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Wortmannilactones I–L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilide hydroxamic acid to the culture medium of Talaromyces wortmannii

Autor: Yi-Yu Wang, Jun-Hui Liu, Xinhua Lu, Yuesheng Dong, Zhihui Zheng, Wen-Cai Liu, Ke Aibing, Zhilong Xiu, Yu-Shi Luan

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:5328-5333

With the aim of finding more potential inhibitors against NADH-fumarate reductase (specific target for treating helminthiasis and cancer) from natural resources, Talaromyces wortmannii was treated with the epigenome regulatory agent suberoylanilide h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f2d358cf52f866f43f8b97e1756585
https://doi.org/10.1016/j.bmcl.2016.09.032

Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria

Autor: Teruki Honma, Tsuyoshi Sasaki, Emmanuel Oluwadare Balogun, Dan Sato, Junko Ohmori, Madoka Nagahama, Masatsugu Oda, Shigeru Matsuoka, Tomoo Shiba, Kiyoshi Kita, Shigeharu Harada, Masayuki Inoue, Daniel Ken Inaoka

Publikováno v: International Journal of Molecular Sciences
Volume 16
Issue 7
Pages 15287-15308
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 15287-15308 (2015)

Recent studies on the respiratory chain of Ascaris suum showed that the mitochondrial NADH-fumarate reductase system composed of complex I, rhodoquinone and complex II plays an important role in the anaerobic energy metabolism of adult A. suum. The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cbd1c71bbd2278a2c320dea20a710a
https://doi.org/10.3390/ijms160715287

Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389

Autor: Kenichi Nonaka, Kiyoshi Kita, Kazuro Shiomi, Hideaki Ui, Hiroshi Tomoda, Satoshi Ōmura, Yong-Pil Kim, Kimitoshi Sakamoto, Rokuro Masuma, Mihoko Mori, Hiromi Morimoto

Publikováno v: Tetrahedron. 67:6582-6586

Screening for NADH-fumarate reductase inhibitors led to the isolation of the new polyketide compounds, ukulactones A and B (1 and 2, Fig. 1) from a culture broth of Penicillium sp. FKI-3389. The structure of ukulactone A was elucidated as a methylate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e56268a6fc1f1ff18393f83b367f813
https://doi.org/10.1016/j.tet.2011.05.090