Zobrazeno 1 - 10
of 25
pro vyhledávání: '"NATALIYA I. LENCHIK"'
Autor:
Lars Krogvold, Pia Leete, Ida M. Mynarek, Mark A. Russell, Ivan C. Gerling, Nataliya I. Lenchik, Clayton Mathews, Sarah J. Richardson, Noel G. Morgan, Knut Dahl-Jørgensen
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Aims/hypothesisThe Diabetes Virus Detection (DiViD) study has suggested the presence of low-grade enteroviral infection in pancreatic tissue collected from six of six live adult patients newly diagnosed with type 1 diabetes. The present study aimed t
Externí odkaz:
https://doaj.org/article/f02c08b77fd64629a1f94862a51ad465
Autor:
ALYSSA M. DYE, GRACE ASHBERY, NATALIYA I. LENCHIK, MARK A. ATKINSON, CLAYTON E. MATHEWS, MARTHA CAMPBELL-THOMPSON, IVAN C. GERLING
Publikováno v:
Diabetes. 71
Insulitis involves the infiltration of predominantly CD3+ T cells in islets in a patchy distribution between lobes in a pancreas. We hypothesized that gene expression profiling of insulin containing islets (INS+CD3-) vs. insulin containing insulitic
Autor:
Alessandro Iannaccone, Francesco Giorgianni, David D New, T J Hollingsworth, Allison Umfress, Albert H Alhatem, Indira Neeli, Nataliya I Lenchik, Barbara J Jennings, Jorge I Calzada, Suzanne Satterfield, Dennis Mathews, Rocio I Diaz, Tamara Harris, Karen C Johnson, Steve Charles, Stephen B Kritchevsky, Ivan C Gerling, Sarka Beranova-Giorgianni, Marko Z Radic, Health ABC study
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145323 (2015)
BACKGROUND:We investigated sera from elderly subjects with and without age-related macular degeneration (AMD) for presence of autoantibodies (AAbs) against human macular antigens and characterized their identity. METHODS:Sera were collected from part
Externí odkaz:
https://doaj.org/article/ab6a52129f954ae088d65b16655f0981
Autor:
Ivan C. Gerling, Sarah J. Richardson, Teresa Rodriguez-Calvo, Pouria Akhbari, Paola S. Apaolaza, Nataliya I. Lenchik, Jose Zapardiel-Gonzalo, Grace Nelson, Diana Balcacean
Publikováno v:
Science Advances
Sci. Adv. 7:eabd6527 (2021)
Sci. Adv. 7:eabd6527 (2021)
Interferon response sensors are expressed in the islet of Langerhans during the course of type 1 diabetes.
Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes (T1D), capable of inducing chronic inflammation
Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes (T1D), capable of inducing chronic inflammation
Autor:
Jian Wu, Dorothy N Kakoola, Nataliya I Lenchik, Dominic M Desiderio, Dana R Marshall, Ivan C Gerling
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46941 (2012)
Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse--a model for human type 1 diabetes (T1D). The molecular events that lead to insulitis and initiate autoimmune diabetes are poorly understood. Since T
Externí odkaz:
https://doaj.org/article/c99a76d233be497f9220e8ec5bae4970
Autor:
Alessandro Iannaccone, Ivan C. Gerling, TJ Hollingsworth, Diwa Koirala, Nataliya I. Lenchik, Francesco Giorgianni, David D New, Sarka Beranova-Giorgianni, Marko Z. Radic
Publikováno v:
Experimental Eye Research. 155:64-74
We report on a novel autoantigen expressed in human macular tissues, identified following an initial Western blot (WB)-based screening of sera from subjects with age-related macular degeneration (AMD) for circulating auto-antibodies (AAbs) recognizin
Autor:
Nataliya I. Lenchik, Clayton E. Mathews, Grace Nelson, Mark A. Atkinson, Martha Campbell-Thompson, Ivan C. Gerling
Publikováno v:
Diabetes. 68
Background: Type 1 diabetes (T1D) is an autoimmune condition long hypothesized to be enhanced or triggered by viral infections. Islet pathology in T1D is characterized by destruction and subsequent loss of insulin producing pancreatic beta cells. In
Autor:
Martha Campbell-Thompson, Elizabeth A. Butterworth, Nataliya I. Lenchik, Mark A. Atkinson, Clayton E. Mathews, Ivan C. Gerling
Publikováno v:
Diabetes. 67
The purpose of this study was to obtain comprehensive gene expression datasets from a large number of individual islets, with defined pathological phenotypes, from organ donors with different clinical stages of type 1 diabetes. Here we will present r
Publikováno v:
PROTEOMICS. 5:2202-2209
The use of "tri-reagents" allows the concomitant isolation of DNA, RNA, and proteins for a complete molecular characterization of biological samples. The aim of the current study was to perform the comparative evaluation of two-dimensional gel proteo
Publikováno v:
Annals of the New York Academy of Sciences. 1005:157-160
Transcriptome analysis is a powerful tool to characterize changes in leukocyte gene expression patterns and reveal very early molecular abnormalities in tissue. Herein, we report on characterization of the very earliest abnormalities in the transcrip