Zobrazeno 1 - 10
of 39
pro vyhledávání: '"NA Dobbs"'
Autor:
Chris Twelves, C Cruickshanka, Michael Richards, NA Dobbs, Walter M Gregory, Robert D. Rubens
Publikováno v:
European Journal of Cancer. 39:580-586
This study aimed to develop an epirubicin dose modification scheme in women with breast cancer and liver dysfunction. We first identified target areas under the concentration-time curve (AUCs) of 2400 and 1600 ng/ml.h from pharmacokinetic studies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f64e3b9907afa3242cff6eeeea1b6e1d
https://doi.org/10.1016/s0959-8049(02)00669-x
https://doi.org/10.1016/s0959-8049(02)00669-x
Autor:
C. J. Twelves, Amanda-Jane Ramirez, Michael Richards, K E Towlson, MA Lawrence, Robert D. Rubens, M Summerhayes, NA Dobbs
Publikováno v:
British Journal of Cancer
Iododoxorubicin 80 mg m-2 i.v. was given 3 weekly for a maximum of six cycles as first-line chemotherapy to 14 evaluable women with metastatic breast cancer. The response rate was 14% (95% confidence intervals 4-40%); median time to progression was 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3931c526744bf97693b4f29f5d8ebfb7
https://doi.org/10.1038/bjc.1994.137
https://doi.org/10.1038/bjc.1994.137
Autor:
M A Richards, M.A. Smith, P E Graves, M. Lowry, C. J. Twelves, D.A. Porter, Robert D. Rubens, NA Dobbs
Publikováno v:
British Journal of Cancer
We have studied the metabolism of 31P-containing metabolites of post-menopausal breast cancers in vivo using magnetic resonance spectroscopy (MRS) and a 5.5 cm surface coil. Spectra were acquired from 23 diameter. The spectra of the 19 previously unt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdd9e2dc5b294d1cee794e095546b75
http://europepmc.org/articles/PMC1969456
http://europepmc.org/articles/PMC1969456
Autor:
Philip J. Johnson, Paulo Rizzi, Julie D. Warwick, C. J. Twelves, Elizabeth M. Metivier, Roger Williams, NA Dobbs
Publikováno v:
Cancer Chemotherapy and Pharmacology. 34:405-410
The pharmacokinetics and clinical activity of epirubicin were investigated in 16 patients with hepatocellular carcinoma (HCC) who received epirubicin at 75 mg/m2; the drug was given intravenously to 7 patients and via the hepatic artery to 9 patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7ba62fbdc5d6c70d82c5cca5cc9ecd
https://doi.org/10.1007/bf00685565
https://doi.org/10.1007/bf00685565
Autor:
Philip J. Johnson, R. Williams, NA Dobbs, Peter Harper, C. Kalayci, M. C. Aldous, EM Metivier
Publikováno v:
British Journal of Cancer
A standard dose of Adriamycin (60 mg m-2) was administered to 30 patients with inoperable hepatocellular carcinoma, 16 of whom were hyperbilirubinaemic (18-37 mumol l-1). The hyperbilirubinaemic patients experienced marked myelosuppression, but only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9e8604d3a09159b9182894c317d555
http://europepmc.org/articles/PMC1977380
http://europepmc.org/articles/PMC1977380
Publikováno v:
Cancer chemotherapy and pharmacology. 42(3)
We studied variability in doxorubicin pharmacokinetics in 24 patients with abnormal liver biochemistry tests. Blood samples were collected after the first cycle of single-agent doxorubicin given as an i.v. bolus and plasma levels were measured by hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba5ec06137acee7f56fccd6e42c3d61
https://pubmed.ncbi.nlm.nih.gov/9685058
https://pubmed.ncbi.nlm.nih.gov/9685058
Publikováno v:
Cancer chemotherapy and pharmacology. 36(6)
We studied the variability in doxorubicin pharmacokinetics in 27 patients, all of whom had normal liver biochemistry tests. Blood samples were collected after the first cycle of single-agent doxorubicin given as an i.v. bolus and plasma levels were m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c9a1243986cdf768ea026c982d4bb0
https://pubmed.ncbi.nlm.nih.gov/7554038
https://pubmed.ncbi.nlm.nih.gov/7554038
Autor:
Peter Canney, AL Stewart, Alison Curnow, NA Dobbs, Robert D. Rubens, C. J. Twelves, C.J. Tyrrell, Robert E. Coleman
Publikováno v:
British Journal of Cancer
Thirty-four evaluable patients were treated with vinorelbine, a novel, semisynthetic vinca alkaloid, as first-line chemotherapy for advanced breast cancer. They received vinorelbine 25 mg m-2 i.v. given weekly for a maximum of 16 cycles. Two patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df419eff0cdcc9c63d8761a3148786b2
https://pubmed.ncbi.nlm.nih.gov/7947109
https://pubmed.ncbi.nlm.nih.gov/7947109
Publikováno v:
The British journal of radiology. 67(793)
We have studied the metabolism of compounds containing 31P in normal breast using magnetic resonance spectroscopy (MRS). Spectra were acquired from non-lactating pre-menopausal breast (n = 14 women), lactating breast (n = 8) and post-menopausal breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6358487b7caf553e7f0be0f0fd95c192
https://pubmed.ncbi.nlm.nih.gov/8298873
https://pubmed.ncbi.nlm.nih.gov/8298873
Autor:
C. J. Twelves, NA Dobbs
Publikováno v:
Journal of chromatography. 572(1-2)
A sensitive and rapid method for measuring epidoxorubicin and its six metabolites by high-performance liquid chromatography using an advanced automated sample processor is described. Plasma samples (1 ml) were extracted using C2 cassettes, and revers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4378ce982abf8b6dde5d0ec2ba3dad7
https://pubmed.ncbi.nlm.nih.gov/1818055
https://pubmed.ncbi.nlm.nih.gov/1818055