CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

Autor: Eric Deneault, Muhammad Faheem, Sean H White, Deivid C Rodrigues, Song Sun, Wei Wei, Alina Piekna, Tadeo Thompson, Jennifer L Howe, Leon Chalil, Vickie Kwan, Susan Walker, Peter Pasceri, Frederick P Roth, Ryan KC Yuen, Karun K Singh, James Ellis, Stephen W Scherer

Publikováno v: eLife, Vol 8 (2019)

Induced pluripotent stem cell (iPSC)-derived neurons are increasingly used to model Autism Spectrum Disorder (ASD), which is clinically and genetically heterogeneous. To study the complex relationship of penetrant and weaker polygenic risk variants t

Externí odkaz: https://doaj.org/article/985021e3ed064ed49d8ce14418bde9a2

CNTN5 ^{- /+} or EHMT2 ^{- /+} human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks.

Autor: Deneault E; Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada., Faheem M; Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada., White SH; Department of Biochemistry and Biomedical Sciences, Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Canada., Rodrigues DC; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada., Sun S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; The Donnelly Centre, University of Toronto, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Wei W; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada., Piekna A; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada., Thompson T; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada., Howe JL; Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada., Chalil L; Department of Biochemistry and Biomedical Sciences, Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Canada., Kwan V; Department of Biochemistry and Biomedical Sciences, Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Canada., Walker S; Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada., Pasceri P; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada., Roth FP; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; The Donnelly Centre, University of Toronto, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.; Department of Computer Science, University of Toronto, Toronto, Canada.; Canadian Institute for Advanced Research (CIFAR), Toronto, Canada., Yuen RK; Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada., Singh KK; Department of Biochemistry and Biomedical Sciences, Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Canada., Ellis J; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Scherer SW; Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.; McLaughlin Centre, University of Toronto, Toronto, Canada.

Publikováno v: ELife [Elife] 2019 Feb 12; Vol. 8. Date of Electronic Publication: 2019 Feb 12.