Zobrazeno 1 - 10
of 717
pro vyhledávání: '"NF-κB activation"'
Autor:
Jie Yuan, Bhanuprakash C. Narasimhachar, Akshay Ravish, Li Yang, Hua Zhang, Qun Wang, Zhi Li, Jun Huang, Bei Wang, Geng Wang, Keshav Kumar Harish, Arunachalam Chinnathambi, Chandramohan Govindasamy, Mahendra Madegowda, Basappa Basappa
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionNuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression. We have previously reported oxazine and piperazine-lin
Externí odkaz:
https://doaj.org/article/66c2cc0a7bac4368a394f36398fd78cd
Autor:
Silje Harvei, Vemund Skogen, Bjørg Egelandsdal, Signe Birkeland, Jan Erik Paulsen, Harald Carlsen
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
IntroductionLipopolysaccharides (LPS) present in the intestine are suggested to enter the bloodstream after consumption of high-fat diets and cause systemic inflammation and metabolic dysregulation through a process named “metabolic endotoxemia.”
Externí odkaz:
https://doaj.org/article/e667af9fc2e64a03a61736dc36662933
Autor:
Zeng Junan, Zhao Guangyu
Publikováno v:
Open Medicine, Vol 18, Iss 1, Pp 203-23 (2023)
Sepsis is one of the most fatal inflammatory diseases with multiple organ failure caused by pathological infection. α-Hederin, a monodesmosidic triterpenoid saponin, has many biological activities including anti-inflammation. This study aimed to inv
Externí odkaz:
https://doaj.org/article/b7f34fca1b7a468cb7dd022dc16ce1ae
Akademický článek
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Publikováno v:
Genes and Diseases, Vol 9, Iss 1, Pp 176-186 (2022)
Germline heterozygous gain-of-function (GOF) mutation of NFKBIA, encoding IκBα, would affect the activation of NF-κB pathway and cause an autosomal dominant (AD) form of anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID). Here we repor
Externí odkaz:
https://doaj.org/article/262667ad5aa04a3d9ed31e56350459b6
Autor:
Rui-Chao Chai, Yu-Zhou Chang, Xin Chang, Bo Pang, Song Yuan An, Ke-Nan Zhang, Yuan-Hao Chang, Tao Jiang, Yong-Zhi Wang
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-16 (2021)
Abstract Background The prognosis for diffuse gliomas is very poor and the mechanism underlying their malignant progression remains unclear. Here, we aimed to elucidate the role and mechanism of the RNA N6,2′-O-dimethyladenosine (m6A) reader, YTH N
Externí odkaz:
https://doaj.org/article/2e2649ec68d14cc88e5420d0becd1d92
Autor:
Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang, Li-Yun Gong
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-mRNA splicing and tum
Externí odkaz:
https://doaj.org/article/26b6eb05daf44e0dbb6fe59bd7e9b882
Autor:
Zhuo Luo, Xiu-Ping Kuang, Qing-Qing Zhou, Chang-Yu Yan, Wen Li, Hai-Biao Gong, Hiroshi Kurihara, Wei-Xi Li, Yi-Fang Li, Rong-Rong He
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2323-2338 (2020)
Herpes simplex virus type 1 (HSV-1) is a ubiquitous and widespread human pathogen, which gives rise to a range of diseases, including cold sores, corneal blindness, and encephalitis. Currently, the use of nucleoside analogs, such as acyclovir and pen
Externí odkaz:
https://doaj.org/article/abf265e50b414c178652de769beeb9d8
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Acinetobacter baumannii is a highly pathogenic Gram-negative bacterium that causes severe infections with very high fatality rates. A. baumannii infection triggers innate as well as adaptive immunity, however, our understanding of the inflammatory fa
Externí odkaz:
https://doaj.org/article/698410c372334f9fab9cdca011bb5415
Autor:
Yunfei Wang, Kaikai Yi, Xing Liu, Yanli Tan, Weili Jin, Yansheng Li, Junhu Zhou, Hongjun Wang, Chunsheng Kang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundCheckpoint blockade therapies targeting programmed death ligand 1 (PD-L1) and its receptor programmed cell death 1 promote T cell-mediated immune surveillance against tumors and have been associated with significant clinical benefit in canc
Externí odkaz:
https://doaj.org/article/6e72c5e777a348118a3ce1ca60c55667