Zobrazeno 1 - 10
of 7 403
pro vyhledávání: '"N6-methyladenosine"'
Publikováno v:
Zhongguo cuzhong zazhi, Vol 19, Iss 6, Pp 655-663 (2024)
目的 本研究通过探讨N6-甲基腺苷(N6-methyladenosine,m6A)修饰及其调控蛋白在脑缺血小鼠中的表达变化,为脑缺血治疗的分子靶点研究提供参考。 方法 取60只雄性C57BL/6J小鼠,随机分为假手
Externí odkaz:
https://doaj.org/article/f3b40327afff4a61a1bf0c836cb72c32
Autor:
Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, Nigel P. Mongan
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological m
Externí odkaz:
https://doaj.org/article/8fdaac6eb0dd41889920c42b595de135
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-21 (2024)
Abstract The resistance of cancer cells to treatment significantly impedes the success of therapy, leading to the recurrence of various types of cancers. Understanding the specific mechanisms of therapy resistance may offer novel approaches for allev
Externí odkaz:
https://doaj.org/article/6ebb5d0783234eec89c936b4f7ad4a5b
Autor:
Yanna Li, Zhixiong Wang, Peng Gao, Danping Cao, Runyu Dong, Menglin Zhu, Yao Fei, Xueliang Zuo, Juan Cai
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Circular RNAs (circRNAs) have been implicated in the development and progression of gastric cancer (GC). However, it remains unclear whether dysregulated circRNA affects immune escape and the efficacy of immunotherapy in GC. Our a
Externí odkaz:
https://doaj.org/article/6470854ab51b44819173fbd5386620ec
Autor:
Bo Wang, Yuting Wang, Wantong Wang, Zihao Wang, Yunzheng Zhang, Xin Pan, Xin Wen, Hongrui Leng, Jing Guo, Xiao-xin Ma
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Endometrial cancer (EC) stem cells (ECSCs) are pivotal in the oncogenesis, metastasis, immune escape, chemoresistance, and recurrence of EC. However, the specific mechanism of stem cell maintenance in EC cells (ECCs) has not been clarified.
Externí odkaz:
https://doaj.org/article/ada4e746ce00436dab28496f95e3c39d
Autor:
Fei Huang, Yuan Ren, Yufei Hua, Ying Wang, Ruomeng Li, Ning Ji, Xin Zeng, Ding Bai, Qianming Chen, Xikun Zhou, Junjie Wu, Jing Li
Publikováno v:
Molecular Biomedicine, Vol 5, Iss 1, Pp 1-17 (2024)
Abstract miRNA has emerged as a crucial regulator in various of pathological and physiological processes, yet its precise mechanism of action the detailed mechanism of their action in Head and neck squamous cell carcinoma (HNSCC) remains incompletely
Externí odkaz:
https://doaj.org/article/24b6f07fe4af404e876157a7a83ca5cd
Autor:
Bin Peng, Yinglin Lin, Gao Yi, Mingzhen Lin, Yao Xiao, Yezhenghong Qiu, Wenxia Yao, Xinke Zhou, Zhaoyu Liu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The epigenetic regulation of N6-methyladenosine (m6A) has attracted considerable interest in tumor research, but the potential roles of m6A regulator-related genes, remain largely unknown within the context of gastric cancer (GC) and tumor m
Externí odkaz:
https://doaj.org/article/3965a63e12bc4e6eb94a127f2baceff7
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Breast cancer (BC) is the most prevalent cancer in women globally. The tumor microenvironment (TME), comprising epithelial tumor cells and stromal elements, is vital for breast tumor development. N6-methyladenosine (m6A) modification plays a
Externí odkaz:
https://doaj.org/article/53d50cfccae74c51bb22b2bc656512a2
Autor:
Xiaolan Zhu, Wenxin Li, Minjun Lu, Junyu Shang, Jiamin Zhou, Li Lin, Yueqin Liu, Jie Xing, Mengxue Zhang, Shijie Zhao, Jingjing Lu, Xuyan Shi
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical and psychological health of patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H
Externí odkaz:
https://doaj.org/article/ad349b1aeaa4446d99e353c0019ecabe
Publikováno v:
Thoracic Cancer, Vol 15, Iss 18, Pp 1397-1409 (2024)
Abstract Background Alterations in epigenetic factors are recognized as key contributors to the emergence of human cancer. The active and reversible alteration of N6‐methyladenosine (m6A) RNA is crucial for controlling gene activity and determining
Externí odkaz:
https://doaj.org/article/16ad6bbea6bd4c9887b2d6b37925e235