://doi.org/10.1016/j.taap.2005.03.027
Toxicology and Applied Pharmacology, 207(2 Suppl), 257-60. ACADEMIC PRESS INC ELSEVIER SCIENCE
Toxicology and Applied Pharmacology, 207(2 SUPPL.). Academic Press Inc.
Toxicology and Applied Pharmacology, 207(2 Suppl), 257-60. ACADEMIC PRESS INC ELSEVIER SCIENCE
Toxicology and Applied Pharmacology, 207(2 SUPPL.). Academic Press Inc.
P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most likely P-gp protects organs against endogenous and exogenous toxins by extruding toxic compounds such as chemotherapeutics and other drugs. Many drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e856252ac587f3d3590aa87c68a401f3
https://doi.org/10.1016/j.taap.2005.03.027
https://doi.org/10.1016/j.taap.2005.03.027
Autor:
Dirk Sleijfer, Willem Vaalburg, NH Hendrikse, Harry J.M. Groen, Joost Bart, E. G. E. de Vries, Harry Hollema, T Wegman, W.T.A. van der Graaf
Publikováno v:
European Journal of Cancer, 40(14), 2064-2070. ELSEVIER SCI LTD
Bart, J, Hollema, H, Groen, H J M, De Vries, E G E, Hendrikse, N H, Sleijfer, D T, Wegman, T D, Vaalburg, W & Van Der Graaf, W T A 2004, ' The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours ', European Journal of Cancer, vol. 40, no. 14, pp. 2064-2070 . https://doi.org/10.1016/j.ejca.2004.05.010
European Journal of Cancer, 40(14), 2064-2070. Pergamon
Bart, J, Hollema, H, Groen, H J M, De Vries, E G E, Hendrikse, N H, Sleijfer, D T, Wegman, T D, Vaalburg, W & Van Der Graaf, W T A 2004, ' The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours ', European Journal of Cancer, vol. 40, no. 14, pp. 2064-2070 . https://doi.org/10.1016/j.ejca.2004.05.010
European Journal of Cancer, 40(14), 2064-2070. Pergamon
The drug-efflux pumps P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are present in the blood-testis barrier (BTB) and may hamper the delivery of cytotoxic drugs to the testis. The precise localisation of P-gp and MRP1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea4ed474c5a6c8b714bb3879523853e
https://hdl.handle.net/11370/398d70ff-ddd4-40a6-952c-f94c00bfcc58
https://hdl.handle.net/11370/398d70ff-ddd4-40a6-952c-f94c00bfcc58
Autor:
NH Hendrikse
Publikováno v:
Hendrikse, N H 2000, ' Monitoring interactions at ATP-dependent drug efflux pumps ', Current Pharmaceutical Design, vol. 6, no. 16, pp. 1653-1668 . https://doi.org/10.2174/1381612003398834
Chemotherapeutic treatment of cancer patients is often unsuccessful, due to the involvement of various mechanisms, leading to multidrug resistance (MDR). In this review, I describe the mechanisms involved in MDR. Furthermore, results obtained by imag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287084298d66af34cd1a7cff9b74ec7d
https://doi.org/10.2174/1381612003398834
https://doi.org/10.2174/1381612003398834
Publikováno v:
SYNAPSE, 36(1), 66-74. Wiley-Liss Inc.
Doze, P, Van Waarde, A, Elsinga, P H, Hendrikse, N H & Vaalburg, W 2000, ' Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier ', SYNAPSE, vol. 36, no. 1, pp. 66-74 . https://doi.org/10.1002/(SICI)1098-2396(200004)36:1<66::AID-SYN7>3.0.CO;2-J
Synapse, 36(1), 66-74. WILEY-LISS
Doze, P, Van Waarde, A, Elsinga, P H, Hendrikse, N H & Vaalburg, W 2000, ' Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier ', SYNAPSE, vol. 36, no. 1, pp. 66-74 . https://doi.org/10.1002/(SICI)1098-2396(200004)36:1<66::AID-SYN7>3.0.CO;2-J
Synapse, 36(1), 66-74. WILEY-LISS
Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the β-adrenergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5852484b90ee6da5467375c39271f0e
https://hdl.handle.net/11370/42f0e76b-2ad7-4aad-bdb4-da4506a969a1
https://hdl.handle.net/11370/42f0e76b-2ad7-4aad-bdb4-da4506a969a1
Autor:
W.T.A. van der Graaf, Willem Vaalburg, E. G. E. de Vries, NH Hendrikse, E. Fluks, Alfred H. Schinkel, Antonius Willemsen, Eric J. F. Franssen
Publikováno v:
British Journal of Pharmacology. 124:1413-1418
1. Homozygously mdr1a gene disrupted mice (mdr1a(-/-) mice) and wild type mice (mdr1a(+/+) mice) were used to develop a method for P-glycoprotein (P-gp) function imaging non-invasively and to study the effect of a P-gp reversal agent on its function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::268506284c43e20eaa6b2f1ce688559b
https://doi.org/10.1038/sj.bjp.0701979
https://doi.org/10.1038/sj.bjp.0701979
Enzymatic synthesis of [4-methoxy-11C]daunorubicin for functional imaging of P-glycoprotein with PET
Publikováno v:
Eriks-Fluks, E, Elsinga, P H, Hendrikse, N H, Franssen, E J F & Vaalburg, W 1998, ' Enzymatic synthesis of [4-methoxy-11 C]daunorubicin for functional imaging of P-glycoprotein with PET ', Applied Radiation and Isotopes, vol. 49, no. 7, pp. 811-813 . https://doi.org/10.1016/S0969-8043(97)00302-3
Applied Radiation and Isotopes, 49(7), 811-813. Elsevier Limited
Applied Radiation and Isotopes, 49(7), 811-813. Elsevier Limited
One of the mechanisms for multidrug resistance (MDR) of tumors is an overexpression of the P-glycoprotein (P-gp). The cytostatic agent daunorubicin was labeled with carbon-11 to probe P-gp with PET. An enzymatic route for the conversion of carminomyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85308236882ccb697804830a65f36e9e
https://doi.org/10.1016/s0969-8043(97)00302-3
https://doi.org/10.1016/s0969-8043(97)00302-3
Autor:
NH Hendrikse, Willem Vaalburg
Publikováno v:
Methods, 27(3):PII S1046-2023(02)00079-8, 228-233. ACADEMIC PRESS INC ELSEVIER SCIENCE
Methods, 27(3), 228-233. Academic Press Inc.
