Zobrazeno 1 - 10
of 201
pro vyhledávání: '"NGF, nerve growth factor"'
Autor:
Raquel Comaposada-Baró, Andrea Benito-Martínez, Juan Julian Escribano-Saiz, María Luisa Franco, Lorenzo Ceccarelli, Isabel Calatayud-Baselga, Helena Mira, Marçal Vilar
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Degeneration of basal forebrain cholinergic neurons (BFCNs) is a hallmark of Alzheimer’s disease (AD). However, few mouse models of AD recapitulate the neurodegeneration of the cholinergic system. The p75 neurotrophin receptor, p75NTR, has been ass
Externí odkaz:
https://doaj.org/article/b32bcd3bb77444a1a7f76966aae5d7b9
Autor:
Laura Calvo-Enrique, Silvia Lisa, Cristina Vicente-García, Ruben Deogracias, Juan Carlos Arévalo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting T
Externí odkaz:
https://doaj.org/article/9b53756f987f4e33894ee4bf6cdd45a2
Autor:
Lucia Lisi, Silvia Marinelli, Gabriella Maria Pia Ciotti, Michela Pizzoferrato, Federica Palmerio, Marta Chiavari, Antonino Cattaneo, Pierluigi Navarra
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Previous studies in the rat suggest that microglial cells represent a potential druggable target for nerve growth factor (NGF) in the brain. The painless human Nerve Growth Factor (hNGFp) is a recombinant mutated form of human nerve growth factor (hN
Externí odkaz:
https://doaj.org/article/18285719240c4a3abc90da90ac65571c
Publikováno v:
Frontiers in Materials, Vol 8 (2021)
Peripheral nerve injury is an important cause of disability, that can hinder significantly sensory and motor function. The clinical gold standard for peripheral nerve repair is the use of autografts, nevertheless, this method has limitations such as
Externí odkaz:
https://doaj.org/article/3d211ff82a6945d4a9fb43701eb7e016
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Externí odkaz:
https://doaj.org/article/57e55a59cca74ea1844cc5e2d00d950f
Autor:
Li Zhang, Mingchao Li, Xiaochen Li, Taiyang Liao, Zhenyuan Ma, Runlin Xing, Peimin Wang, Jun Mao
Publikováno v:
Journal of Advanced Research, Vol 35, Iss, Pp 141-151 (2022)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • Synovial fibrosis was positively correlated with pain sensitivity in KOA rats. • Synovial fibrosis was most prominent in DMM group 14 days after modeling. • ACLT replaced DMM to be the most typical at 28 day
Highlights • Synovial fibrosis was positively correlated with pain sensitivity in KOA rats. • Synovial fibrosis was most prominent in DMM group 14 days after modeling. • ACLT replaced DMM to be the most typical at 28 day
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1767-1788 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical events in the damaged areas of the brain, where the ischemic cascade
Autor:
Goshi Shiota, Hiroyuki Tsuchiya
Publikováno v:
Tsuchiya, Hiroyuki. Shiota, Goshi. Immune evasion by cancer stem cells. Regenerative Therapy. 17. 20-33. doi:10.1016/j.reth.2021.02.006
Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021)
Regenerative Therapy
Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021)
Regenerative Therapy
Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have successfully improved outcomes in several tumor types. In addition, currently, immune cell-based therapy is also attracting significant attention. However, t
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the neurotrophic receptor tyrosine kinase 1, 2 and 3 (NTRK1, NTRK2 and NTRK3) genes,
Autor:
Doriano Lamba, Sonia Covaceuszach, Franci Merzel, Alberto Cassetta, Francesca Paoletti, Simona Golic Grdadolnik, Iza Ogris, Jože Grdadolnik
Publikováno v:
Computational and Structural Biotechnology Journal 19 (2021): 2938–2949. doi:10.1016/j.csbj.2021.05.009
info:cnr-pdr/source/autori:Paoletti F.; Merzel F.; Cassetta A.; Ogris I.; Covaceuszach S.; Grdadolnik J.; Lamba D.; Golic Grdadolnik S./titolo:Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions/doi:10.1016%2Fj.csbj.2021.05.009/rivista:Computational and Structural Biotechnology Journal/anno:2021/pagina_da:2938/pagina_a:2949/intervallo_pagine:2938–2949/volume:19
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2938-2949 (2021)
Computational and Structural Biotechnology Journal
info:cnr-pdr/source/autori:Paoletti F.; Merzel F.; Cassetta A.; Ogris I.; Covaceuszach S.; Grdadolnik J.; Lamba D.; Golic Grdadolnik S./titolo:Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions/doi:10.1016%2Fj.csbj.2021.05.009/rivista:Computational and Structural Biotechnology Journal/anno:2021/pagina_da:2938/pagina_a:2949/intervallo_pagine:2938–2949/volume:19
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2938-2949 (2021)
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • High-resolution solution NMR structure of rhNGF has been determined. • Quinary interactions characterize ATP binding to rhNGF. • SPR, ITC and STD-NMR reveal ATP binding to rhNGF with mM affinity. • NMR and
Highlights • High-resolution solution NMR structure of rhNGF has been determined. • Quinary interactions characterize ATP binding to rhNGF. • SPR, ITC and STD-NMR reveal ATP binding to rhNGF with mM affinity. • NMR and