NADPH oxidase 5 is a novel susceptibility gene for type 2 diabetes mellitus.

Autor: Azarova I; Department of Biological Chemistry Kursk State Medical University Kursk Russian Federation Department of Biological Chemistry, Kursk State Medical University, Kursk, Russian Federation.; Laboratory of Biochemical Genetics and Metabolomics Research Institute for Genetic and Molecular Epidemiology Kursk State Medical University Kursk Russian Federation Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russian Federation., Klyosova E; Laboratory of Biochemical Genetics and Metabolomics Research Institute for Genetic and Molecular Epidemiology Kursk State Medical University Kursk Russian Federation Laboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russian Federation.; Department of Biology Medical Genetics and Ecology Kursk State Medical University Kursk Russian Federation Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation., Azarova V; Kursk Emergency Hospital Kursk Russian Federation Kursk Emergency Hospital, Kursk, Russian Federation., Polonikov A; Department of Biology Medical Genetics and Ecology Kursk State Medical University Kursk Russian Federation Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation.; Laboratory of Statistical Genetics and Bioinformatics Research Institute for Genetic and Molecular Epidemiology Kursk State Medical University Kursk Russian Federation Laboratory of Statistical Genetics and Bioinformatics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russian Federation.

Publikováno v: Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2024 Oct 17; Vol. 68, pp. e230527. Date of Electronic Publication: 2024 Oct 17 (Print Publication: 2024).

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NADPH Oxidase 5 (NOX5) Upregulates MMP-10 Production and Cell Migration in Human Endothelial Cells

Autor: Javier Marqués, Elena Ainzúa, Josune Orbe, María Martínez-Azcona, José Martínez-González, Guillermo Zalba

Publikováno v: Antioxidants, Vol 13, Iss 10, p 1199 (2024)

NADPH oxidases (NOXs) have been described as critical players in vascular remodeling, a mechanism modulated by matrix metalloproteinases. In this study, we describe for the first time the upregulation of MMP-10 through the activation of NOX5 in endot

Externí odkaz: https://doaj.org/article/d9a98367e9d64ef6a17d50a8ed97b6ea

Role of NOX1 and NOX5 in protein kinase C/reactive oxygen species‑mediated MMP‑9 activation and invasion in MCF‑7 breast cancer cells.

Autor: Song HK; Practical Research Division, Honam National Institute of Biological Resources, Mokpo, Jeollanam 58762, Republic of Korea., Kim JM; Department of Biochemistry, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea., Noh EM; Department of Oral Biochemistry, School of Dentistry, Wonkwang University, Iksan, Jeollabuk 54538, Republic of Korea., Youn HJ; Department of Surgery, Research Institute of Clinical Medicine, Jeonbuk National University Hospital, Jeonbuk National University and Biomedical Research Institute, Jeonju, Jeollabuk 54907, Republic of Korea., Lee YR; Department of Oral Biochemistry, School of Dentistry, Wonkwang University, Iksan, Jeollabuk 54538, Republic of Korea.

Publikováno v: Molecular medicine reports [Mol Med Rep] 2024 Oct; Vol. 30 (4). Date of Electronic Publication: 2024 Sep 02.

Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis.

Autor: Ho F; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Watson AMD; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.; Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, 75 commercial Road, Melbourne, VIC, 3004, Australia., Elbatreek MH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. melbatreek@ppmlab.net.; Department of Pharmacology and Personalised Medicine, MeHNS, Faculty of Health, Medicine & Life Science, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. melbatreek@ppmlab.net., Kleikers PWM; Department of Pharmacology and Personalised Medicine, MeHNS, Faculty of Health, Medicine & Life Science, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands., Khan W; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Sourris KC; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Dai A; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Jha J; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia., Schmidt HHHW; Department of Pharmacology and Personalised Medicine, MeHNS, Faculty of Health, Medicine & Life Science, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. hschmidt@ppmlab.net., Jandeleit-Dahm KAM; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia. karin.jandeleit-dahm@monash.edu.; Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany. karin.jandeleit-dahm@monash.edu.

Publikováno v: Scientific reports [Sci Rep] 2022 Jul 07; Vol. 12 (1), pp. 11570. Date of Electronic Publication: 2022 Jul 07.