Zobrazeno 1 - 10
of 86
pro vyhledávání: '"NATSUKO CHIBA"'
Autor:
Tokiwa Motonari, Yuki Yoshino, Moe Haruta, Shino Endo, Shota Sasaki, Minoru Miyashita, Hiroshi Tada, Gou Watanabe, Toshiro Kaneko, Takanori Ishida, Natsuko Chiba
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Homologous recombination (HR) repairs DNA damage including DNA double-stranded breaks and alterations in HR-related genes results in HR deficiency. Germline alteration of HR-related genes, such as BRCA1 and BRCA2, causes hereditary breast an
Externí odkaz:
https://doaj.org/article/4e2508586b1c4525b4ec0ac5203eb4d5
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103008- (2024)
Summary: Aurora A is a critical kinase that functions in centrosome maturation and bipolar spindle assembly. On the other hand, Aurora A has E3 ubiquitin ligase activity and polyubiquitinates Breast cancer gene 1 (BRCA1)-interacting protein Obg-like
Externí odkaz:
https://doaj.org/article/3bf0b29dfa3b4b82822d5219e2b82189
Autor:
Yasushi Iida, Nozomu Yanaihara, Yuki Yoshino, Misato Saito, Ryosuke Saito, Junya Tabata, Ayako Kawabata, Masataka Takenaka, Natsuko Chiba, Aikou Okamoto
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
PARP inhibitors have changed the management of advanced high-grade epithelial ovarian cancer (EOC), especially homologous recombinant (HR)-deficient advanced high-grade EOC. However, the effect of PARP inhibitors on HR-proficient (HRP) EOC is limited
Externí odkaz:
https://doaj.org/article/9719d55dbd5e4a699da68eb2428ba9fb
Autor:
Zhenzhou Fang, Xingming Li, Yuki Yoshino, Moe Suzuki, Huicheng Qi, Hinari Murooka, Riko Katakai, Matsuyuki Shirota, Thi Anh Mai Pham, Ayako Matsuzawa, Kei Otsuka, Chikashi Ishioka, Takahiro Mori, Natsuko Chiba
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112850- (2023)
Summary: The BRCA1-interacting protein Obg-like ATPase 1 (OLA1) functions in centriole duplication. In this study, we show the role of the mitotic kinase Aurora A in the reduction of centrosomal OLA1. Aurora A binds to and polyubiquitinates OLA1, tar
Externí odkaz:
https://doaj.org/article/caf9765e3f364d1f80eb33fd713745a2
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205004 (2018)
Primordial germ cells (PGCs) are precursors of eggs and sperm. Although PGCs are unipotent cells in vivo, they are reprogrammed into pluripotent stem cells (PSCs), also known as embryonic germ cells (EGCs), in the presence of leukemia inhibitory fact
Externí odkaz:
https://doaj.org/article/40ee53baf11847f99de8604350893f97
Autor:
Masanobu Takahashi, Keigo Komine, Hiroo Imai, Yoshinari Okada, Ken Saijo, Masahiro Takahashi, Hidekazu Shirota, Hisatsugu Ohori, Shin Takahashi, Natsuko Chiba, Takahiro Mori, Hideki Shimodaira, Chikashi Ishioka
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176972 (2017)
Combination therapy with gemcitabine and docetaxel has been reported to be a good therapeutic strategy for patients with soft tissue sarcoma. The aim of the present study was to analyze the efficacy and toxicity of gemcitabine with docetaxel in Japan
Externí odkaz:
https://doaj.org/article/31cf3fe371fa49519cb7c4f6e3228b76
Autor:
Chung Yeng Looi, Miki Imanishi, Satoshi Takaki, Miki Sato, Natsuko Chiba, Yoji Sasahara, Shiroh Futaki, Shigeru Tsuchiya, Satoru Kumaki
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23640 (2011)
BACKGROUND:Lnk plays a non-redundant role by negatively regulating cytokine signaling of TPO, SCF or EPO. Retroviral expression of Lnk has been shown to suppress hematopoietic leukemic cell proliferation indicating its therapeutic value in cancer the
Externí odkaz:
https://doaj.org/article/2077ea894c674f629ee965977ad84d0f
Autor:
Shin Takahashi, Kota Ouchi, Yasuhiro Sakamoto, Takahiro Mori, Hideki Shimodaira, Masahiro Takahashi, Hisatsugu Ohori, Chieko Kudo, Yoshikazu Takahashi, Hiroo Imai, Shoko Akiyama, Masanobu Takahashi, Takeshi Suto, Yasuko Murakawa, Takayuki Oishi, Hideki Isobe, Yoshinari Okada, Sadayuki Kawai, Takashi Yoshioka, Toshihiko Sato, Yoshiaki Shindo, Shunsuke Sugiyama, Keigo Komine, Natsuko Chiba, Akira Okita, Takuhiro Yamaguchi, Chikashi Ishioka
Publikováno v:
Journal of Gastrointestinal Oncology. 14:676-691
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1c29cda8e66f571638cf39d71e016f8
https://doi.org/10.21037/jgo-22-862
https://doi.org/10.21037/jgo-22-862
Autor:
Tomoo Ikari, Yusuke Hiratsuka, Takayuki Oishi, Mitsunori Miyashita, Tatsuya Morita, Jennifer W Mack, Yoshinari Okada, Natsuko Chiba, Chikashi Ishioka, Akira Inoue
Purpose: Achieving “good death” is one of the important goals of palliative care. Providing goal-concordant care and an environment tailored to the patient's preferences can contribute to “good death.” However, the concordance rate between th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5d48a44d9558c0f508241b0cdd9225b
https://doi.org/10.21203/rs.3.rs-2980158/v1
https://doi.org/10.21203/rs.3.rs-2980158/v1
Autor:
Natsuko Chiba, Chikashi Ishioka, Toshio Watanabe, Honami Ogoh, Akihiro Kobayashi, Ayako Matsuzawa, Masahiro Nakayama, Kazuha Shindo, Yuhei Komiyama, Shun Abe, Matsuyuki Shirota, Hiroki Fujita, Huicheng Qi, Yuki Yoshino
BRCA1 functions as a tumor suppressor in DNA repair and centrosome regulation. Previously, Obg-like ATPase 1 (OLA1) was shown to interact with BARD1, a heterodimer partner of BRCA1. OLA1 binds to BRCA1, BARD1, and γ-tubulin and functions in centroso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::687e7b807d3b3501b3f8f241cb85eafa
https://doi.org/10.1158/1541-7786.c.6541221
https://doi.org/10.1158/1541-7786.c.6541221