Hendrikse, N H & Vaalburg, W 2002, ' Dynamics of multidrug resistance : P-glycoprotein analyses with positron emission tomography ', Methods, vol. 27, no. 3, pp. 228-233 . https://doi.org/10.1016/S1046-2023(02)00079-8
Methods, 27(3), 228-233. Academic Press Inc.
Hendrikse, N H & Vaalburg, W 2002, ' Dynamics of multidrug resistance : P-glycoprotein analyses with positron emission tomography ', Methods, vol. 27, no. 3, pp. 228-233 . https://doi.org/10.1016/S1046-2023(02)00079-8
Multidrug resistance (MDR) is characterized by the occurrence of cross-resistance to a broad range of structurally and functionally unrelated drugs. Several mechanisms are involved in MDR. One of the most well-known mechanisms is the overexpression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45d0e8c74e4d3ee44ca53bf961fab08
https://research.rug.nl/en/publications/7e2e46c0-b47f-48eb-8f6e-3a6d3ebf0e22
https://research.rug.nl/en/publications/7e2e46c0-b47f-48eb-8f6e-3a6d3ebf0e22
Publikováno v:
Hendrikse, N H, De Vries, E G E, Franssen, E J F, Vaalburg, W & Van Der Graaf, W T A 2001, ' In vivo measurement of [ 11 C]verapamil kinetics in human tissues ', European Journal of Clinical Pharmacology, vol. 56, no. 11, pp. 827-829 . https://doi.org/10.1007/s002280000253
European Journal of Clinical Pharmacology, 56(11), 827-829. Springer Verlag
European Journal of Clinical Pharmacology, 56(11), 827-829. Springer Verlag
Objectiva: To evaluate [11C]verapamil kinetics in humans. Methods: After intravenous injection of [11C]verapamil (370 MBq, specific activity >1600 GBq/mmol), kinetics were evaluated in five cancer patients using positron emission tomography (PET). Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592522683b6b21001fde15f6c8896b65
https://research.vumc.nl/en/publications/fa23fc55-d47c-451f-ad31-032057bf123e
https://research.vumc.nl/en/publications/fa23fc55-d47c-451f-ad31-032057bf123e
Autor:
Willem Vaalburg, Joost Bart, Harry J.M. Groen, NH Hendrikse, E. G. E. de Vries, W.T.A. van der Graaf
Publikováno v:
The Journal of Clinical Pharmacology. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51ee1da124d3d6728f675bef4a3f130
https://doi.org/10.1177/0091270001417008
https://doi.org/10.1177/0091270001417008
Autor:
E.G.E. de Vries, W.T.A. van der Graaf, NH Hendrikse, Joost Bart, W Vaalburg, Harry J.M. Groen
Publikováno v:
Bart, J, Groen, H J M, Hendrikse, N H, Van der Graaf, W T A, Vaalburg, W & De Vries, E G E 2000, ' The blood-brain barrier and oncology : New insights into function and modulation ', Cancer Treatment Reviews, vol. 26, no. 6, pp. 449-462 . https://doi.org/10.1053/ctrv.2000.0194
The efficacy of chemotherapy for malignant primary or metastatic brain tumours is still poor. This is at least partly due to the presence of the blood-brain barrier (BBB). The functionality of the BBB can be explained by physicochemical features and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7d4245bca5d07c60ed95ef16dbe551
https://research.vumc.nl/en/publications/c746b261-1d32-44b5-a29e-f7f676fbce49
https://research.vumc.nl/en/publications/c746b261-1d32-44b5-a29e-f7f676fbce49