370. EXTERNAL VALIDATION OF A NOMOGRAM PREDICTING CONDITIONAL SURVIVAL AFTER CURATIVE TREATMENT OF ESOPHAGEAL CANCER

Autor: Nannet Schuring, NE Donlon, ERC Hagens, CMD Donohoe, MI van Berge Henegouwen, JV Reynolds, SS Gisbertz

Publikováno v: Diseases of the Esophagus. 35

To predict 5-year overall survival for esophageal cancer patients after neoadjuvant treatment followed by esophagectomy, recently a conditional survival nomogram was developed. This nomogram includes cN-stage, ypT-stage, ypN-stage, cardiac comorbidit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df44d543b05b49536cf810830a897a93
https://doi.org/10.1093/dote/doac051.370

P09.07 Novel insights into immune-independent functions of immune checkpoint inhibitors in oesophageal adenocarcinoma; potential implications for designing combination immuno-chemotherapy regimens to achieve synergistic responses

Autor: M Davern, C Buckley, C Fitzgerald, AB Heeran, NE Donlon, J McGrath, R O’ Brien, F O’ Connell, B Murphy, N Lynam-Lennon, JV Reynolds, SG Maher, AD Sheppard, A Bhardwaj, C Butler, N Ravi, J Lysaght

Publikováno v: Poster Presentations.

Background Immune checkpoint inhibitors (ICIs) reinvigorate anti-tumour immunity in oesophageal adenocarcinoma (OAC). However, emerging studies have identified novel immune-independent functions for immune checkpoints (ICs) in other solid tumour-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c35235016f5eb71009514b1273e5e858
https://doi.org/10.1136/jitc-2021-itoc8.57

Minimally invasive vs open vs hybrid esophagectomy for esophageal cancer: a systematic review and network meta-analysis.

Autor: Patton A; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Republic of Ireland., Davey MG; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Republic of Ireland., Quinn E; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Republic of Ireland., Reinhardt C; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Republic of Ireland., Robb WB; Department of Surgery, St. James's Hospital and Trinity College Dublin, Dublin, Republic of Ireland., Donlon NE; Department of Upper Gastrointestinal Surgery, Beaumont Hospital, Dublin, Republic of Ireland.

Publikováno v: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2024 Nov 28; Vol. 37 (12).

Complement is increased in treatment resistant rectal cancer and modulates radioresistance.

Autor: O'Brien RM; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: obrier30@tcd.ie., Meltzer S; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway. Electronic address: sebastian.meltzer@medisin.uio.no., Buckley CE; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: BUCKLECR@tcd.ie., Heeran AB; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: HEERANA@tcd.ie., Nugent TS; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: nugentti@tcd.ie., Donlon NE; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Department of Surgery, Beacon Hospital, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: DONLONN@tcd.ie., Reynolds JV; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: reynoljv@tcd.ie., Ree AH; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: a.h.ree@medisin.uio.no., Redalen KR; Department of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway. Electronic address: kathrine.redalen@ntnu.no., Hafeez A; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: adnan.hafeez@beaconhospital.ie., O'Ríordáin DS; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: diarmuid@dorconsultants.com., Hannon RA; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: robert.hannon@beaconhospital.ie., Neary P; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: Paulcneary@msn.com., Kalbassi R; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: kalbassir@yahoo.com., Mehigan BJ; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: BMehigan@stjames.ie., McCormick PH; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: PMcCormick@stjames.ie., Dunne C; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: caramdunne@gmail.com., Kelly ME; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: KELLYM11@tcd.ie., Larkin JO; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: larkin.dundalk@gmail.com., O'Sullivan J; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: osullij4@tcd.ie., Lysaght J; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: jlysaght@tcd.ie., Lynam-Lennon N; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: lynamlen@tcd.ie.

Publikováno v: Cancer letters [Cancer Lett] 2024 Nov 01; Vol. 604, pp. 217253. Date of Electronic Publication: 2024 Sep 14.

Optimal Treatment Strategies for cT2 Staged Adenocarcinoma of the Esophagus and the Gastroesophageal Junction: A Multinational, High-volume Center Retrospective Cohort Analysis.

Autor: Wirsik NM; Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany., Kooij CD; Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Dempster N; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Crnovrsanin N; Department of General, Visceral and Transplant Surgery, University Hospital of Heidelberg, Heidelberg, Germany., Donlon NE; Department of Surgery, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity St James' Cancer Institute, St James's Hospital, Dublin, Ireland., Uzun E; Department of General, Visceral and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Bhanot K; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Nienhüser H; Department of General, Visceral and Transplant Surgery, University Hospital of Heidelberg, Heidelberg, Germany., Polette D; Department of Upper Gastrointestinal Diseases, Karolinska University Hospital and Division of Surgery and Oncology, CLINTEC, Karolinska Institutet, Stockholm, Sweden., Kewani K; Department of Surgery, Amsterdam Umc Location University of Amsterdam, Amsterdam, The Netherlands., Grimminger P; Department of General, Visceral and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Reim D; Department of Surgery, School of Medicine and Health, Technical University of Munich, Munich, Germany., Seyfried F; Department of General, Visceral, Transplantation, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Bavaria, Germany., Fuchs HF; Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany., Gisbertz SS; Department of Surgery, Amsterdam Umc Location University of Amsterdam, Amsterdam, The Netherlands., Germer CT; Department of General, Visceral, Transplantation, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Bavaria, Germany., Ruurda JP; Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Klevebro F; Department of Upper Gastrointestinal Diseases, Karolinska University Hospital and Division of Surgery and Oncology, CLINTEC, Karolinska Institutet, Stockholm, Sweden., Schröder W; Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany., Nilsson M; Department of Upper Gastrointestinal Diseases, Karolinska University Hospital and Division of Surgery and Oncology, CLINTEC, Karolinska Institutet, Stockholm, Sweden., Reynolds JV; Department of Surgery, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity St James' Cancer Institute, St James's Hospital, Dublin, Ireland., Van Berge Henegouwen MI; Department of Surgery, Amsterdam Umc Location University of Amsterdam, Amsterdam, The Netherlands., Markar S; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Van Hillegersberg R; Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Schmidt T; Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany., Bruns CJ; Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany.

Publikováno v: Annals of surgery [Ann Surg] 2024 Nov 01; Vol. 280 (5), pp. 799-807. Date of Electronic Publication: 2024 Aug 07.