Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

Autor: Xu Shen, Xiaoxia Qiu, Jiaying Wang, Wenwen Liu, Xiaokang Li, Fei Mao, Jian Lu, Baoli Li, Jin Zhu, Yixiang Xu, Jian Li, Lei Fan

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 646-666 (2020)

Drug repurposing is an efficient strategy for new drug discovery. Our latest study found that nitazoxanide (NTZ), an approved anti-parasite drug, was an autophagy activator and could alleviate the symptom of Alzheimer's disease (AD). In order to furt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe46f557fb401b09743b51fe8f97388
https://doi.org/10.1016/j.apsb.2019.07.006

Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in

Autor: Yaqi, Bian, Yan, Chen, Xiufen, Wang, Guozhen, Cui, Carolina Oi Lam, Ung, Jia-Hong, Lu, Weihong, Cong, Benqin, Tang, Simon Ming-Yuen, Lee

Publikováno v: Journal of Advanced Research

Graphical abstract
Introduction Alzheimer’s disease (AD) is a progressive brain disorder, and one of the most common causes of dementia and amnesia. Due to the complex pathogenesis of AD, the underlying mechanisms remain unclear. Although scie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3090862335a7f32f524024221c5d9745
https://pubmed.ncbi.nlm.nih.gov/35024177

Impaired burrowing is the most prominent behavioral deficit of aging htau mice

Autor: Geiszler, Philippine Camilla, Barron, Matthew Richard, Pardon, Marie-Christine

Publikováno v: Neuroscience

Highlights • htau mice exhibit robust deficits in food burrowing. • Behavioral differences between htau and mtau−/− are age-dependent. • Before 6 months of age, the htau phenotype is stronger than the mtau−/− phenotype. • With aging,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::61310e056bfb5481f2b1c4b154f231f2
http://europepmc.org/articles/PMC4915442

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

Autor: Ettcheto Arriola, Miren, Sánchez-López, E. (Elena), Pons, Laura, Busquets Figueras, Oriol, Olloquequi González, Jordi, Beas Zárate, Carlos, Pallàs i Llibería, Mercè, 1964, García López, María Luisa, Auladell i Costa, M. Carme, Folch, Jaume, Camins Espuny, Antoni

Publikováno v: Redox Biology, Vol 13, Iss C, Pp 345-352 (2017)
Redox Biology
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

The aim of the present study is to elucidate the neuronal pathways associated to NSAIDs causing a reduction of the risk and progression of Alzheimer's disease. The research was developed administering the active enantiomer of ibuprofen, dexibuprofen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eeb03ed861896c8e278a922a0d33b70d
http://hdl.handle.net/2445/118847

Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies

Autor: Lethbridge, Natasha L., Chazot, Paul L.

Publikováno v: Pharmacological Research

Graphical abstract
Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f69fd402bc4bd08498b8423c665ea2a