Zobrazeno 1 - 10
of 102
pro vyhledávání: '"NAPRT"'
Autor:
Zhu, Xiaotong 1, 11, Li, Ye 1, 11, Liu, Haixia 2, 3, 4, 11, Wang, Yuetong 5, Sun, Renhong 6, Jiang, Zhenzhou 1, Hou, Chun 1, Hou, Xianyu 5, Huang, Suming 7, Zhang, Huijuan 7, Wang, Haopeng 1, Jiang, Biao 8, Yang, Xiaobao 6, ∗, Xu, Bin 9, ∗∗, Fan, Gaofeng 1, 10, 12, ∗∗∗
Publikováno v:
In Cell Chemical Biology 20 June 2024 31(6):1203-1218
Autor:
Giorgia Colombo, Gian Paolo Caviglia, Alberto Ravera, Elisa Tribocco, Simone Frara, Chiara Rosso, Cristina Travelli, Armando A. Genazzani, Davide Giuseppe Ribaldone
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundNicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyl transferase (NAPRT) are key intracellular enzymes that participate in the biosynthesis on NAD but have also been shown to be released as proinflammatory cytoki
Externí odkaz:
https://doaj.org/article/78e54e08fd944b0cb5358eefb4c505d5
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Cancer cells are known to undergo metabolic adaptation to cater to their enhanced energy demand. Nicotinamide adenine dinucleotide (NAD) is an essential metabolite regulating many cellular processes within the cell. The enzymes required for NAD synth
Externí odkaz:
https://doaj.org/article/5cb7be2e57ba472c92601d9affa1268e
Autor:
Cecilia Baldassarri, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Stefano Fontana, Valerio Mammoli, Gabriele Minazzato, Elisa Marangoni, Massimiliano Gasparrini, Leonardo Sorci, Nadia Raffaelli, Loredana Cappellacci, Riccardo Petrelli, Fabio Del Bello
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 189 (2023)
The prevention of nicotinamide adenine dinucleotide (NAD) biosynthesis is considered an attractive therapeutic approach against cancer, considering that tumor cells are characterized by an increased need for NAD to fuel their reprogrammed metabolism.
Externí odkaz:
https://doaj.org/article/23800b1cafb64571a44463c8a8295339
Autor:
Cho-Hao Lin, Jimmy Chun-Tien Kuo, Ding Li, Aaron B. Koenig, Alexander Pan, Pearlly Yan, Xue-Feng Bai, Robert J. Lee, Kalpana Ghoshal
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes. Here, we dete
Externí odkaz:
https://doaj.org/article/a6dc99fa367445ea8a02da0162027b18
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Gabriele Minazzato, Elisa Marangoni, Carlo Fortunato, Riccardo Petrelli, Loredana Cappellacci, Fabio Del Bello, Leonardo Sorci, Massimiliano Gasparrini, Francesco Piacente, Santina Bruzzone, Nadia Raffaelli
Publikováno v:
Molecules, Vol 28, Iss 3, p 961 (2023)
The maintenance of a proper NAD+ pool is essential for cell survival, and tumor cells are particularly sensitive to changes in coenzyme levels. In this view, the inhibition of NAD+ biosynthesis is considered a promising therapeutic approach. Current
Externí odkaz:
https://doaj.org/article/f234e71ecbca48c09d5f4681ae107005
Autor:
Moustafa S. Ghanem, Irene Caffa, Alberto Del Rio, Jorge Franco, Marco Daniele Parenti, Fiammetta Monacelli, Michele Cea, Amr Khalifa, Aimable Nahimana, Michel A. Duchosal, Silvia Ravera, Nadia Bertola, Santina Bruzzone, Alessio Nencioni, Francesco Piacente
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 848 (2022)
Depriving cancer cells of sufficient NAD levels, mainly through interfering with their NAD-producing capacity, has been conceived as a promising anti-cancer strategy. Numerous inhibitors of the NAD-producing enzyme, nicotinamide phosphoribosyltransfe
Externí odkaz:
https://doaj.org/article/d530f82977654c3b99de8a51175fb322
Autor:
Jorge Franco, Francesco Piacente, Melanie Walter, Simone Fratta, Moustafa Ghanem, Andrea Benzi, Irene Caffa, Alexander V. Kurkin, Andrea Altieri, Patrick Herr, Macarena Martínez-Bailén, Inmaculada Robina, Santina Bruzzone, Alessio Nencioni, Alberto Del Rio
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 855 (2022)
NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein levels of NAPRT conferred resi
Externí odkaz:
https://doaj.org/article/3955bfbf6c32440698b24b3e27358897
Autor:
Xiao-qin Li, Jing Lei, Lin-hong Mao, Qing-liang Wang, Feng Xu, Tao Ran, Zhi-hang Zhou, Song He
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Nicotinamide adenine dinucleotide (NAD) is a profoundly important cofactor in redox reactions. Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are key enzymes for NAD salvage biosynthesis pathway, which
Externí odkaz:
https://doaj.org/article/4e8525939ac445d3be049a425c241fc5