Zobrazeno 1 - 10
of 258
pro vyhledávání: '"N6-methyladenosine modification"'
Autor:
Ling Chen, Yanru Xiang, Shirong Zhong, Yinglin Wu, Jiaqi Liu, Yan Wu, Zhizhi Wang, Guodong Huang
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 10, Pp 1276-1283 (2024)
Objective(s): Ulcerative colitis (UC) is a commonly recurrent inflammatory bowel disease. T helper 17 (Th17)/regulatory T (Treg) cell balance plays an essential role in UC progression. However, it is unknown whether curcumin chitosan microspheres (CC
Externí odkaz:
https://doaj.org/article/076e5e8e91ee49c9a0e8b1ab32221275
Publikováno v:
Zhongguo cuzhong zazhi, Vol 19, Iss 6, Pp 655-663 (2024)
目的 本研究通过探讨N6-甲基腺苷（N6-methyladenosine，m6A）修饰及其调控蛋白在脑缺血小鼠中的表达变化，为脑缺血治疗的分子靶点研究提供参考。 方法 取60只雄性C57BL/6J小鼠，随机分为假手
Externí odkaz:
https://doaj.org/article/f3b40327afff4a61a1bf0c836cb72c32
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Background Acute kidney injury (AKI) is a frequent complication of severe acute pancreatitis (SAP). Previous investigations have revealed the involvement of FTO alpha-ketoglutarate-dependent dioxygenase (FTO) and aquaporin 3 (AQP3) in AKI. Therefore,
Externí odkaz:
https://doaj.org/article/164f10bde592449e824617ea3b8109d6
Autor:
Xiaohuang Lin, Jian Zhang, Zekai Wu, Yuan Shi, Mengting Chen, Maodong Li, Hong Hu, Kun Tian, Xiaoqi Lv, Chutao Li, Yang Liu, Xinyue Gao, Qiaomei Yang, Kunqi Chen, An Zhu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Mesaconitine (MA), a diester-diterpenoid alkaloid extracted from the medicinal herb Aconitum carmichaelii, is commonly used to treat various diseases. Previous studies have indicated the potent toxicity of aconitum despite its pharmacolog
Externí odkaz:
https://doaj.org/article/e64112f8d9d44a47aa52a3ec80da6ee4
Publikováno v:
Poultry Science, Vol 103, Iss 6, Pp 103671- (2024)
ABSTRACT: N6-methyladenosine (m6A) methylation in transcripts has been suggested to influence tumorigenesis in liver tumors caused by the avian leukosis virus subgroup J (ALV-J). However, m6A modifications during ALV-J infection in vitro remain uncle
Externí odkaz:
https://doaj.org/article/8aa8899b15b047d88fc666560ceff1e3
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background DNA N6-methyladenosine (6mA), as an important epigenetic modification, widely exists in bacterial genomes and participates in the regulation of toxicity, antibiotic resistance, and antioxidant. With the continuous development of s
Externí odkaz:
https://doaj.org/article/321b06223b7f48a899e0339ce6cc4861
Autor:
Min Yao, Zhirong Cheng, Xueyun Li, Yuexiang Li, Wei Ye, Hui Zhang, He Liu, Liang Zhang, Yingfeng Lei, Fanglin Zhang, Xin Lv
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract N6-methyladenosine (m6A) is present in diverse viral RNA and plays important regulatory roles in virus replication and host antiviral innate immunity. However, the role of m6A in regulating JEV replication has not been investigated. Here, we
Externí odkaz:
https://doaj.org/article/30658971105340f3a1f85a29c0613589
Autor:
Hanwen Li, Yingchuang Tang, Xingbang Ruan, Junxin Zhang, Hao Liu, Shiyu Yu, Hao Chen, Huilin Yang, Kai Zhang, Kangwu Chen
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)
Abstract Background Chordoma, a rare bone tumour with aggressive local invasion and high recurrence rate with limited understanding of its molecular mechanisms. Circular RNAs (circRNAs) have been extensively implicated in tumorigenesis, yet their inv
Externí odkaz:
https://doaj.org/article/ae76e26636a344e48a4bf3443e824811
Publikováno v:
环境与职业医学, Vol 40, Iss 9, Pp 1014-1023 (2023)
BackgroundOccupational and environmental particulate matter may cause fibrosis, accompanied by RNA m6A modification changes. Neodymium oxide (Nd2O3) can cause mouse lung fibrosis, which contains a large number of fibroblasts. ObjectiveTo investigate
Externí odkaz:
https://doaj.org/article/f3e70a1be0984fc99ebd7b78cfafa396
Autor:
Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan, Jie Zan
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Parkinson's disease (PD), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment. Dysregulation of N6
Externí odkaz:
https://doaj.org/article/7deaee7d7ea849f7a2e4446934a22c7b