Apollo-NADP ⁺ reveals in vivo adaptation of NADPH/NADP ⁺ metabolism in electrically activated pancreatic β cells.

Autor: Bui CV; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada., Boswell CW; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Ciruna B; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Rocheleau JV; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Science advances [Sci Adv] 2023 Oct 06; Vol. 9 (40), pp. eadi8317. Date of Electronic Publication: 2023 Oct 04.

Dissolved-oxygen feedback control fermentation for enhancing β-carotene in engineered Yarrowia lipolytica

Autor: Liang Liu, Shan Qiang, Yong Hong Meng, Ching Yuan Hu, Peng Jun Lv

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

The DO-stat fed-batch fermentation was carried out to explore the volumetric productivity of β-carotene in engineered Yarrowia lipolytica C11 strain. Using DO-stat fed-batch fermentation, we achieved 94 g/L biomass and 2.01 g/L β-carotene. Both bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769166496849aec52481f4c14be3b0d0
https://doi.org/10.1038/s41598-020-74074-0

Phase I pharmacological study of continuous chronomodulated capecitabine treatment

Autor: Alwin D. R. Huitema, Hilde Rosing, Niels de Vries, Jan H.M. Schellens, Dick Pluim, Bart A. W. Jacobs, Bastiaan Nuijen, Jeroen Roosendaal, Erik van Werkhoven, Serena Marchetti, Jos H. Beijnen

Publikováno v: Pharmaceutical Research
Pharmaceutical Research, 37(5). Springer New York LLC
Pharmaceutical research, 37(5):89. Springer New York

Purpose Capecitabine is an oral pre-pro-drug of the anti-cancer drug 5-fluorouracil (5-FU). The biological activity of the 5-FU degrading enzyme, dihydropyrimidine dehydrogenase (DPD), and the target enzyme thymidylate synthase (TS), are subject to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a72e841bba8beccd52150f77953495
https://dspace.library.uu.nl/handle/1874/410999

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure

Autor: Richard J. Rodenburg, Ger J.M. Stienen, Heder J de Vries, Hans W.M. Niessen, Liesbeth T. Wintjes, Rob C. I. Wüst

Publikováno v: Cardiovascular Research, 111(4), 362-372. Oxford University Press
Cardiovascular Research, 111, 4, pp. 362-72
Cardiovascular Research, 111(4), 362-72. Oxford University Press
Wüst, R C I, de Vries, H J, Wintjes, L T, Rodenburg, R J, Niessen, H W M & Stienen, G J M 2016, ' Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure ', Cardiovascular Research, vol. 111, no. 4, pp. 362-72 . https://doi.org/10.1093/cvr/cvw176
Cardiovascular Research, 111, 362-72
Wust, R C I, de Vries, H J, Wintjes, L T, Rodenburg, R J, Niessen, H W M & Stienen, G J M 2016, ' Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure ', Cardiovascular Research, vol. 111, no. 4, pp. 362-372 . https://doi.org/10.1093/cvr/cvw176

Item does not contain fulltext AIMS: In cardiac hypertrophy (CH) and heart failure (HF), alterations occur in mitochondrial enzyme content and activities but the origin and implications of these changes for mitochondrial function need to be resolved.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f83ac1f6055213ec68fe05b8298f2d
https://doi.org/10.1093/cvr/cvw176

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

Autor: Rongyuan Chen, Katrien De Bock, Federico Taverna, Elizabeth A. V. Jones, Massimiliano Mazzone, Lena-Christin Conradi, Jermaine Goveia, Rindert Missiaen, Bart Ghesquière, Peter Carmeliet, Anna Rita Cantelmo, Bernard Gallez, Bert Cruys, Mieke Dewerchin, Bernard Thienpont, Richard M Cubbon, Francisco Morales-Rodriguez, Sarah-Maria Fendt, Sandra Schoors, Ulrike Bruning, Annalisa Zecchin, Diether Lambrechts, Xavier Sagaert, Sebastian Jessberger, Xuri Li, Joanna Kalucka, Ulrike Harjes, Guy Eelen, Ilaria Elia, Kim Vriens, Gregor-Alexander Pilz, Nadine V. Conchinha, Aleksandra Brajic, Charlotte Dubois, Pauline de Zeeuw, Brian W. Wong, Samantha Scheinok, Laura Bierhansl, Lucas Treps

Publikováno v: Cell metabolism, Vol. 28, no. 6, p. 881-894.e13 (2018)
Cell Metabolism
Cell Metabolism, 28(6), 881-894.e13. Cell Press

Little is known about the metabolism of quiescent endothelial cells (QECs). Nonetheless, when dysfunctional, QECs contribute to multiple diseases. Previously, we demonstrated that proliferating endothelial cells (PECs) use fatty acid β-oxidation (FA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d56f53f8e852ef8e7f9fbf714d7b9a3
https://eprints.whiterose.ac.uk/135199/1/CELL-METABOLISM-FAO_quiescence_accepted.pdf