Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse

Autor: Maja Malnar, Angela Bachi, Helena H. Chowdhury, Anemari Horvat, Patrizia D’Adamo, Antonia Gurgone, Saša Trkov Bobnar, Marko Muhič, Lorenzo Piemonti, Maria Lidia Mignogna, Michela Masetti, Jelena Velebit, Veronica Bianchi, Robert Zorec, Matjaž Stenovec, Alessia Mercalli, Katja Fink, Sara Belloli, Stefano Taverna, Maja Potokar, Marko Kreft, Rosa Maria Moresco, Nina Vardjan, Maddalena Ripamonti, Umberto Restuccia

Publikováno v: Metabolism
Metabolism, clinical and experimental
116 (2021): 154463. doi:10.1016/j.metabol.2020.154463
info:cnr-pdr/source/autori:D'Adamo P.; Horvat A.; Gurgone A.; Mignogna M.L.; Bianchi V.; Masetti M.; Ripamonti M.; Taverna S.; Velebit J.; Malnar M.; Muhic M.; Fink K.; Bachi A.; Restuccia U.; Belloli S.; Moresco R.M.; Mercalli A.; Piemonti L.; Potokar M.; Bobnar S.T.; Kreft M.; Chowdhury H.H.; Stenovec M.; Vardjan N.; Zorec R./titolo:Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse/doi:10.1016%2Fj.metabol.2020.154463/rivista:Metabolism, clinical and experimental (Print)/anno:2021/pagina_da:154463/pagina_a:/intervallo_pagine:154463/volume:116

Objectives GDI1 gene encodes for αGDI, a protein controlling the cycling of small GTPases, reputed to orchestrate vesicle trafficking. Mutations in human GDI1 are responsible for intellectual disability (ID). In mice with ablated Gdi1, a model of ID

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b634b090f73e01f5e64f5a419978ac
http://europepmc.org/articles/PMC7871014

Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways

Autor: Masayo Mori-Kojima, Chiaki Kawamoto, Satoshi Hara, Daniel Metzger, Katsuya Miyajima, Chiho Sumi-Ichinose, Tamae Ohye, Toshikuni Sasaoka, Hiroshi Ichinose, Nae Saito

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 296, pp.100544. ⟨10.1016/j.jbc.2021.100544⟩
The Journal of Biological Chemistry

Dopamine (DA) exerts well-known functions in the brain as a neurotransmitter. In addition, it plays important physiological roles in peripheral organs, but it is largely unknown how and where peripheral DA is synthesized and regulated. Catecholamines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc82740686aefef1da6e4fb1ac3ccb2
https://doi.org/10.1016/j.jbc.2021.100544

The antidepressant-like effects of

Autor: Saeid, Abbasi-Maleki, Zohre, Kadkhoda, Rahim, Taghizad-Farid

Publikováno v: Journal of Traditional and Complementary Medicine

Origanum majorana (L.) is an herb used in the treatment of diseases related to the nervous system in traditional medicine (e.g. as an anticonvulsant and sedative). The present study was conducted to investigate the antidepressant-like effects of Orig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bebcf0d1048bd128099774f11a7546a4
https://pubmed.ncbi.nlm.nih.gov/32695649

Contrasting changes in extracellular dopamine and glutamate along the rostrocaudal axis of the anterior cingulate cortex of the rat following an acute d-amphetamine or dopamine challenge

Autor: Elizabeth S. Ash, S. Clare Stanford, David J. Heal

Publikováno v: Neuropharmacology

There is evidence for functional specificity of subregions along the rostrocaudal axis of the anterior cingulate cortex (ACC). The subregion-specific distribution of dopaminergic afferents and glutamatergic efferents along the ACC make these obvious

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38078a7e86a04c56b077f2d6dcd8520
https://doi.org/10.1016/j.neuropharm.2014.04.003

Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection

Autor: J. Maehlen, Marianne Schultzberg, F Fonnum, Krister Kristensson, A.K. Mohammed, E. Norrby, O. Magnusson

Publikováno v: Neuroscience

Dysfunction of subcortical serotoninergic neurons has been implicated in some behaviour disturbances. The serotoninergic neurons in the dorsal and median raphe project widely in the brain. They innervate the olfactory bulbs and can be targets for exo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eec4fbfb933bff2b07edd17492fb829
http://europepmc.org/articles/PMC7131220