Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn

Autor: David, Sychantha, Caitlyn M, Rotondo, Kamaleddin H M E, Tehrani, Nathaniel I, Martin, Gerard D, Wright

Publikováno v: The Journal of Biological Chemistry

Class B metallo-β-lactamases (MBLs) are Zn2+-dependent enzymes that catalyze the hydrolysis of β-lactam antibiotics to confer resistance in bacteria. Several problematic groups of MBLs belong to subclass B1, including the binuclear New Delhi MBL (N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bea992c73699acb7e93f3e53ad2e1b54
https://pubmed.ncbi.nlm.nih.gov/34181945

AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo- β -lactamases and indoleamine/tryptophan 2,3-dioxygenases.

Autor: Dai Q; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Yan Y; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Ning X; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Li G; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Yu J; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Deng J; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Yang L; College of Food and Bioengineering, Xihua University, Chengdu 610039, China., Li GB; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Jul; Vol. 11 (7), pp. 1931-1946. Date of Electronic Publication: 2021 Jan 26.