Zobrazeno 1 - 10
of 19
pro vyhledávání: '"NFT, neurofibrillary tangle"'
Publikováno v:
EBioMedicine
EBioMedicine, Vol 74, Iss, Pp 103691-(2021)
EBioMedicine, Vol 74, Iss, Pp 103691-(2021)
Alzheimer's disease (AD) represents a particular therapeutic challenge because its aetiology is very complex, with dynamic progression from preclinical to clinical stages. Several potential therapeutic targets and strategies were tested for AD, in ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29cce4e1140f2066726bcb229d5e3c7
http://europepmc.org/articles/PMC8602003
http://europepmc.org/articles/PMC8602003
Autor:
Lindsay A. Welikovitch, A. Claudio Cuello, Sonia Do Carmo, Hélène Hall, Lionel Breuillaud, Jennifer A. Macdonald, Janice C. Malcolm, Michel Goedert
Publikováno v:
Neurobiology of Disease
Neurobiology of Disease, Vol 127, Iss, Pp 323-338 (2019)
Neurobiology of Disease, Vol 127, Iss, Pp 323-338 (2019)
The assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c356ee287988d903aead7862cea5f6
https://doi.org/10.1016/j.nbd.2019.03.018
https://doi.org/10.1016/j.nbd.2019.03.018
Publikováno v:
The Journal of Biological Chemistry
Familial British dementia and familial Danish dementia are neurodegenerative disorders caused by mutations in the gene integral membrane protein 2B (ITM2b) encoding BRI2, which tunes excitatory synaptic transmission at both presynaptic and postsynapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e551c51b462662a8e05481a6c8b948
https://pubmed.ncbi.nlm.nih.gov/34416235
https://pubmed.ncbi.nlm.nih.gov/34416235
Autor:
Mircea Balasa, Jaume Olives, Albert Lladó, José Contador, Neus Falgàs, Sergi Borrego-Écija, Anna Antonell, Agnés Pérez‐Millan, Guadalupe Fernández-Villullas, Alzheimer’s Disease Neuroimaging Initiative, Magdalena Castellví, Adrià Tort-Merino, Raquel Sánchez-Valle, Núria Bargalló, Roser Sala-Llonch, Oscar Ramos-Campoy, Beatriz Bosch
Publikováno v:
NeuroImage: Clinical, Vol 32, Iss, Pp 102804-(2021)
NeuroImage : Clinical
NeuroImage : Clinical
Highlights • Posterior cortices, hippocampus and amygdala track atrophy in EOAD over two years. • The medial temporal cortex is unaltered in EOAD at early stages. • EOAD exhibited a posterior-to-anterior gradient of cortical loss after two year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45da3c071893e79add0f05ad6e3dad97
http://www.sciencedirect.com/science/article/pii/S2213158221002485
http://www.sciencedirect.com/science/article/pii/S2213158221002485
Autor:
Measho Abreha, Allan I. Levey, Shamsideen A. Ojelade, Duc M. Duong, Zachary T. McEachin, Gary J. Bassell, Eric B. Dammer, Nicholas T. Seyfried, James J. Lah, Joshua M. Shulman, Marla Gearing
Publikováno v:
The Journal of Biological Chemistry
One of the defining pathological features of Alzheimer’s Disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD has been suggested to enhance phosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f79bdc687578d84246e18e1f234fa5
https://doi.org/10.1101/2020.06.17.157552
https://doi.org/10.1101/2020.06.17.157552
Autor:
Mark L. Cohen, Sofie Nyström, He Liu, Jiri G. Safar, Christina J. Sigurdson, Per Hammarström, Thomas Wisniewski, K. Peter R. Nilsson, Tracy Haldiman, Chae Kim
Publikováno v:
The Journal of Biological Chemistry
Amyloid beta (A beta) deposition in the neocortex is a major hallmark of Alzheimers disease (AD), but the extent of deposition does not readily explain phenotypic diversity and rate of disease progression. The prion strain-like model of disease heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfcbb82c2fb6f83a2e70093c812eb2c
https://doi.org/10.1016/j.jbc.2021.101267
https://doi.org/10.1016/j.jbc.2021.101267
Autor:
Anita Huttner, Stephen M. Strittmatter, Alison Chase, Charlotte Herber, Sarah Helena Nies, Hideyuki Takahashi
Publikováno v:
The Journal of Biological Chemistry
In Alzheimer's disease (AD), deposition of pathological tau and amyloid-β (Aβ) drive synaptic loss and cognitive decline. The injection of misfolded tau aggregates extracted from human AD brains drives templated spreading of tau pathology within WT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a4ef2dad966a0ccb1a001c52a6c6b9
https://doi.org/10.1016/j.jbc.2021.101159
https://doi.org/10.1016/j.jbc.2021.101159
Autor:
Guglielmi, Alessio
Tau is natively an unfolded protein that promotes the assembly and the stability of the axonal microtubules in the central nervous system. Increased formation of Tau protein aggregates has been causatively implicated in several neurodegenerative dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3507::4f68ffb0bb89701a2fef48e67e94173f
http://repozitorij.ung.si/IzpisGradiva.php?id=4778
http://repozitorij.ung.si/IzpisGradiva.php?id=4778
Autor:
Mashhood Wani, Mary Migliorini, Dudley K. Strickland, Allison L. Arai, Bradley T. Hyman, Aurélien Lathuilière, Simon Dujardin, Selen C. Muratoglu, Joanna M. Cooper
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
Journal of Biological Chemistry, Vol. 296 (2021) P. 100715
The Journal of Biological Chemistry
Journal of Biological Chemistry, Vol. 296 (2021) P. 100715
In Alzheimer's disease (AD), pathological forms of tau are transferred from cell to cell and "seed" aggregation of cytoplasmic tau. Phosphorylation of tau plays a key role in neurodegenerative tauopathies. In addition, apolipoprotein E (apoE), a majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa173b12d79999cc644ce06ed4b509d6
https://doi.org/10.1016/j.jbc.2021.100715
https://doi.org/10.1016/j.jbc.2021.100715
Autor:
Angela Everhart, Carol A. Colton, Donna M. Wilcock, Qun Zhao, Marcia N. Gordon, Jennifer E. Lee, Dave Morgan, Joan G. Wilson
Publikováno v:
ASN NEURO
ASN Neuro, Vol 3 (2011)
ASN Neuro, Vol 3 (2011)
While the presence of an inflammatory response in AD (Alzheimer's disease) is well known, the data on inflammation are conflicting, suggesting that inflammation either attenuates pathology, exacerbates it or has no effect. Our goal was to more fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c9d5e0aee05b524069607d962a18de
https://pubmed.ncbi.nlm.nih.gov/21995345
https://pubmed.ncbi.nlm.nih.gov/21995345