Zobrazeno 1 - 10
of 3 309
pro vyhledávání: '"NF-κb pathway"'
Autor:
Payton De La Cruz, Julia McAdams, Melanie Morales Aquino, Aileen I. Fernandez, Andrew Elliott, Maryam Lustberg, Christoph Schorl, Jennifer R. Ribeiro, Nicole E. James
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-19 (2024)
Abstract Background Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. While PD-1 based immunotherapies overall have led to improved treatment outcomes for this disease, a diverse response to frontline chemotherapy
Externí odkaz:
https://doaj.org/article/d70bfb940b8c4a6e827519886136689e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Glioma is a common and fatal malignant primary brain tumor. Radiotherapy and first-line chemotherapy have little effect on the survival rate of patients, requiring alternative therapies. The main active ingredient of Tripterygium wilfordii H
Externí odkaz:
https://doaj.org/article/2be9702c32284356b44dec350506b2a9
Autor:
Chaogang Wang, Zhuxiang Jiang, Mingyang Du, Rihao Cong, Wei Wang, Taiping Zhang, Jincheng Chen, Guofan Zhang, Li Li
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-27 (2024)
Abstract Phosphorylation of Ser32 and Ser36 controls the degradation of IκBα is the conserved cascade mechanisms of immune core signaling pathway, NF-κB pathway in metazoans, but it’s response to abiotic stress and the presence of novel phosphor
Externí odkaz:
https://doaj.org/article/13492d2b591d473f9b2ef6529780a4d3
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract To evaluate the levels of YKL40, IL-6(interleukin-6), IL-8(interleukin-8), IL-10(interleukin-10), TNF-α (tumor necrosis factor-α) in OSAS (obstructive sleep apnea syndrome)children and explore the mechanism of YKL40 promoting inflammatory
Externí odkaz:
https://doaj.org/article/1190fc0d2eef4d35b6891619815a48e1
Autor:
Xiaowen Huang, Pengju Wei, Cheng Fang, Min Yu, Shilun Yang, Linhui Qiu, Yu Wang, Aimin Xu, Ruby Lai Chong Hoo, Junlei Chang
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract The blood-brain barrier (BBB) is a critical interface that maintains the central nervous system homeostasis by controlling the exchange of substances between the blood and the brain. Disruption of the BBB plays a vital role in the developmen
Externí odkaz:
https://doaj.org/article/b51dc661b9f841bcb71c732f4338d00d
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Background: Histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDAC5) are two isoforms of class IIa HDACs, and LMK235 is an HDAC inhibitor with higher selectivity for HDAC4/5. This study aimed to explore the expression and subcellular
Externí odkaz:
https://doaj.org/article/6cfadd4f34824f219325a01672b312d5
Autor:
Riya Thapa, Ehssan Moglad, Ahsas Goyal, Asif Ahmad Bhat, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Haider Ali, Brian Gregory Oliver, Ronan MacLoughlin, Harish Dureja, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 991-1017 (2024)
One of the main causes of death worldwide is lung cancer, which is largely caused by cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory responses and various cellular processes, is a constitutively present cytopla
Externí odkaz:
https://doaj.org/article/3a63641c2bc8460b81a8e26ddd1b49f8
Publikováno v:
Journal of Men's Health, Vol 20, Iss 8, Pp 63-68 (2024)
Delayed wound healing is one vital complication of diabetes mellitus (DM) that adversely impacts patient quality of life. Infliximab (INF), a monoclonal tumor necrosis factor α (TNF-α) antibody, has been investigated for its therapeutic potential a
Externí odkaz:
https://doaj.org/article/6e8289e579bc458c94a3450a9397b4a4
Autor:
Chao Ma, Yansong Wang
Publikováno v:
Brain Research Bulletin, Vol 220, Iss , Pp 111139- (2025)
Spinal cord injury (SCI) is a devastating disease characterized by neuroinflammation and irreversible neuronal loss. The basic helix-loop-helix family member e40 (Bhlhe40) is a stress-responsive transcription factor involved in the pathological proce
Externí odkaz:
https://doaj.org/article/56d8cd3317e146de8abfd2ac9fb79303
Autor:
Mohsen Ghiasi
Publikováno v:
Heliyon, Vol 10, Iss 23, Pp e40812- (2024)
Heart failure (HF) syndrome is of great interest as an emerging epidemic. Due to the increasing elderly population worldwide, the total number of HF patients is increasing every day. This disease places a significant economic burden on the healthcare
Externí odkaz:
https://doaj.org/article/6ac88640df8946dab94e6ebc2bc18580