Zobrazeno 1 - 10
of 1 097
pro vyhledávání: '"NEUROD1"'
Publikováno v:
JCRPE, Vol 16, Iss 2, Pp 218-223 (2024)
Maturity-onset diabetes of young ‘MODY’ type 6 is a rare form of monogenic diabetes caused by mutations in neuronal differentiation 1 (NEUROD1). Clinical features vary in a large spectrum in terms of age and body mass index (BMI) at diagnosis. He
Externí odkaz:
https://doaj.org/article/90c5e363a1264ecdb8c52ef8f3310a89
Autor:
Zongqin Xiang, Shu He, Rongjie Chen, Shanggong Liu, Minhui Liu, Liang Xu, Jiajun Zheng, Zhouquan Jiang, Long Ma, Ying Sun, Yongpeng Qin, Yi Chen, Wen Li, Xiangyu Wang, Gong Chen, Wenliang Lei
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 8, Pp 1781-1788 (2024)
Over the past decade, a growing number of studies have reported transcription factor-based in situ reprogramming that can directly convert endogenous glial cells into functional neurons as an alternative approach for neuroregeneration in the adult ma
Externí odkaz:
https://doaj.org/article/ab77e5342b5645589834b7c4b910ec6b
Autor:
Sehhoon Park, Tae Hee Hong, Soohyun Hwang, Simon Heeke, Carl M. Gay, Jiyeon Kim, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Hong Kwan Kim, Lauren Averett Byers, John V. Heymach, Yoon-La Choi, Se-Hoon Lee, Keunchil Park
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105062- (2024)
Summary: Background: Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohis
Externí odkaz:
https://doaj.org/article/40a1e82c84034502bbbe4835972d5109
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Subarachnoid hemorrhage (SAH) causes significant long-term neurocognitive dysfunction, which is associated with hippocampal neuroinflammation. Growing evidences have shown that astrocytes played a significant role in mediating neu
Externí odkaz:
https://doaj.org/article/0f11d397cadf4ff4a214d794bdb4cb6c
Autor:
ZHANG Juan, GE Xiaoxu, ZHANG Rong, JIANG Fusong, JIANG Yanyan, LI Ming, LI Tiantian, LIU Chanwei, CHEN Yating, LIU Limei
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 10, Pp 1255-1261 (2023)
Objective·To screen the mutations of NEUROD1 gene in families of maturity-onset diabetes of the young (MODY), and investigate the correlation between the mutation and MODY6 and its potential pathogenesis in Chinese.Methods·PCR-direct sequencing was
Externí odkaz:
https://doaj.org/article/69fed63d72b341369b4793afd8af0804
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8748 (2024)
Few effective treatments are available for small cell lung cancer (SCLC), indicating the need to explore new therapeutic options. Here, we focus on an antibody–drug conjugate (ADC) targeting the L1 cell adhesion molecule (L1CAM). Several publicly a
Externí odkaz:
https://doaj.org/article/8809ff101d28453b9214417a13d96d10
Publikováno v:
Cells, Vol 13, Iss 14, p 1223 (2024)
Neuronal reprogramming is a promising approach for making major advancement in regenerative medicine. Distinct from the approach of induced pluripotent stem cells, neuronal reprogramming converts non-neuronal cells to neurons without going through a
Externí odkaz:
https://doaj.org/article/364fcf833d5d46fa933f463b993844e7
Autor:
Xiaonan Kang, Dan Wang, Lu Zhang, Teng Huang, Siyue Liu, Xiaohui Feng, Yaoyao Guo, Ziyin Zhang, Zhongjing Wang, Huihui Ren, Gang Yuan
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-20 (2023)
Abstract Background Type 2 diabetes (T2D) is an independent risk factor for Alzheimer's disease (AD). Exendin-4 (Ex-4), a widely used glucagon-like peptide-1 receptor agonist drug in the treatment of T2D, has been demonstrated the therapeutic effects
Externí odkaz:
https://doaj.org/article/585e578ea60d43d7be435f35853b76f8
Autor:
Kengo Yasuda, Tomohiro Haruki, Tatsuya Miyamoto, Yuki Oshima, Shinji Matsui, Yasuaki Kubouchi, Hiroshige Nakamura
Publikováno v:
Thoracic Cancer, Vol 14, Iss 20, Pp 2001-2004 (2023)
Abstract Several transcription factors in small cell lung cancer (SCLC), including achaete‐scute homolog 1 (ASCL1) and neurogenic differentiation factor 1 (NEUROD1), contribute to rapid tumor growth and early metastatic dissemination. Recent studie
Externí odkaz:
https://doaj.org/article/9aa0d2f72c1942a1a7939e816b7d33a5
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