Zobrazeno 1 - 10
of 4 266
pro vyhledávání: '"NF-κB signaling"'
Publikováno v:
Journal of Orthopaedic Translation, Vol 48, Iss , Pp 133-145 (2024)
Background: Spinal cord injuries (SCIs) trigger a cascade of detrimental processes, encompassing neuroinflammation and oxidative stress (OS), ultimately leading to neuronal damage. Phillygenin (PHI), isolated from forsythia, is used in a number of bi
Externí odkaz:
https://doaj.org/article/37dfb9e365cd468697cbcac6c239a063
Autor:
Weijun Liu, Qingbo Li, Weizhi Fang, Lei Cai, Zhengkun Wang, Bowen Kou, Chuankun Zhou, Yichi Zhou, Zhi Yao, Mengcheng Wei, Shishuang Zhang
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-13 (2024)
Abstract Background Reduction of inflammatory damage and inhibition of nucleus pulposus (NP) apoptosis are considered to be the main effective therapy idea to reverse the intervertebral disc degeneration (IDD) and alleviate the chronic low back pain.
Externí odkaz:
https://doaj.org/article/7f63f5129fa440318f801144c331588a
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 3871-3889 (2024)
Jingjing Wei,1,* Zhaoyang Liu,1,2,* Mingming Li,1 Lingyun Du,1 Xia Zhu,1 Yi Leng,1 Changyu Han,1 Qingqing Xu,1 Chunhong Zhang1 1Department of Dermato-Venereology, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, P
Externí odkaz:
https://doaj.org/article/96daa4f0f58d4d0cb834e217d4676cc3
Publikováno v:
Shipin gongye ke-ji, Vol 45, Iss 16, Pp 340-347 (2024)
Objective: To investigate the effect and mechanism of Hippophae rhamnoides flavone (HRF) on polycystic ovarian syndrome (PCOS) in rats, and to provide new ideas for the prevention and treatment of PCOS. Methods: A PCOS rat model was duplicated by giv
Externí odkaz:
https://doaj.org/article/5f6eaec194a9434398d23e58bee4909a
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Drug resistance, including Adriamycin-based therapeutic resistance, remains a challenge in breast cancer (BC) treatment. Studies have revealed that macrophages could play a pivotal role in mediating the chemoresistance of cancer c
Externí odkaz:
https://doaj.org/article/4e9516812ea246e8ad3624c26d82d21a
Autor:
Wan-ting Meng, Jing Zhu, Ya-chao Wang, Chang-le Shao, Xiu-ya Li, Ping-ping Lu, Meng-ying Huang, Fang-fang Mou, Hai-dong Guo, Guang Ji
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium. This phenomenon is known as myocardial ischemia-reperfusion injury (
Externí odkaz:
https://doaj.org/article/2e5aa75e60694b41aeeb7d7245ef7886
Autor:
Feng Xiao, Hong Zhu, Yaping Xiong, Yun Guo, Zhe Zhang, Jie Zeng, Yao Xiao, Bin Liao, Xuesong Shang, Siyi Zhao, Guowen Hu, Kai Huang, Hua Guo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)
Abstract Background Recent studies have highlighted the significant role of the NF-κB signaling pathway in the initiation and progression of cancer. Furthermore, long noncoding RNAs (lncRNAs) have been identified as pivotal regulators in sustaining
Externí odkaz:
https://doaj.org/article/c1ff45ab488c4edbb8d397555e56b8fc
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 525-31 (2024)
The study aimed to investigate the effect of CD1d down-regulation on the proliferation, migration, and apoptosis of papillary thyroid carcinoma cells and explore the underlying mechanism. CD1d expression was silenced in TPC-1 cells by transfection of
Externí odkaz:
https://doaj.org/article/323afeac14784a1e843cb58034eaeac5
Autor:
Ran Bi, Dan Zhang, Rui Quan, Xiaoxian Lin, Wen Zhang, Chuangang Li, Man Yuan, Bing Fang, Dongliang Wang, Yixuan Li
Publikováno v:
Food Science & Nutrition, Vol 12, Iss 6, Pp 4196-4210 (2024)
Abstract Exposure to cigarette smoke directly damages the lungs and causes lung inflammation. The anti‐inflammatory properties of edible bird's nest (EBN) have been reported. We aimed to determine the effect of EBN on pneumonia in a mouse model exp
Externí odkaz:
https://doaj.org/article/1d8e108963b24ee38d8996c01f5ed04e
Publikováno v:
Gut and Liver, Vol 18, Iss 3, Pp 414-425 (2024)
Background/Aims: Gastric intestinal metaplasia (GIM), a common precancerous lesion of gastric cancer, can be caused by bile acid reflux. GATA binding protein 4 (GATA4) is an intestinal transcription factor involved in the progression of gastric cance
Externí odkaz:
https://doaj.org/article/fbc52a38dd1240e9b6da82dcddc84b5e