Zobrazeno 1 - 10
of 23
pro vyhledávání: '"NEGATIVELY CHARGED ALBUMINS"'
Autor:
Vermeulen, Joost N., Dirk Meijer, Jan Over, Lange, Joep M. A., Johannes Proost, Bakker, Hester I., Leonie Beljaars, Wit, Ferdinand W. N. M., Prins, Jan M.
Publikováno v:
Antiviral therapy, 12(2), 273-278. International Medical Press Ltd
Antiviral therapy, 12(2), 273-278
University of Groningen
Antiviral therapy, 12(2), 273-278
University of Groningen
Background Succinylated human serum albumin (Suc-HAS) is a negatively charged neo-glycoprotein that binds to the positively charged V3–loop of HIV-1 gp120, acting as HIV-1-fusion inhibitor in vitro (IC50: 0.5–5.0 μg/ml). Suc-HSA was safe in rats
Publikováno v:
Antiviral therapy. 12(2):273-278
Background: Succinylated human serum albumin (Sue-HAS) is a negatively charged neo-glycoprotein that binds to the positively charged V3-loop of HIV-1 gp120, acting as HIV-1-fusion inhibitor in vitro (IC50: 0.5-5.0 mu g/ml). Sue-HSA was safe in rats a
Autor:
M.E. Kuipers, Catharina Reker-Smit, Leonie Beljaars, Peter Olinga, Piet Swart, Dirk K. F. Meijer, Geny M. M. Groothuis, Johannes H. Proost
Publikováno v:
European Journal of Pharmaceutical Sciences, 27(2-3), 123-132. ELSEVIER SCIENCE BV
Suc-HSA is a potent HIV-inhibitor with possible application in man. To facilitate the assessment of dosing regimens for future phase I clinical studies, we predicted the pharmacokinetic properties of Suc-HSA in man. Slices prepared from rat, monkey a
Autor:
Ben Berkhout, Jeroen L. B. van Wamel, Leonie Beljaars, Servaas Visser, René Floris, Dirk K. F. Meijer
Publikováno v:
Antiviral Research, 55(2):PII S0166-3542(02)00069-4, 341-355. ELSEVIER SCIENCE BV
Antiviral research, 55(2), 341-355. Elsevier
Antiviral research, 55(2), 341-355. Elsevier
In a search for natural proteins with anti-HIV activity, we screened a large set of purified proteins from bovine milk and peptide fragments thereof. Because several charged proteins and peptides are known to inhibit the process of virus entry, we se
Publikováno v:
Journal of Controlled Release. 46(1-2):139-156
The isolated perfused liver technique has been widely used in drug disposition studies. This versatile methodology in which many experimental conditions can be easily manipulated, allows one to investigate the various rate limiting steps in peptide t
Autor:
D.K F Meijer, P.J Swart
Publikováno v:
Journal of Controlled Release, 46(1-2), 139-156. Elsevier Bedrijfsinformatie b.v.
The isolated perfused liver technique has been widely used in drug disposition studies. This versatile methodology in which many experimental conditions can be easily manipulated, allows one to investigate the various rate limiting steps in peptide t
Publikováno v:
Journal of Drug Targeting, 9(2), 95-109. TAYLOR & FRANCIS LTD
The pharmacokinetics and metabolic fate of the intrinsically active (anti-HIV) drug carrier succinylated human serum albumin (Suc-HSA) was studied in rats. Suc-HSA was prepared by derivatizing HSA with 1,4-[C-14]-succinic anhydride, a modification by
The present study shows the lymphatic distribution of the negatively charged anti-HIV-l agents succinylated or aconytilated human serum albumins (HSAs) in rats. Quantitation of blood and lymphatic concentrations of these proteins was performed throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::e4b02d84fd15c55ae4ff5059ae538a0b
https://hdl.handle.net/11370/a4e1f153-089a-44e5-9f58-2bd68f02c5c9
https://hdl.handle.net/11370/a4e1f153-089a-44e5-9f58-2bd68f02c5c9
Publikováno v:
Biochemical Pharmacology, 58(9), 1425-1435. PERGAMON-ELSEVIER SCIENCE LTD
University of Groningen
University of Groningen
The present study shows the lymphatic distribution of the negatively charged anti-HIV-l agents succinylated or aconytilated human serum albumins (HSAs) in rats. Quantitation of blood and lymphatic concentrations of these proteins was performed throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::490ea62d2a5d17202fe041b564dd2a0d
https://research.rug.nl/en/publications/a4e1f153-089a-44e5-9f58-2bd68f02c5c9
https://research.rug.nl/en/publications/a4e1f153-089a-44e5-9f58-2bd68f02c5c9
Autor:
M.E. Kuipers, J.G Huisman, MP de Béthune, E. De Clercq, R Pauwels, Pieter Swart, Dkf Meijer, Hanneke Schuitemaker
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 11(5), 419-429
Journal of acquired immune deficiency syndromes and human retrovirology, 11(5), 419-429. Lippincott Williams and Wilkins
Journal of acquired immune deficiency syndromes and human retrovirology, 11(5), 419-429. Lippincott Williams and Wilkins
A novel class of polyanionic proteins with potent anti-human immunodeficiency virus type 1 activity, the negatively charged albumins (NCAs), have been reported previously. In vitro antiviral assays established that these compounds preferentially inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03698bd3b290fe230ae43ff3ae6e2c38
https://research.rug.nl/en/publications/94e9ee6c-8cbd-4606-b2fe-71c4cab47451
https://research.rug.nl/en/publications/94e9ee6c-8cbd-4606-b2fe-71c4cab47451