Zobrazeno 1 - 10
of 332
pro vyhledávání: '"NENAD BURSAC"'
Autor:
Alastair Khodabukus, Neel K. Prabhu, Taylor Roberts, Meghan Buldo, Amber Detwiler, Zachary D. Fralish, Megan E. Kondash, George A. Truskey, Timothy R. Koves, Nenad Bursac
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Dysferlin is a multi‐functional protein that regulates membrane resealing, calcium homeostasis, and lipid metabolism in skeletal muscle. Genetic loss of dysferlin results in limb girdle muscular dystrophy 2B/2R (LGMD2B/2R) and other dysfer
Externí odkaz:
https://doaj.org/article/6700577ad99f405e9fef15eac55bfc59
Autor:
David E. Lee, Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, James P. White
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Lee et al. demonstrate the protein Meteorin-like can rejuvenate the body’s immune system to enhance muscle regeneration in old age – in part by inducing the death of pro-fibrotic mesenchymal progenitor cells within the muscle.
Externí odkaz:
https://doaj.org/article/8fcfebcc8c834ce3ab90df115f69407e
Autor:
Qiao Zhang, Ren‐Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen, Barbara D. Lipes, Nenad Bursac, George A. Truskey
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/f2661d05231448598b09fc547fc38fbb
Autor:
Jacob C. Scherba, Marc K. Halushka, Nicholas D. Andersen, Joseph J. Maleszewski, Andrew P. Landstrom, Nenad Bursac, Carolyn Glass
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomere that causes otherwise unexplained cardiac hypertrophy and is associated with sudden death. While previous studies showed the role of the epigenetic modifier Brg1 in mous
Externí odkaz:
https://doaj.org/article/9ef311b9636c43918e8da9d9268310db
Autor:
Hung X. Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, Michael Pan, Andrew P. Landstrom, Craig Henriquez, Nenad Bursac
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f565703737de4d078598a60ba6a31e7c
Autor:
Hung X. Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, Michael Pan, Andrew P. Landstrom, Craig Henriquez, Nenad Bursac
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Therapies for cardiac arrhythmias could greatly benefit from approaches to enhance electrical excitability and action potential conduction in the heart by stably overexpressing mammalian voltage-gated sodium channels. However, the large size
Externí odkaz:
https://doaj.org/article/e4a62bc25c4744e394d6e8b834aeeb8e
Autor:
Christopher G Vann, Xin Zhang, Alastair Khodabukus, Melissa C. Orenduff, Yu-Hsiu Chen, David L. Corcoran, George A. Truskey, Nenad Bursac, Virginia B. Kraus
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Exercise affects the expression of microRNAs (miR/s) and muscle-derived extracellular vesicles (EVs). To evaluate sarcoplasmic and secreted miR expression in human skeletal muscle in response to exercise-mimetic contractile activity, we utilized a th
Externí odkaz:
https://doaj.org/article/01b3dc9dd88a468698e95c74c8051b9e
Autor:
Jason Wang, Chris J. Zhou, Alastair Khodabukus, Sabrina Tran, Sang-Oh Han, Aaron L. Carlson, Lauran Madden, Priya S. Kishnani, Dwight D. Koeberl, Nenad Bursac
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Wang et al. describe the development of a 3D in vitro model of human skeletal muscle that recapitulates the pathophysiology of Pompe disease. They further define a Pompe disease-specific transcriptional signature, confirm its presence in the Pompe my
Externí odkaz:
https://doaj.org/article/e7bed5b1c04b4acdbdebddf5309410f2
Autor:
Andrew M. Vekstein, David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen, Muath Bishawi, Garth W. Devlin, Aravind Asokan, Kenneth D. Poss, Dawn E. Bowles, Adam R. Williams, Nenad Bursac
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundThe optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is the gold standard, however, it is relatively invasive. We thus compared targ
Externí odkaz:
https://doaj.org/article/993f14381787463495862d3ca7622ee7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The neuromuscular junction (NMJ) is a specialized cholinergic synaptic interface between a motor neuron and a skeletal muscle fiber that translates presynaptic electrical impulses into motor function. NMJ formation and maintenance require tightly reg
Externí odkaz:
https://doaj.org/article/e4ac321d1ee3490eaacbf19a442604d1