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Akademický článek

Tunicamycin-Induced Endoplasmic Reticulum Stress Damages Complex I in Cardiac Mitochondria

Autor: Qun Chen, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky

Publikováno v: Life, Vol 12, Iss 8, p 1209 (2022)

Background: Induction of acute ER (endoplasmic reticulum) stress using thapsigargin contributes to complex I damage in mouse hearts. Thapsigargin impairs complex I by increasing mitochondrial calcium through inhibition of Ca2+-ATPase in the ER. Tunic

Externí odkaz: https://doaj.org/article/2d93a3f2648848d98954740243b8f8bb

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Mitochondrial DNA content and oxidation in bipolar disorder and its role across brain regions

Autor: B Navaid, Helena Kyunghee Kim, Ana Cristina Andreazza, D F Bodenstein, N C Brown, L T Young

Publikováno v: npj Schizophrenia, Vol 5, Iss 1, Pp 1-8 (2019)
NPJ Schizophrenia

The underlying pathology of bipolar disorder remains unknown, though evidence is accumulating to support a role of mitochondrial dysfunction. In this study, we aim to investigate electron transport chain complex I subunit NDUFS7 protein expression; m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9357089395db07565e18fe066fab90f6
http://link.springer.com/article/10.1038/s41537-019-0089-5

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Araucaria angustifolia (Bertol.) Kuntze has neuroprotective action through mitochondrial modulation in dopaminergic SH-SY5Y cells

Autor: Cátia dos Santos Branco, Ana Cristina Andreazza, Angela Duong, Abbie Wu, Gustavo Scola, Mirian Salvador, Alencar Kolinski Machado

Publikováno v: Molecular Biology Reports. 46:6013-6025

Brain disorders (BD) including neuropsychiatric and neurodegenerative diseases, are often associated with impairments in mitochondrial function and oxidative damage that can lead to neuronal injury. The mitochondrial complex I enzyme is one of the ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f865da605e23afd313bdc06e4f357d27
https://doi.org/10.1007/s11033-019-05037-6

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Modulation of Mitochondrial and Epigenetic Targets by Polyphenols-rich Extract from Araucaria angustifolia in Larynx Carcinoma

Autor: Gustavo Scola, Cátia dos Santos Branco, Angela Duong, Ana Cristina Andreazza, Mirian Salvador, Alencar Machado

Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 19:130-139

Background: Araucaria angustifolia extract (AAE) is a polyphenol-rich extract that has gained interest as a natural anticancer agent. Recent work suggests that AAE induces oxidative damage and apoptosis through its action on decreasing complex I acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3c586aa1752b7a572962d372b2d3ffb
https://doi.org/10.2174/1871520618666180816142821

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Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis

Autor: Xianrui Jiang, Honglei Wang, Wan-Yu Yan, Hao Meng, Jing Su, Liankun Sun, Xin Luo, Yao Jin

Publikováno v: Human cell. 35(1)

This study is to investigate the underlying mechanisms of mitochondrial quality control (MQC) regulated by HtrA2/Omi during ischemia/reperfusion (I/R). We utilized the mnd2 mouse model, which has a missense mutation in HtrA2/Omi, to investigate the H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2725c6f05e3fe8b41945d861164865be
https://pubmed.ncbi.nlm.nih.gov/34807408

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NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4(-/-) mice and Leigh syndrome patients: A stabilizing role for NDUFAF2

Autor: Leo G.J. Nijtmans, Mariël A.M. van den Brand, Jori A. L. Wagenaars, Leonid A. Sazanov, Werner J.H. Koopman, Jan A.M. Smeitink, Merel J. W. Adjobo-Hermans, Sjenet E. van Emst-de Vries, Mariusz R. Wieckowski, Richard J. Rodenburg, Peter H.G.M. Willems, Aleksandra Wojtala, Ria de Haas

Publikováno v: Biochimica et Biophysica Acta. Bioenergetics, 1861
Biochimica et Biophysica Acta. Bioenergetics, 1861, 8

Mutations in NDUFS4, which encodes an accessory subunit of mitochondrial oxidative phosphorylation (OXPHOS) complex I (CI), induce Leigh syndrome (LS). LS is a poorly understood pediatric disorder featuring brain-specific anomalies and early death. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbeb3235af78648702b370eecd47a8b4
https://hdl.handle.net/2066/220251

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Akademický článek

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Systematic expression analysis of the mitochondrial respiratory chain protein subunits identifies COX5B as a prognostic marker in clear cell renal cell carcinoma

Autor: Julia Tenbrock, Glen Kristiansen, Jörg Ellinger, Stefan C. Müller, Johannes Stein

Publikováno v: International journal of urology : official journal of the Japanese Urological AssociationReferences. 26(9)

OBJECTIVE To analyze the expression of mitochondrial respiratory chain protein subunits in clear cell renal cell carcinoma. METHODS Possible prognostic candidates were determined using The Cancer Genome Atlas database (n = 605). The database provided

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225fe623f9672c4d7e23a02894f0501b
https://pubmed.ncbi.nlm.nih.gov/31280487

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