Výsledky vyhledávání - "NF-kappa B/*physiology"

Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene

Autor: John DiGiovanni, Gyu Song, Lars Mecklenburg, Alexsandra Espejo, Richard D. Wood, Jean Louis Guénet, Jean Jaubert, Marcela Del Rio, Donna F. Kusewitt, Claudio J. Conti, Fernando Benavides, Lucía Martínez-Santamaría, Sharon Y.R. Dent, Eleonora Napoli, Cecilia R Giulivi, Carlos J. Perez, Brian M. Iritani, Mark T. Bedford

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2015, 135 (12), pp.3133-3143. ⟨10.1038/jid.2015.314⟩
The Journal of investigative dermatology
The Journal of investigative dermatology, vol 135, iss 12
Journal of Investigative Dermatology, 2015, 135 (12), pp.3133-3143. ⟨10.1038/jid.2015.314⟩

International audience; Here we describe a spontaneous mutation in the Zdhhc13 (zinc finger, DHHC domain containing 13) gene (also called Hip14l), one of 24 genes encoding palmitoyl acyltransferase (PAT) enzymes in the mouse. This mutation (Zdhhc13lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c34a12fdbc04c5b36082aba45daae43
https://doi.org/10.1038/jid.2015.314

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The paracaspase MALT1: biological function and potential for therapeutic inhibition

Autor: Jaworski, M., Thome, M.

Publikováno v: Cellular and Molecular Life Sciences, vol. 73, no. 3, pp. 459-473

The paracaspase MALT1 has a central role in the activation of lymphocytes and other immune cells including myeloid cells, mast cells and NK cells. MALT1 activity is required not only for the immune response, but also for the development of natural Tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::90f9c7e7413dd915e6da11a9c24d9802
https://serval.unil.ch/notice/serval:BIB_B68EA67B0DAA

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The many faces of the copper metabolism protein MURR1/COMMD1

Autor: B van de Sluis, Cisca Wijmenga, P de Bie, L. W. J. Klomp

Publikováno v: Journal of Heredity. 96(7):803-11

Copper is an essential transition metal but is toxic in excess; therefore, its metabolism needs to be tightly regulated. Defects in the regulation of copper can lead to various disorders characterized by copper deficiency or copper excess. Recently,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512a83cfaa4656eeff8005bb0fcc9ff3
https://doi.org/10.1093/jhered/esi110

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The many faces of the copper metabolism protein MURR1/COMMD1

Publikováno v: Journal of Heredity. 96(7):803-811

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::cd39613b1a6efcd35f2e5cc30a19fa9e
https://research.rug.nl/en/publications/5c9ab657-e578-4872-bdf1-666e7871469f

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IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors

Autor: Thierry Fest, Fabien Guilloton, Dirk Hose, Nicolas Robert, Karin Tarte, Maïlys Cren, Karine Bollore, Bernard Klein, Michel Jourdan, Christophe Duperray

Publikováno v: Leukemia
Leukemia, 2014, 28 (8), pp.1647-56. ⟨10.1038/leu.2014.61⟩
Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2014, 28 (8), pp.1647-56. ⟨10.1038/leu.2014.61⟩

International audience; The recent understanding of plasma cell (PC) biology has been obtained mainly from murine models. The current concept is that plasmablasts home to the BM and further differentiate into long-lived PCs (LLPCs). These LLPCs survi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c714dd9f1e6f859cdacbfe5630b51d2d
https://univ-rennes.hal.science/hal-00974531

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Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death

Autor: Mark Peakman, Timothy Tree, Marta Vives-Pi, Colin M. Dayan, Katherine Marks, Piero Marchetti, Jake Powrie, Esteban Nicolas Gurzov, Ricardo Pujol-Borrell, Raquel Planas, Decio L. Eizirik, Guo Cai Huang, Thomas Bouckenooghe, Sefina Arif, Fabrice Moore

Publikováno v: Diabetes
Diabetes (New York, N.Y.), 60 (8

CD4 T-cells secreting interleukin (IL)-17 are implicated in several human autoimmune diseases, but their role in type 1 diabetes has not been defined. To address the relevance of such cells, we examined IL-17 secretion in response to β-cell autoanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33011c2ac8e33c8a8b732fcff352b874
https://pubmed.ncbi.nlm.nih.gov/21659501

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An NF-χB-like element plays an essential role in interleukin-1-mediated costimulation of the mouse interleukin-2 promoter

Autor: Edgar Serfling, Werner Falk, Kirstin Strieker, Peter H. Krammer

Publikováno v: European Journal of Immunology. 23:1475-1480

Interleukin-1 (IL-1) costimulation is required for efficient IL-2 synthesis and IL-2 receptor (IL-2R) expression of T cells. The molecular events leading to these effects are largely unknown. We utilized an IL-1-responsive and an IL-1-non-responsive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787e5dd5889e9f267d52c5d3fe05a7c2
https://doi.org/10.1002/eji.1830230712

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TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL

Autor: Wendy D. Cook, W. Wei-Lynn Wong, James E Vince, Maryline Moulin, Bernard A. Callus, David L. Vaux, Donia M Moujalled, Ian E Gentle, Diep Chau, John Silke, Ulrich Nachbur, Nufail Khan, Josep M. Lluis

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8620 (2010)
PLoS ONE
PLoS One, vol. 5, no. 1, pp. e8620

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known as a "death ligand"-a member of the TNF superfamily that binds to receptors bearing death domains. As well as causing apoptosis of certain types of tumor cells, TRAIL can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71f24436c1e935f52a21ca787dffc7a
http://europepmc.org/articles/PMC2797639?pdf=render

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Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation

Autor: Batsi, C., Markopoulou, S., Kontargiris, E., Charalambous, C., Thomas, C., Christoforidis, S., Kanavaros, P., Constantinou, A. I., Marcu, K. B., Kolettas, E.

2-Methoxyestradiol (2-ME2) induces leukemia cells to undergo apoptosis in association with Bcl-2 inactivation but the mechanisms whereby Bcl-2 contributes to protection against programmed cell death in this context remain unclear. Here we showed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::910d65207ed918752b5803f7d2216cff
http://olympias.lib.uoi.gr/jspui/handle/123456789/23528

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Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation

Autor: Gordon C. Weir, Lorella Marselli, François Pattou, Marianne Böni-Schnetzler, Marc Y. Donath, Julie Kerr-Conte, Philippe A. Halban, Géraldine Parnaud, Jan A. Ehses, Jeffrey Thorne

Publikováno v: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No 10 (2008) pp. 4065-74

Context: Elevated glucose levels impair islet function and survival, and it has been proposed that intraislet expression of IL-1β contributes to glucotoxicity.Objective: The objective was to investigate IL-1β mRNA expression in near-pure β-cells o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43800f510aafa36732a6f497838a7ab1

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