Zobrazeno 1 - 10
of 31
pro vyhledávání: '"NAMPT, nicotinamide phosphoribosyltransferase"'
Autor:
Frederic A. Vallejo, Anthony Sanchez, Branko Cuglievan, Winston M. Walters, Guillermo De Angulo, Steven Vanni, Regina M. Graham
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
High-risk neuroblastoma (NB) portends very poor prognoses in children. Targeting tumor metabolism has emerged as a novel therapeutic strategy. High levels of nicotinamide-adenine-dinucleotide (NAD+) are required for rapid cell proliferation. Nicotina
Externí odkaz:
https://doaj.org/article/708da4feb36e4c00b359be5e663ee0ec
Akademický článek
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Autor:
Giorgia Colombo, Edoardo Luigi Maria Gelardi, Federica Carolina Balestrero, Marianna Moro, Cristina Travelli, Armando A. Genazzani
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide
Externí odkaz:
https://doaj.org/article/58d731c9ede84435a1cb782dd86f6700
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Federica Carolina Balestrero, Giorgia Colombo, Cristina Travelli, Armando A. Genazzani, Marianna Moro, Edoardo Luigi Maria Gelardi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa33b22ba4f6b25e32c39e4e76ff367d
https://www.frontiersin.org/articles/10.3389/fphar.2021.758320/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.758320/full
Autor:
Kirstein, A., Kehr, S., Nebe, M., Hanschkow, M., Barth, L., Lorenz, J., Penke, M., Breitfeld, J., Le Duc, D., https://orcid.org/0000-0001-7289-2552, Landgraf, K., Körner, A., Kovacs, P., Stadler, P., Kiess, W., Garten, A.
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates the insulin signaling pathway. Germline PTEN pathogenic variants cause PTEN hamartoma tumor syndrome (PHTS), associated with lipoma development in children. Adipose proge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ef7152ce7b26e3fa1186c680abb473b8
http://europepmc.org/articles/PMC8350019
http://europepmc.org/articles/PMC8350019
Autor:
Brandl, Lydia, Zhang, Yina, Kirstein, Nina, Sendelhofert, Andrea, Boos, Sophie Luise, Jung, Peter, Greten, Florian, Rad, Roland, Menssen, Antje
Publikováno v:
Neoplasia (New York, N.Y.)
We recently described a positive feedback loop connecting c-MYC, NAMPT, DBC1 and SIRT1 that contributes to unrestricted cancer cell proliferation. Here we determine the relevance of the loop for serrated route intestinal tumorigenesis using genetical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6fe6dfb6a26d9e9087f02fe28a19a298
http://europepmc.org/articles/PMC6710297
http://europepmc.org/articles/PMC6710297
Autor:
Sun Mi Hong, A-Yeon Lee, Sung-Min Hwang, Yu-Jin Ha, Moo-Jin Kim, Seongki Min, Won Hwang, Gyesoon Yoon, So Mee Kwon, Hyun Goo Woo, Hee-Hoon Kim, Won-Il Jeong, Han-Ming Shen, Sin-Hyeog Im, Dakeun Lee, You-Sun Kim
Publikováno v:
Redox Biology, Vol 50, Iss, Pp 102237-(2022)
Redox Biology
Redox Biology
Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage pathway and plays a crucial role in the maintenance of the NAD+ pool during inflammation. Considering that macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b37f0095181e8b947b12cb638325ce
https://doi.org/10.1016/j.redox.2022.102237
https://doi.org/10.1016/j.redox.2022.102237
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Morten, Dall, Anna S, Hassing, Lili, Niu, Thomas S, Nielsen, Lars R, Ingerslev, Karolina, Sulek, Samuel A J, Trammell, Matthew P, Gillum, Romain, Barrès, Steen, Larsen, Steen S, Poulsen, Matthias, Mann, Cathrine, Ørskov, Jonas T, Treebak
Publikováno v:
The Journal of Biological Chemistry
Nicotinamide phosphoribosyltransferase (NAMPT) converts nicotinamide to NAD+. As low hepatic NAD+ levels have been linked to the development of nonalcoholic fatty liver disease, we hypothesized that ablation of hepatic Nampt would affect susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65cfe1f1ba467bfc092fcef0e226a573
https://pubmed.ncbi.nlm.nih.gov/34762911
https://pubmed.ncbi.nlm.nih.gov/34762911