Zobrazeno 1 - 8 of 8 pro vyhledávání: '"NEUROSEARCH AS"'
1
SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE
Autor: NEUROSEARCH AS, JESSEN CARSTEN, BROWN WILLIAM DALBY, STROEBAEK DORTE
The present application discloses novel substituted pyridinyl-methylamine derivatives and their use as modulators of the voltage gated Kv7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, in a meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=epopatstat__::ddc5bf32879fcc3246c72bd57f51455f
https://register.epo.org/application?number=EP2010053072
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2
CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
Autor: NEUROSEARCH AS, PETERS DAN, MUNRO GORDON, NIELSEN ELSEBET OESTERGAARD
The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=epopatstat__::94cca208ecfe0a5375a787f564e4f81f
https://register.epo.org/application?number=EP2011060554
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4
Roles of RFRP-3 in the daily and seasonal regulation of reproductive activity in female Syrian hamsters
Autor: Caroline Ancel, Jo B. Henningsen, François Gauer, Valérie Simonneaux, Jens D. Mikkelsen
Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2016, pp.en.2016-1689. ⟨10.1210/en.2016-1689⟩
In females, reproductive activity relies on proper integration of daily and environmental changes as well as cyclic sex-steroid feedback. This study sought to investigate the role of the hypothalamic Arg-Phe amide-related peptide (RFRP)-3 in the dail
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923048e5edff7eed6d382729c112666c
https://doi.org/10.1210/en.2016-1689
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5
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Autor: Rik Vandenberghe, Maria Mattheijssens, Kristel Sleegers, Nathalie Brouwers, Nathalie Le Bastard, Ekaterina Rogaeva, Richard Mayeux, Jean-Charles Lambert, Sebastiaan Engelborghs, Peter St George-Hyslop, Peter Paul De Deyn, Christine Van Broeckhoven, Steven Vermeulen, Karolien Bettens, Philippe Amouyel, Florence Pasquier, Karin Peeters, Jasper Van Dongen
Publikováno v: Molecular neurodegeneration
Molecular Neurodegeneration
Molecular Neurodegeneration, BioMed Central, 2012, 7 (1), pp.3. ⟨10.1186/1750-1326-7-3⟩
Molecular Neurodegeneration, 2012, 7 (1), pp.3. ⟨10.1186/1750-1326-7-3⟩
Molecular Neurodegeneration, Vol 7, Iss 1, p 3 (2012)
Background We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regulatory regions in an extende
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91be1e8ce191e193e2d4cb3dc665e342
https://doi.org/10.1186/1750-1326-7-3
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6
Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters
Autor: Paul Pévet, Michel Saboureau, Jens D. Mikkelsen, Mireille Masson-Pévet, Florent G. Revel, Valérie Simonneaux
Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2006, 16(17), pp.1730-1735
SummaryThe KiSS-1 gene encodes kisspeptin, the endogenous ligand of the G-protein-coupled receptor GPR54 [1–4]. Recent data indicate that the KiSS-1/GPR54 system is critical for the regulation of reproduction and is required for puberty onset [5–
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0838da0fe39449d8e7188d556189c8a8
https://hal.archives-ouvertes.fr/hal-00093418
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7
Melatonin Regulates Type 2 Deiodinase Gene Expression in the Syrian Hamster
Autor: Paul Pévet, Michel Saboureau, Jens D. Mikkelsen, Florent G. Revel, Valérie Simonneaux
Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2006, 147, pp.4680-4687
In seasonal species, photoperiod organizes various physiological processes, including reproduction. Recent data indicate that the expression of type 2 iodothyronine deiodinase (Dio2) is modulated by photoperiod in the mediobasal hypothalamus of some
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23eca6251522576e3240998444e92586
https://hal.archives-ouvertes.fr/hal-00093461
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8
KiSS-1: a likely candidate for the photoperiodic control of reproduction in seasonal breeders
Autor: Jens D. Mikkelsen, Paul Pévet, Mireille Masson-Pévet, Michel Saboureau, Florent G. Revel, Valérie Simonneaux
Publikováno v: Chronobiology International
Chronobiology International, Taylor & Francis, 2006, 23(1-2), pp.277-287
In seasonal species, photoperiod exerts tight regulation of reproduction to ensure that birth occurs at the most favorable time of yr. A distinct photoneuroendocrine circuit composed of the retina, suprachiasmatic nucleus (SCN) of the hypothalamus, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e528fe6ee7ddbcbd986ee42faabab94
https://hal.archives-ouvertes.fr/hal-00093404
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