Zobrazeno 1 - 10
of 30
pro vyhledávání: '"NE, neutrophil elastase"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3060-3091 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air-blood barrier, leading to irreversible and substantial respiratory function damage. Patients with coronavirus disease 2019 (COVID-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7076f0b91326b1dc05f8b3eaf861f6
https://doi.org/10.1016/j.apsb.2021.04.023
https://doi.org/10.1016/j.apsb.2021.04.023
Autor:
N.V. Vorobjeva
Publikováno v:
Moscow University Biological Sciences Bulletin
— Neutrophils are the “first line” of defense against pathogens in the locus of inflammation, where they use effector functions such as phagocytosis, degranulation, and formation of reactive oxygen species (ROS). In 2004, Artuto Zychlinsky char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01f41f8c5f92ac886ffa0590ea714b0
http://europepmc.org/articles/PMC7869772
http://europepmc.org/articles/PMC7869772
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 321-333 (2021)
Drury, B, Hardisty, G, Gray, R D & Ho, G 2021, ' Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.03.002
Cellular and Molecular Gastroenterology and Hepatology
Drury, B, Hardisty, G, Gray, R D & Ho, G 2021, ' Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.03.002
Cellular and Molecular Gastroenterology and Hepatology
The Inflammatory Bowel Diseases (IBD), Ulcerative Colitis (UC) and Crohn’s Disease (CD) are characterised by chronic non-resolving gut mucosal inflammation involving innate and adaptive immune responses. Neutrophils, usually regarded as first respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152fa1aaf7135bb60518189272f1c4aa
http://www.sciencedirect.com/science/article/pii/S2352345X21000540
http://www.sciencedirect.com/science/article/pii/S2352345X21000540
Akademický článek
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Autor:
Richard D. Bland, Emilia M. Swietlik, Andrew J. Sweatt, Roham T. Zamanian, Mark R. Nicolls, Christopher J. Rhodes, Kazuya Miyagawa, Edda Spiekerkoetter, Shalina Taylor, Patricia A. del Rosario, Andrew Hsi, Stefan Gräf, Nicholas W. Morrell, Marlene Rabinovitch, Michal Bental-Roof, Francois Haddad, Martin R. Wilkins
Publikováno v:
Chest
Background Preclinical evidence implicates neutrophil elastase (NE) in pulmonary arterial hypertension (PAH) pathogenesis, and the NE inhibitor elafin is under early therapeutic investigation. Research Question Are circulating NE and elafin levels ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2effa4d59e57aa6956f99914ffc92b2
http://hdl.handle.net/10044/1/90261
http://hdl.handle.net/10044/1/90261
Autor:
Jane, Fisher, Tirthankar, Mohanty, Christofer A Q, Karlsson, S M Hossein, Khademi, Erik, Malmström, Attila, Frigyesi, Pontus, Nordenfelt, Johan, Malmstrom, Adam, Linder
Publikováno v:
Molecular & Cellular Proteomics : MCP
Severe coronavirus disease 2019 (COVID-19) can result in pneumonia and acute respiratory failure. Accumulation of mucus in the airways is a hallmark of the disease and can result in hypoxemia. Here, we show that quantitative proteome analysis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8396241ba8475c9e47aeeb3b287b70af
https://pubmed.ncbi.nlm.nih.gov/34139362
https://pubmed.ncbi.nlm.nih.gov/34139362
Publikováno v:
Redox Biology
Redox Biology, Vol 41, Iss, Pp 101946-(2021)
Redox Biology, Vol 41, Iss, Pp 101946-(2021)
Background Macrophage migration inhibitory factor (MIF) is an important immuno-regulatory cytokine and is elevated in inflammatory conditions. Neutrophils are the first immune cells to migrate to sites of infection and inflammation, where they genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea58a0bcf6db131c0df3a8cdd80fdd4
https://pubmed.ncbi.nlm.nih.gov/33823474
https://pubmed.ncbi.nlm.nih.gov/33823474
Autor:
Mizuko Osaka, Michiyo Deushi, Masayuki Yoshida, Jiro Aoyama, Akihito Ishigami, Tomoko Funakoshi
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Neutrophil adhesion to the vascular endothelium in the femoral artery of low-density lipoprotein receptor–null mice fed with HFD was significantly enhanced compared with wild-type mice fed with HFD or low-density
Highlights • Neutrophil adhesion to the vascular endothelium in the femoral artery of low-density lipoprotein receptor–null mice fed with HFD was significantly enhanced compared with wild-type mice fed with HFD or low-density
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04df94c59108ff2e67cbee057f800f21
https://pubmed.ncbi.nlm.nih.gov/34222722
https://pubmed.ncbi.nlm.nih.gov/34222722
Autor:
Mieke Metzemaekers, Susan M. Schlenner, Emanuela Pasciuto, Patrick Matthys, Stephanie Humblet-Baron, Elien Smeets, Adrian Liston, Axelle Kerstens, Joost Schymkowitz, Laura Seldeslachts, Paul Proost, Sarah Haßdenteufel, Carine Wouters, Frank Claessens, Julika Neumann, Teresa Prezzemolo, Nancy Boeckx, Vasiliki Lagou, John S. Barber, Frederic Rousseau, Bert Malengier-Devlies, Rob van der Kant, Erika Van Nieuwenhove, Christine Devalck, Isabelle Meyts, Sven Lang, Richard Zimmermann, Daniele Di Marino, Sebastian Munck, Mathijs Willemsen
Publikováno v:
Journal of allergy and clinical immunology
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Background: The molecular cause of severe congenital neutropenia (SCN) is unknown in 30% to 50% of patients. SEC61A1 encodes the α-subunit of the Sec61 complex, which governs endoplasmic reticulum protein transport and passive calcium leakage. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4167ed5c5db874f50ba44ce06bf3f6
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/307196
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/307196
Autor:
Lu, Ping-Hsun, Tseng, Chien-Wei, Lee, Jing-Ling, Lee, En-Yu, Lin, Yu-Ping, Lin, I-Hsin, Yu, Min-Chien, Lu, Kuo-Cheng, Kuo, Ko-Lin
Publikováno v:
Pharmacological Research-Modern Chinese Medicine
Background : SARS-CoV-2 has led to a sharp increase in the number of hospitalizations and deaths from pneumonia and multiorgan disease worldwide; therefore, SARS-CoV-2 has become a global health problem. Supportive therapies remain the mainstay treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2244e4d95e5172a8359236fa899ba577
https://doi.org/10.1016/j.prmcm.2021.100024
https://doi.org/10.1016/j.prmcm.2021.100024