Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.

Autor: Elizabeth K Speliotes, Laura M Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J Kim, Cameron D Palmer, Vilmundur Gudnason, Gudny Eiriksdottir, Melissa E Garcia, Lenore J Launer, Michael A Nalls, Jeanne M Clark, Braxton D Mitchell, Alan R Shuldiner, Johannah L Butler, Marta Tomas, Udo Hoffmann, Shih-Jen Hwang, Joseph M Massaro, Christopher J O'Donnell, Dushyant V Sahani, Veikko Salomaa, Eric E Schadt, Stephen M Schwartz, David S Siscovick, NASH CRN, GIANT Consortium, MAGIC Investigators, Benjamin F Voight, J Jeffrey Carr, Mary F Feitosa, Tamara B Harris, Caroline S Fox, Albert V Smith, W H Linda Kao, Joel N Hirschhorn, Ingrid B Borecki, GOLD Consortium

Publikováno v: PLoS Genetics, Vol 7, Iss 3, p e1001324 (2011)

Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analys

Externí odkaz: https://doaj.org/article/c5813c26c983461e8c878bf0d8d9f7b5

The nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance

Autor: Ryan M. Gill, Daniela Allende, Patricia H. Belt, Cynthia A. Behling, Oscar W. Cummings, Cynthia D. Guy, Daniela Carpenter, Brent A. Neuschwander-Tetri, Arun J. Sanyal, James Tonascia, Mark L. Van Natta, Laura A. Wilson, Goro Yamada, Matthew Yeh, David E. Kleiner, for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)

Publikováno v: Hepatology Communications, Vol 7, Iss 2, Pp e0033-e0033 (2023)

Background and Aims:. The NAFLD activity score was developed to measure histologic changes in NAFLD during therapeutic trials. Hepatocyte ballooning (HB) is the most specific feature in steatohepatitis diagnosis, yet the impact of variations in HB ha

Externí odkaz: https://doaj.org/article/e064dc2fe4194521b39689b3632131c5

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Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis

Autor: Siddiqui, Mohammad Shadab, Van Natta, Mark L, Connelly, Margery A, Vuppalanchi, Raj, Neuschwander-Tetri, Brent A, Tonascia, James, Guy, Cynthia, Loomba, Rohit, Dasarathy, Srinivasan, Wattacheril, Julia, Chalasani, Naga, Sanyal, Arun J, NASH CRN

Publikováno v: Journal of hepatology, vol 72, iss 1

Background & aimsObeticholic acid (OCA), a farnesoid X receptor agonist, increases total and low-density lipoprotein cholesterol (LDL-C) in patients with non-alcoholic steatohepatitis. In the present study, we aimed to evaluate the impact of OCA ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::f66b0036e5292d7e56d1e8cc64e42a32
https://escholarship.org/uc/item/3t35g6bh

Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease

Autor: Bashir, Mustafa R, Wolfson, Tanya, Gamst, Anthony C, Fowler, Kathryn J, Ohliger, Michael, Shah, Shetal N, Alazraki, Adina, Trout, Andrew T, Behling, Cynthia, Allende, Daniela S, Loomba, Rohit, Sanyal, Arun, Schwimmer, Jeffrey, Lavine, Joel E, Shen, Wei, Tonascia, James, Van Natta, Mark L, Mamidipalli, Adrija, Hooker, Jonathan, Kowdley, Kris V, Middleton, Michael S, Sirlin, Claude B, NASH Clinical Research Network (NASH CRN)

Publikováno v: Bashir, Mustafa R; Wolfson, Tanya; Gamst, Anthony C; Fowler, Kathryn J; Ohliger, Michael; Shah, Shetal N; et al.(2018). Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease.. Journal of magnetic resonance imaging : JMRI. doi: 10.1002/jmri.26312. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0j98b870
Journal of magnetic resonance imaging : JMRI, vol 49, iss 5

BackgroundThe liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates.PurposeTo identify the most influential covariates for liver R2* values in patients with nonalcoho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::14c45f48617e7979a3caa950b00c3074
http://www.escholarship.org/uc/item/0j98b870